DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unr and CSDE1

DIOPT Version :9

Sequence 1:	NP_001137912.1	Gene:	Unr / 38963	FlyBaseID:	FBgn0263352	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	NP_001229820.1	Gene:	CSDE1 / 7812	HGNCID:	29905	Length:	844	Species:	Homo sapiens

Alignment Length:	944	Identity:	380/944 - (40%)
Similarity:	522/944 - (55%)	Gaps:	175/944 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PPQIGVFQSNSVLTNGAGSGSSIFGSQSSNSSAAAADP---------------SQTTRETGIIEK 193
            ||.:.:..|:|..::|..........|.|.|    .||               |...||||:|||
Human    18 PPSLSLPLSSSSTSSGTKKQKRTPTYQRSMS----FDPNLLHNNGHNGYPNGTSAALRETGVIEK 78

  Fly   194 LLHSYGFIQCCERQARLFFHFSQFSGNIDHLKIGDPVEFEMTYDRRTGKPIASQVSKIAPEVVLS 258
            ||.|||||||.|||||||||.||::||:..||:||.||||::.|||||||||.::.||..| :|.
Human    79 LLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLVKIKQE-ILP 142

  Fly   259 EERVTGTVTTEL--RTDSANNVLNSSETTGRISYENRGECFFLPYTKDDVEGNVNLRAGDKVSFQ 321
            |||:.|.|...:  ..:|.:........||.:.||..||.|:|.||.:||||||.|..|||::|.
Human   143 EERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFV 207

  Fly   322 IATNQR-GNLGACHIRLENPAQPVKYRGVVCSMKESFGFIERADVVKEIFFHFSEAEGNVE-LRP 384
            |..|:. |.:.|.:|.|....| .:.:||||:|||:||||||.|||||||||:||.:|::| |:|
Human   208 IDNNKHTGAVSARNIMLLKKKQ-ARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQP 271

  Fly   385 GDDVEFTIQTRSVSGSGDPTNPNMLQSKMQSASVPPQGREFACNITRLAPGSVIFEDVDSTVYKG 449
            ||||||||:.|:                         |:|.|.::..|..|:|||||:....::|
Human   272 GDDVEFTIKDRN-------------------------GKEVATDVRLLPQGTVIFEDISIEHFEG 311

  Fly   450 QVLKSLDRNNPVRQNNDPLPGRIRYRALDY-SEVEVPFGDKDQKGDFTLRHGDWVQFLLATDRRD 513
            .|.|.:.: .|.:..||||||||:   :|: ...|:||||||.|...||..||.|:|.::|||||
Human   312 TVTKVIPK-VPSKNQNDPLPGRIK---VDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRD 372

  Fly   514 QLQRATSIALLDETFKVSGEKREQGTIASLKEGFGFLRCVERQARLFFHFTEVLDTSREIDINDE 578
            :|:|||:|.:|..||:.:.|.||.|.||::::||||::||:|..|:||||:|:|| ..::.|.||
Human   373 KLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILD-GNQLHIADE 436

  Fly   579 VEFTVIQEPGLAYNNSRLQAIRIKHLPPNSVQFETLVASNIEGCVTREA----PK--SPIKSQDR 637
            |||||:.:...|..|   .|||||.||..:|.|.:.......|.|.:||    ||  ||.|.:::
Human   437 VEFTVVPDMLSAQRN---HAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEK 498

  Fly   638 -VEGGVITYEHADVKKTIMYFLKDCE--KPPRIGERVRFDIYMVKRNKECIAVNVQQVSLHQQQQ 699
             .|.|:|.|:...||.||.:..||.|  ..|:||::|.|.|                    ..:|
Human   499 EAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSI--------------------SDKQ 543

  Fly   700 QQQQQLHLNQSNAGANINQNDQLGGLSNGISSSSSNASLQNGYVMHGSPGGSTSSVGSNNPVHLD 764
            :..||:.......|.|.|....|
Human   544 RPGQQVATCVRLLGRNSNSKRLL------------------------------------------ 566

  Fly   765 EFKMENNNHAGSDAGQVYRGFIAVMKENFGFIETLSHDEEVFFHFSNYMGNPNWLELGQEVEYTL 829
                               |::|.:|:|||||||.:||:|:|||:|.:.|:.:.||||..|||:|
Human   567 -------------------GYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSL 612

  Fly   830 ARNGNTSVSGNCLPAENVRMLPK-NSIPQPAVLETTHNGVVARPLRCINPDQQEYAGLIEILDE- 892
            ::.     .||.:.||.|..... |.|.:.|. .|.::|.|.||||.::|.|.||.|:|||::|
Human   613 SKG-----KGNKVSAEKVNKTHSVNGITEEAD-PTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEG 671

  Fly   893 -LRTTVISQHEFGITSLVNKRDLLQKGDLVSFRIDESGRAACVNA--VRQKKRATVDSIKGQFGF 954
             ::..|   :.|||..:.||.|.||||:.|.|::...|:.|...|  :...:||||:.:|.||||
Human   672 DMKGEV---YPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGF 733

  Fly   955 LNFEVEDGKKLFFHMSEVQGNTVALHPGDTVEFSVVTNQRNGKSSACNVLKIND--------RPD 1011
            :|:||.|.||||||:.||| :.:.|..||.|||||:.|||.||.|||||.::.:        |||
Human   734 INYEVGDSKKLFFHVKEVQ-DGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPD 797

  Fly  1012 RLISRLK-LNGDD-TVPRLILIRAPKGPQGK-GF 1042
            ||::||| :..|| :.|||:::|.|:||... ||
Human   798 RLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGF 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unr	NP_001137912.1	CSP	188..251	CDD:214633	44/62 (71%)
		S1_like	347..395	CDD:299122	36/48 (75%)
		CSP	537..604	CDD:214633	33/66 (50%)
		S1_like	790..834	CDD:299122	24/43 (56%)
		CSP	942..1006	CDD:214633	40/63 (63%)
CSDE1	NP_001229820.1	CSD	72..136	CDD:278729	45/63 (71%)
		3_prime_RNase	231..>404	CDD:273033	93/201 (46%)
		CSD	232..294	CDD:278729	40/86 (47%)
		CSP	396..459	CDD:214633	33/66 (50%)
		CSD	567..628	CDD:278729	31/65 (48%)
		CSD	720..784	CDD:278729	40/64 (63%)
		SUZ-C	818..834	CDD:372374	6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148396
Domainoid	1	1.000	97	1.000	Domainoid score	I7285
eggNOG	1	0.900	-	-		E1_28K4H
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5179
Inparanoid	1	1.050	612	1.000	Inparanoid score	I918
Isobase	1	0.950	-	0	Normalized mean entropy	S7206
OMA	1	1.010	-	-		QHG47946
OrthoDB	1	1.010	-	-		D136290at2759
OrthoFinder	1	1.000	-	-		FOG0008060
OrthoInspector	1	1.000	-	-		oto91349
orthoMCL	1	0.900	-	-		OOG6_105871
Panther	1	1.100	-	-	LDO	PTHR12913
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4970
SonicParanoid	1	1.000	-	-		X6011
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	17	16.790