DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unr and Csde1

DIOPT Version :9

Sequence 1:	NP_001137912.1	Gene:	Unr / 38963	FlyBaseID:	FBgn0263352	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_038957515.1	Gene:	Csde1 / 117180	RGDID:	619726	Length:	844	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	379/923 - (41%)
Similarity:	518/923 - (56%)	Gaps:	170/923 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 FQSNSVLTNGAGSGSSIFGSQSSNSSAAAADPSQTTRETGIIEKLLHSYGFIQCCERQARLFFHF 214
            |..|.:..||...        ..|.::||      .||||:|||||.|||||||.|||||||||.
  Rat    49 FDPNLLHNNGHNG--------YPNGTSAA------LRETGVIEKLLTSYGFIQCSERQARLFFHC 99

  Fly   215 SQFSGNIDHLKIGDPVEFEMTYDRRTGKPIASQVSKIAPEVVLSEERVTGTVTTEL--RTDSANN 277
            ||::||:..||:||.||||::.|||||||||.::.||.|| :..|||:.|.|...:  ..:|.:.
  Rat   100 SQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAIKLVKIKPE-IHPEERMNGQVVCAVPHNLESKSP 163

  Fly   278 VLNSSETTGRISYENRGECFFLPYTKDDVEGNVNLRAGDKVSFQIATNQR-GNLGACHIRLENPA 341
            .......||.:.||..||.|:|.||.:||||||.|..|||::|.|..|:. |.:.|.:|.|....
  Rat   164 AAPGQSPTGSVCYERNGEVFYLTYTSEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKK 228

  Fly   342 QPVKYRGVVCSMKESFGFIERADVVKEIFFHFSEAEGNVE-LRPGDDVEFTIQTRSVSGSGDPTN 405
            | .:|:||||:|||:||||||.|||||||||:||.:|::| |:|||||||||:.|:
  Rat   229 Q-ARYQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRN--------- 283

  Fly   406 PNMLQSKMQSASVPPQGREFACNITRLAPGSVIFEDVDSTVYKGQVLKSLDRNNPVRQNNDPLPG 470
                            |:|.|.::..|..|:|||||:....::|.|.|.:.: .|.:..||||||
  Rat   284 ----------------GKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPK-VPSKNQNDPLPG 331

  Fly   471 RIRYRALDY-SEVEVPFGDKDQKGDFTLRHGDWVQFLLATDRRDQLQRATSIALLDETFKVSGEK 534
            ||:   :|: ...|:||||||.|...||..||.|:|.::|||||:|:|||:|.:|..||:.:.|.
  Rat   332 RIK---VDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEA 393

  Fly   535 REQGTIASLKEGFGFLRCVERQARLFFHFTEVLDTSREIDINDEVEFTVIQEPGLAYNNSRLQAI 599
            ||.|.||::::||||::||:|.||:||||:|:|| ..::.|.|||||||:.:...|..|   .||
  Rat   394 REMGVIAAMRDGFGFIKCVDRDARMFFHFSEILD-GNQLHIADEVEFTVVPDMLSAQRN---HAI 454

  Fly   600 RIKHLPPNSVQFETLVASNIEGCVTREA----PK--SPIKSQDR-VEGGVITYEHADVKKTIMYF 657
            |||.||..:|.|.:.......|.|.:||    ||  ||.|.:|: .|.|:|.|:...||.||.:.
  Rat   455 RIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKDKEAEDGIIAYDDCGVKLTIAFQ 519

  Fly   658 LKDCE--KPPRIGERVRFDIYMVKRNKECIAVNVQQVSLHQQQQQQQQQLHLNQSNAGANINQND 720
            .||.|  ..|:||::|.|.|                    ..:|:..||:.......|.|.|...
  Rat   520 AKDVEGSTSPQIGDKVEFSI--------------------SDKQRPGQQIATCVRLLGRNSNSKR 564

  Fly   721 QLGGLSNGISSSSSNASLQNGYVMHGSPGGSTSSVGSNNPVHLDEFKMENNNHAGSDAGQVYRGF 785
            .|                                                             |:
  Rat   565 LL-------------------------------------------------------------GY 568

  Fly   786 IAVMKENFGFIETLSHDEEVFFHFSNYMGNPNWLELGQEVEYTLARNGNTSVSGNCLPAENVRML 850
            :|.:|:|||||||.:||:|:|||:|.:.|:.:.||||..|||:|::.     .||.:.||.|...
  Rat   569 VATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG-----KGNKVSAEKVNKT 628

  Fly   851 PK-NSIPQPAVLETTHNGVVARPLRCINPDQQEYAGLIEILDE--LRTTVISQHEFGITSLVNKR 912
            .. |.|.:.| ..|.::|.|.||||.::|.|.||.|:|||::|  ::..|   :.|||..:.||.
  Rat   629 HSVNGITEEA-NPTIYSGKVIRPLRGVDPTQIEYQGMIEIVEEGDMKGEV---YPFGIVGMANKG 689

  Fly   913 DLLQKGDLVSFRIDESGRAACVNA--VRQKKRATVDSIKGQFGFLNFEVEDGKKLFFHMSEVQGN 975
            |.||||:.|.|::...|:.|...|  :...:||||:.:|.||||:|:||.|.||||||:.||| :
  Rat   690 DCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQ-D 753

  Fly   976 TVALHPGDTVEFSVVTNQRNGKSSACNVLKIND--------RPDRLISRLK-LNGDD-TVPRLIL 1030
            .:.|..||.|||||:.|||.||.|||||.::.:        |||||::||| :..|| :.|||::
  Rat   754 GIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMV 818

  Fly  1031 IRAPKGPQGK-GF 1042
            :|.|:||... ||
  Rat   819 LRQPRGPDNSMGF 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unr	NP_001137912.1	CSP	188..251	CDD:214633	44/62 (71%)
		S1_like	347..395	CDD:299122	36/48 (75%)
		CSP	537..604	CDD:214633	34/66 (52%)
		S1_like	790..834	CDD:299122	24/43 (56%)
		CSP	942..1006	CDD:214633	40/63 (63%)
Csde1	XP_038957515.1	CSD	72..136	CDD:278729	45/63 (71%)
		CSD	233..294	CDD:278729	40/85 (47%)
		CSP	396..459	CDD:214633	34/66 (52%)
		CSD	567..628	CDD:278729	31/65 (48%)
		CSD	720..784	CDD:278729	40/64 (63%)
		SUZ-C	802..834	CDD:403952	14/30 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342306
Domainoid	1	1.000	97	1.000	Domainoid score	I7088
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5179
Inparanoid	1	1.050	618	1.000	Inparanoid score	I853
OMA	1	1.010	-	-		QHG47946
OrthoDB	1	1.010	-	-		D136290at2759
OrthoFinder	1	1.000	-	-		FOG0008060
OrthoInspector	1	1.000	-	-		oto98431
orthoMCL	1	0.900	-	-		OOG6_105871
Panther	1	1.100	-	-	LDO	PTHR12913
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6011
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910