Protein Alignment CG43163 and ttc28

DIOPT Version :10

• Sequence 1: NP_648228.2
• Gene: CG43163 / 38966
• FlyBaseID: FBgn0262719
• Length: 2523
• Species: Drosophila melanogaster
• Sequence 2: XP_073770432.1
• Gene: ttc28 / 100331958
• ZFINID: ZDB-GENE-140106-238
• Length: 2462
• Species: Danio rerio
• Alignment Length: 2536
• Identity: 1080/2536 - (42%)
• Similarity: 1488/2536 - (58%)
• Gaps: 316/2536 - (12%)

  Fly    56 ELPAANRALFLEKVRQSNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQ 120
            |.|..::|.|:|||||||.|||.|||.|||.||.:||:.||.|.|||||||||.||.||:..||.
Zfish    28 EGPGLSKAEFMEKVRQSNEACQLGDFQTAVKLYGEALRADPQNCILYSNRSAAHLKLGQYQTALD 92

  Fly   121 DATQARDLCPQWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGLVEASLKSPLRAA 185
            ||.:||.|.|:|||||||||||||.|||:.:|||||||||||:|.:.||:.|:|||::|||||.:
Zfish    93 DAVKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPLRES 157

  Fly   186 LEPTLQQLRTMQLQESPFVVSSVVGQELLQATQYSAAVTVLEAALRIGSCSLKLRGSVFSALSSA 250
            ||||.|||:.|:|.:|||||.||:|||||.|:.:.|:|.||||||:||:||||||||||||||||
Zfish   158 LEPTYQQLQKMKLDKSPFVVVSVIGQELLTASHHGASVVVLEAALKIGTCSLKLRGSVFSALSSA 222

  Fly   251 HWALNQLDQAIGYMQQDLAVAKSLGDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCK 315
            :|:|...:::..||||||.|||:|||..||||||||||||:||:|.::|||:.||:|||||||.|
Zfish   223 YWSLGNTEKSTAYMQQDLEVAKTLGDQTGECRAHGNLGSAFFSKGNYREALSNHRHQLVLAMKLK 287

  Fly   316 DTQAAAAALTSLGHVYTASGDYPNALASHKQCVQLFKQLGDRLQEAREIGNVGAVYLALGECEAA 380
            |.:||::||:||||||||.||||||||||||||.|.||..|:|.||||:||:||||:|:|:.:.|
Zfish   288 DREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDQLSEARELGNMGAVYIAMGDFDNA 352

  Fly   381 LDCHSQHLRLARKLHDQVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYA 445
            :.||.|||.:|:.|.::.||||||||||||:|.||.|.:|.:.|..||.:||.|.::|:|..|||
Zfish   353 VQCHEQHLSIAKSLGNKREEARAYSNLGSAYHYRRNFDKAMSYHTHVLELAQELEEKSIEMRAYA 417

  Fly   446 GLGHAARCAGDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGI 510
            ||||||||..|...:|::||:||::|...:|:..||||.|||||::||.|.::.|||||:|||.|
Zfish   418 GLGHAARCMQDLERAKQYHEQQLSIAEGLKDRAAEGRASSNLGIIHQMKGDYETALKLHKAHLSI 482

  Fly   511 ARSLGDRTGMGKAYGNMARMAHMAGSYEAAVKYHKQELAINQAMNDRSAEAATHGNLAVAYQALG 575
            |:.|.|....|:|||||....:..|:::.||:||:|||.|:..:|||:::|:|||||||||||||
Zfish   483 AQELNDYAAQGRAYGNMGNAYNALGAFDQAVRYHRQELQISMEVNDRASQASTHGNLAVAYQALG 547

  Fly   576 AHDAALTHYRAHLATARSLKDTAGEACALLNLGNCLSGRQEYEEAVPHYESYLMLAQELGDVAAE 640
            |||.||.||:.||..||.|:|...||.||.||||....|.|:.:|||:||.||.|:.:|.|:.:|
Zfish   548 AHDRALQHYQNHLNIARELRDIQSEARALGNLGNFHCSRGEFPQAVPYYEQYLRLSPDLQDMESE 612

  Fly   641 GKACHLLGYAHFSLGNYRAAVRYYDQDLALAKDAQHRPNMGRAYCNLGLAHLALGHTAAALECQQ 705
            ||.||.|||||:.|||::.||:||:||||||||...:.:..:||||||||..|||....|.|||:
Zfish   613 GKVCHNLGYAHYCLGNFQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALGDYTKAEECQK 677

  Fly   706 LFLAVAHATNQLPAKFRALGNIGDILIRTGSHEEAIKLYQRQLALARAAGDRSMEAAACGALGLA 770
            ..|::|.:.|...|:||||||:|||.:.......|:|.|::||:||....||.|||.|..|||.|
Zfish   678 YLLSLAQSLNNSQARFRALGNLGDIFLCKKDIPGAVKFYEQQLSLAHKVKDRKMEANAYAALGAA 742

  Fly   771 HRLMRRWDKALGHHTQELTLRQELGDLSGECRAHGHLGAVHMALCSWTNAVKCYQEQLERAQEQR 835
            :|:::::|||||:|||||.:.|||||:.|||:|||||.||:|:|..:|.|.|||:||||..|..:
Zfish   743 YRMLQKFDKALGYHTQELEVYQELGDIQGECQAHGHLAAVYMSLGKYTMAFKCYEEQLELGQRLK 807

  Fly   836 DAAVEAQAHGNLGIARLNMAHYEAAIGCLEAQLGTLERVSLPSTQADRARALGHLGDCYAALGDY 900
            |.:||||.:||:||.::||...|.|||..|.||..|:::|......||.||.|:|||||.:|||:
Zfish   808 DPSVEAQVYGNMGITKMNMGVMEEAIGYFEQQLAMLQQLSGNEAVLDRGRAYGNLGDCYDSLGDF 872

  Fly   901 EEALKCHDRQLQLALGLTSHRDQERAYRGLGQARRALGQLPAALVCLEKRLVVAHELHSPEIKAL 965
            |||:|.:|:.|.:|..|:..:|||:||||||...||:|.|..:|||.||||||||||.....||.
Zfish   873 EEAIKYYDQYLSVAQSLSHMQDQEKAYRGLGNGHRAMGNLQQSLVCFEKRLVVAHELGECGGKAQ 937

  Fly   966 AYGDLGHVHAALGNHAQALNCLEHQRELAQGLQDRALESDAMCALGQVQQRMGQHAQALELHRQD 1030
            |||:||.:|:.|||:.||::|||.|..:|:..|||.||.||.|.||.|.|.||:|..||:.|:.|
Zfish   938 AYGELGSLHSQLGNYEQAISCLERQLGIARDTQDRLLEGDASCGLGAVYQLMGEHDTALQFHQLD 1002

  Fly  1031 LEICTELSAPALQARALSNLGSVHESLGQQAEALKCYERQLEL---STDRLAKAMACLALGRVHH 1092
            |:|..|....:.|.||..|||..:||||....|:...|:.|.:   :.|.:||.:|..:|||.||
Zfish  1003 LQIAEETGNASCQGRAYGNLGLTYESLGNFERAVVYQEQHLSIAAQTNDLVAKTLAYSSLGRTHH 1067

  Fly  1093 QLEQHNQAVDYLRQGLASAQTTGKSEEEAKIRHQLGLALRSSGDAEGAHIQLETAAQLLESVRHE 1157
            .|:.::|:|.||::||..|:..|:.|:||||||:|||:|.:||:.|.:..||..|:.|.|::|||
Zfish  1068 ALQNYSQSVMYLQEGLRLAEQLGRREDEAKIRHRLGLSLWASGNLEESQHQLYRASALFETIRHE 1132

  Fly  1158 -QRSPETRQALYDLQTTCYQLLQVLLVALNRNEDALVAAERCKARGGADAV----SGEGSKVPL- 1216
             |.|.:.:.:|:||||:.||.||.:||:|..:::||..|||.:.|..||.:    :|:....|.
Zfish  1133 AQHSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYT 1197

  Fly  1217 -ADSESIQETVDRGRTTVLYYSLAGDQLFTWLLEPHVGIVRFHAAKIDAHSLQLPLSLSEEEEEE 1280
             ...|.|.:||:..|..|||:|||...|::|||.|..||::||...:...|.::..|
Zfish  1198 PVTVEHILDTVNGQRALVLYFSLAAGYLYSWLLAPGSGILKFHEVYLGEGSSEVGAS-------- 1254

  Fly  1281 EDLEMERELKLNRDQNQDQSEDQGTSNKANRLLERYMSLVRDNLGV---------NSQSLLHEGD 1336
                         |..:..:.....|:.....||::::..|:.|||         :|::....||
Zfish  1255 -------------DFQEGGACTPAASSCGGSSLEQHITNAREALGVDSYYSRACSSSETESEAGD 1306

  Fly  1337 GSGWRASTEQLLEDLPGAGGS--GGGGFLRMVSRNQLLNSSNYSLSSLFSVGSVGGSVASLQGST 1399
                  ..:|..|:|.....|  ...|||||||||.|.|.|..|::||||     .:|:.::..|
Zfish  1307 ------LLDQQFEELNNKLNSVTDPTGFLRMVSRNNLFNRSCQSMTSLFS-----NTVSPVKEGT 1360

  Fly  1400 RSVGSRSSRRAPGLPVWRGPSCLHILYNLLLAPFDDLLPAGEADTNRQGRRELVLVLDSSLYLVP 1464
            .|:..|:|..:      :.|  |..||:||:||.:..|........|  .|:|||||:..|||:|
Zfish  1361 SSLPRRTSALS------KPP--LRALYDLLIAPMEGGLMHSSGPVGR--HRQLVLVLEGELYLIP 1415

  Fly  1465 FAILRAAQEDGEYLCERCAILTAPSLQSMRSRPRIRRDRARP-------PKALVVGGPRIPSNLA 1522
            ||:|:.:..: |||.||.:::..||:.|:.:..::...|..|       ..|.|||.||:|.::.
Zfish  1416 FALLKGSSSN-EYLYERFSLIAVPSIGSLGTTAKVHPRRTGPLLCNGGSSMAAVVGNPRLPPSVM 1479

  Fly  1523 ELWGWAGAESPAALQEAAMVADMLQATALAGSNATKESVLAELPSAECVHFAANISWQLGAVVLS 1587
            :.|.|  ...|.|.:||.||||:|....|||..||||.|::.|..|||.|||.:|||:|.|:||:
Zfish  1480 DRWLW--GPMPTAEEEAHMVADLLGCQPLAGPAATKERVMSALTQAECAHFATHISWKLAALVLT 1542

  Fly  1588 P------GDVVTAE-----------------QQEQKEPHE----------PQMTDFTLAAGELRQ 1619
            |      |....|.                 .:..:.|.:          |.:.:|.|.|.::..
Zfish  1543 PSQDSNSGSGAAASGGGAGGGESGGKSNYTIPESLRVPDDASDAESICDSPPLQEFLLTAADILD 1607

  Fly  1620 LRLSARLVVLSSY-HSVEPITGDGVAQLAGGWLLAGAGVVLISLWPVPETAAKILLRAFYSALLQ 1683
            |||..:||||.|| .|...:|.|||..|...:|.|||..||:||||||..|:|:.:.|||||||.
Zfish  1608 LRLPTKLVVLGSYQESDSKVTADGVVGLTRAFLAAGAQCVLVSLWPVPVAASKMFVHAFYSALLN 1672

  Fly  1684 GARAARALAEAMQTVQHTKHFAHPANWAGFLLVGSNIRLSNKVAM-GHALCELLRTPERCRDALR 1747
            |.:|:.|||:||:|||.:|.|:||:|||||:|:||:::|::..:: |.||.|:|:.||:.|||||
Zfish  1673 GTKASAALADAMKTVQSSKQFSHPSNWAGFMLIGSDVKLNSPSSLIGQALAEILQHPEKARDALR 1737

  Fly  1748 VCLHLVEKSLQRIHRGQKNAMYTTQQSIENKAGPVAGWKDLLMAVGFRVEPAANGIPASVFFPQA 1812
            |.|||||||||||..||:|:|||:|||:|||.|.|.||:.||.|||||::.|..|:||:||||..
Zfish  1738 VLLHLVEKSLQRIQNGQRNSMYTSQQSVENKVGGVPGWQALLTAVGFRLDSAGTGLPAAVFFPTT 1802

  Fly  1813 DPEERLAQCSASLQALLALTPATLQALGKLVHVNSAEYAGD---------IIAVVRNILAQFPGS 1868
            ||.:||.|||.:||:||.|.|..||||.||:   :|...|:         ::.::..:|.|..
Zfish  1803 DPGDRLQQCSTTLQSLLGLPPPALQALCKLI---TASETGEQLINRAVKNVVGMLHQVLVQLQ-- 1862

  Fly  1869 NPATGSSSTKSD-AIAETCFIEMPLSVRLWRVAGCHELLASVGFDLTEVGADQVILRTGKQANRR 1932
                 |...:.| ::|.   |::.:||:|||:.||||.||::||||.|||.::|:|:||||||||
Zfish  1863 -----SGEKEHDFSLAP---IQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVVLKTGKQANRR 1919

  Fly  1933 QCQFVLQALLALFDTREAPKNLGLDRDSDHSSSCESLAEPEMDVASIPPAASSTPSVNGGNKAPL 1997
            ...|.||:||||||:.|.||.|.|    |.|||.||||..:.....:|.          |...|
Zfish  1920 TMHFALQSLLALFDSTELPKRLSL----DSSSSLESLASAQSVCHQLPM----------GYPNP- 1969

  Fly  1998 PLHPRSAFISYVRRRGEPDGGRTDAIGGVGSGALDSSLANTTDSEHSLSDGYVTQPGFGLSNPRL 2062
            |..|..           ||...:|||......::.||::
Zfish  1970 PFSPPC-----------PDSLASDAISVYSLSSIASSMS-------------------------- 1997

  Fly  2063 GYASMRAPVRVSRPGGGGESDAAFTPSPPVTDPSLSLALAHQTRIRSLYSQTSSAAIVPPVATTL 2127
                     .:|||.|..|                  .::.::|.:.|......|.:......|:
Zfish  1998 ---------FLSRPEGASE------------------FISQRSRQQELERHRGGAGLFASHRHTV 2035

  Fly  2128 NRRPDSS--SSASSTTDWEGSGHATVLRRGVSTAIPQQQPPLPPPRPPTFHNLSVGAGGRSKPKI 2190
            ..|..||  .:.....|.|..|::.:    .|..:..|...|  |||....|....|.|
Zfish  2036 VPRSRSSPHGAVGGHEDEEYEGYSII----SSEPLGSQCDTL--PRPANHRNHRGAARG------ 2088

  Fly  2191 KLGSAQSSLAARVNKEHALFMDRLSVRTELSAPGSGNAMTSGSAARKPLALPEEEDVSNVVFNPS 2255
                                             |:|.......::|..::.|.....:.:|.:|:
Zfish  2089 ---------------------------------GAGRGYAVSVSSRGSVSTPTSPVKATLVPSPN 2120

  Fly  2256 SLYFSQTDSDLLNEPKQEETPPPTKSSTKSLQDSMMRHMNRELTPSISEMYHDRNVGLGLAPPLS 2320
            |.:      ..:.:....:|....:|||::  ||.:: ...|.||.              ||
Zfish  2121 SPF------QKVGKVSSSDTGESDQSSTET--DSTVK-SQEERTPG--------------AP--- 2159

  Fly  2321 KLLLSPNYEEQEVVSITEACPQSGANLKTLVDAVSELELSGSSSGATMPTVVGGGA---NEVEGT 2382
               |.|....|:::..|:      ::::.:......:.|....||...||..||.|   :|....
Zfish  2160 ---LDPQELAQKILEETQ------SHMRAVETLQRSVPLGDGMSGGGPPTPTGGSAFRSSETSAF 2215

  Fly  2383 SGTSAEATCPICGEPADVICRCKAVTIQKKSILKPWLSNVP---DSSLVQASELTTADILERRLE 2444
            |..|:.|:......|.....:..:.|...:.:...:  |.|   ::||.:.|:.:.......:.:
Zfish  2216 SRPSSRASIKAQSSPLPARPKPPSRTSSLQKVSSGY--NSPATSETSLKEGSQPSPTSDSHAQFK 2278

  Fly  2445 IHTATSSELRSGAPYSVDLSRRDEGDGRSVADSQCSSNYKRVLASASGGALSLAGIG--KGSEAE 2507
            :...:|       |||..:|       ||.::...||.::....||...|||.:..|  :.|.|:
Zfish  2279 LKYPSS-------PYSGHIS-------RSPSNISPSSGHQSPAGSAPSPALSYSSTGSTRSSPAD 2329

  Fly  2508 A 2508
            |
Zfish  2330 A 2330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_648228.2	PEP_TPR_lipo	<78..751	CDD:274350	406/672 (60%)
		TPR repeat	98..128	CDD:276809	20/29 (69%)
		TPR repeat	133..161	CDD:276809	23/27 (85%)
		TPR repeat	243..269	CDD:276809	15/25 (60%)
		TPR repeat	281..311	CDD:276809	21/29 (72%)
		TPR repeat	321..349	CDD:276809	23/27 (85%)
		TPR repeat	354..390	CDD:276809	20/35 (57%)
		TPR repeat	401..429	CDD:276809	17/27 (63%)
		TPR repeat	441..469	CDD:276809	16/27 (59%)
		TPR repeat	482..509	CDD:276809	17/26 (65%)
		TPR repeat	522..549	CDD:276809	12/26 (46%)
		TPR	523..781	CDD:440225	137/257 (53%)
		TPR repeat	561..595	CDD:276809	25/33 (76%)
		TPR repeat	600..630	CDD:276809	17/29 (59%)
		TPR repeat	642..669	CDD:276809	17/26 (65%)
		TPR repeat	680..716	CDD:276809	17/35 (49%)
		TPR repeat	721..749	CDD:276809	13/27 (48%)
		TPR_12	801..865	CDD:315987	35/63 (56%)
		TPR repeat	801..829	CDD:276809	17/27 (63%)
		Spy	841..>1073	CDD:443119	117/231 (51%)
		TPR repeat	841..878	CDD:276809	17/36 (47%)
		TPR repeat	883..913	CDD:276809	18/29 (62%)
		TPR repeat	924..949	CDD:276809	14/24 (58%)
		TPR repeat	964..998	CDD:276809	17/33 (52%)
		COG4995	975..1718	CDD:444019	305/804 (38%)
		TPR repeat	1004..1032	CDD:276809	14/27 (52%)
		TPR repeat	1043..1073	CDD:276809	13/29 (45%)
		TPR repeat	1081..1109	CDD:276809	12/27 (44%)
		CHAT	1421..1718	CDD:432771	136/337 (40%)
ttc28	XP_073770432.1	None