DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unr and csde1

DIOPT Version :9

Sequence 1:	NP_001137912.1	Gene:	Unr / 38963	FlyBaseID:	FBgn0263352	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_021333866.1	Gene:	csde1 / 336679	ZFINID:	ZDB-GENE-030131-8623	Length:	884	Species:	Danio rerio

Alignment Length:	946	Identity:	380/946 - (40%)
Similarity:	529/946 - (55%)	Gaps:	185/946 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 SSNSSAAAADPSQTTRETGIIEKLLHSYGFIQCCERQARLFFHFSQFSGNIDHLKIGDPVEFEMT 235
            ::..|..|...|...||||::||||.|||||||.|||||||||.||::||:..|||||.||||::
Zfish    58 NNGHSGFANGTSMGIRETGVVEKLLTSYGFIQCSERQARLFFHCSQYNGNLQELKIGDDVEFEVS 122

  Fly   236 YDRRTGKPIASQVSKIAPEVVLSEERVTGTVTTELRTDSANNVLN-------------------- 280
            .|||||||||.::.||..| :|.|||::|.|..:|.. |...||:
Zfish   123 SDRRTGKPIAVKLVKIKAE-MLPEERISGQVGPDLHA-SPLTVLHGFIHPVVSAIPSHLDGKSAP 185

  Fly   281 SSETTGRISYENRGECFFLPYTKDDVEGNVNLRAGDKVSFQIATNQR-GNLGACHIRLENPAQPV 344
            ....||.:.||..||.|:|.||.:||||||:|..||||||.:.||:. |.:.|.:|.|....:.
Zfish   186 GQLPTGSVCYERNGEVFYLTYTLEDVEGNVSLDIGDKVSFYMETNKHTGAVSAHNIVLVQKKES- 249

  Fly   345 KYRGVVCSMKESFGFIERADVVKEIFFHFSEAEGNVE-LRPGDDVEFTIQTRSVSGSGDPTNPNM 408
            :.:||||:.||:||||||.|||||||||:||.:|::| |:.||||||||:.|:
Zfish   250 RCQGVVCATKEAFGFIERGDVVKEIFFHYSEFKGDLEALQAGDDVEFTIKERN------------ 302

  Fly   409 LQSKMQSASVPPQGREFACNITRLAPGSVIFEDVDSTVYKGQVLKSLDRNNPVRQNNDPLPGRIR 473
                         |:|.|.::..|..|:|||||:....::|.|.|.:.: .|.:..||||||||.
Zfish   303 -------------GKEVATDVRLLPQGTVIFEDISIETFEGTVSKVIPK-VPTKNQNDPLPGRIS 353

  Fly   474 YRALDYSEVEVPFGDKDQKGDFTLRHGDWVQFLLATDRRDQLQRATSIALLDETFKVSGEKREQG 538
            .| :::::.|:.||:||.|...||..||.|||.::|||||:|:|||:|.:|.:||..:.|.||.|
Zfish   354 AR-INFTDKELLFGEKDTKSKVTLLEGDHVQFNISTDRRDKLERATNIDILPDTFHFTKETREMG 417

  Fly   539 TIASLKEGFGFLRCVERQARLFFHFTEVLDTSREIDINDEVEFTVI---QEPGLAYNN----SRL 596
            .||::::||||::||:|.||:||||:|||:.| ::.|:|||||||:   ..|...:.:    .|.
Zfish   418 VIAAMRDGFGFIKCVDRDARMFFHFSEVLEES-QLHISDEVEFTVVPLFNRPSCLHQDMLSAQRN 481

  Fly   597 QAIRIKHLPPNSVQFETLVASNIEGCVTREA-------PKSPIKSQDR----------VEGGVIT 644
            .|:|||.||..:|.|.|.......|.|.:||       ..||.|.:::          .|.|:|.
Zfish   482 HAVRIKKLPKGTVSFHTQSELRFMGVVEKEAIPAITIKNSSPSKGKEKKKDKGKVEKDAEEGLIA 546

  Fly   645 YEHADVKKTIMYFLKDCEKP--PRIGERVRFDIYMVKRNKECIAVNVQQVSLHQQQQQQQQQLHL 707
            ||...||.|:.|.:||.|..  |::|::|.|.|..|||..:..||:.:               .|
Zfish   547 YEDVGVKTTLPYHIKDLEGGVYPQLGDKVEFSISEVKRTGQQSAVSFK---------------IL 596

  Fly   708 NQSNAGANINQNDQLGGLSNGISSSSSNASLQNGYVMHGSPGGSTSSVGSNNPVHLDEFKMENNN 772
            |:                                            :|||...:
Zfish   597 NR--------------------------------------------AVGSKRLL----------- 606

  Fly   773 HAGSDAGQVYRGFIAVMKENFGFIETLSHDEEVFFHFSNYMGNPNWLELGQEVEYTLARNGNTSV 837
                       |:||.:|:|||||||.:||:|:|||:|...|:.:..:||..|||||::.
Zfish   607 -----------GYIATLKDNFGFIETANHDQEIFFHYSEVCGDVDSFDLGDTVEYTLSKG----- 655

  Fly   838 SGNCLPAENV-RMLPKNSIPQPAVLETTHNGVVARPLRCINPDQQEYAGLIEILDELRTTVISQH 901
            .||.:.||.| ::...|.:.:. |..|...|.|.||||.::|.|.||.|||||.:: .:.....:
Zfish   656 KGNKISAEKVTKIAAVNGVGED-VSTTVSLGKVVRPLRSVDPSQTEYQGLIEITED-GSNKGQSY 718

  Fly   902 EFGITSLVNKRDLLQKGDLVSFR---IDESGRAACVNAVRQKKRATVDSIKGQFGFLNFEVEDGK 963
            .|||..:.||.|.||||:||.|:   :.::|:....|.:.| :||.|:.:|.||||:.:||.:.|
Zfish   719 PFGIVGMANKGDCLQKGELVKFQLCTVAQTGQKMACNIMPQ-RRALVECVKDQFGFITYEVGESK 782

  Fly   964 KLFFHMSEVQGNTVALHPGDTVEFSVVTNQRNGKSSACNVLKIND--------RPDRLISRLK-L 1019
            |||||:.||| :::.|..||.|||||:.|||.||.|||||.::::        |||||::||| :
Zfish   783 KLFFHVKEVQ-DSLELQAGDEVEFSVILNQRTGKCSACNVRRVSEGPKPVATPRPDRLVNRLKSI 846

  Fly  1020 NGDDT-VPRLILIRAPKGP-QGKGFSVLARHPRIPG 1053
            ..||: .|||::||.|:|| ..||||| .|..|.||
Zfish   847 TLDDSNAPRLVIIRQPRGPDNSKGFSV-ERKSRQPG 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unr	NP_001137912.1	CSP	188..251	CDD:214633	44/62 (71%)
		S1_like	347..395	CDD:299122	34/48 (71%)
		CSP	537..604	CDD:214633	34/73 (47%)
		S1_like	790..834	CDD:299122	23/43 (53%)
		CSP	942..1006	CDD:214633	37/63 (59%)
csde1	XP_021333866.1	CSD	74..138	CDD:278729	45/63 (71%)
		CSD	251..313	CDD:278729	38/86 (44%)
		CSP	416..489	CDD:214633	34/73 (47%)
		CSP	607..668	CDD:214633	31/65 (48%)
		S1_like	760..824	CDD:324540	37/64 (58%)
		SUZ-C	858..872	CDD:315560	7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582280
Domainoid	1	1.000	97	1.000	Domainoid score	I7216
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5179
Inparanoid	1	1.050	617	1.000	Inparanoid score	I865
OMA	1	1.010	-	-		QHG47946
OrthoDB	1	1.010	-	-		D136290at2759
OrthoFinder	1	1.000	-	-		FOG0008060
OrthoInspector	1	1.000	-	-		oto40044
orthoMCL	1	0.900	-	-		OOG6_105871
Panther	1	1.100	-	-	LDO	PTHR12913
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4970
SonicParanoid	1	1.000	-	-		X6011
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940