Protein Alignment Cbl and CBLB

DIOPT Version :10

• Sequence 1: NP_648224.1
• Gene: Cbl / 38961
• FlyBaseID: FBgn0020224
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001308715.1
• Gene: CBLB / 868
• HGNCID: 1542
• Length: 1010
• Species: Homo sapiens
• Alignment Length: 1014
• Identity: 401/1014 - (39%)
• Similarity: 513/1014 - (50%)
• Gaps: 256/1014 - (25%)

  Fly    35 QRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHL--L 97
            ::.:.|::|:|||||||||||:|||.||:.||||||:||||||||||.||||.||.:|...|  |
Human    65 KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQL 129

  Fly    98 HANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVF 162
            ..||:|.::|::||:|.|:||:|||||||:|::|.|..|||||||||:|||||:|:|||||||.|
Human   130 SENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQF 194

  Fly   163 AGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNF 227
            .||.|||||||||:||:..||:.|:||||:|||.|::||.|.|||||||||:||||||||:||.|
Human   195 QGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVF 259

  Fly   228 EFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWA 292
            |||:||||||||.::||||..||||||||:|||||||||||||:|..|.|||:||||||||||||
Human   260 EFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWA 324

  Fly   293 IGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYE 357
            |||||.:|.||||||.||.|.|||:||.||||||||||::|||||:...:....|||.|||||||
Human   325 IGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYE 389

  Fly   358 LYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDA 422
            |||||||||||||||||||||::|||||||:||.|||:|| :|:||||||||.||||||.|:||.
Human   390 LYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQ-ESDGQGCPFCRCEIKGTEPIIVDP 453

  Fly   423 FDPRKQHNRNVT------NGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRL 481
            ||||.:.:|..:      .......::||.|:       :..::.|:........::||.|||..
Human   454 FDPRDEGSRCCSIIDPFGMPMLDLDDDDDREE-------SLMMNRLANVRKCTDRQNSPVTSPGS 511

  Fly   482 G----RRSTTPSLMAVQNDLYAGGTPTLSLP--------------SSSCSSIAAASTSSSSSLAS 528
            .    ||...|..:.:         |.||||              .|.|.|...:..||...:
Human   512 SPLAQRRKPQPDPLQI---------PHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMV-- 565

  Fly   529 VATVAASTSSSQHQQPQPSAPP----------------------------ASAVLSN-------- 557
                      .:..:|.|:.||                            ..:|.|.
Human   566 ----------RKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEA 620

  Fly   558 ------------------GGGGGGGGGASSSQKN---------------TNRMSAPLIGSCV-AN 588
                              |.|....|..:||..|               ..|...||.|:.| :|
Human   621 WCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSN 685

  Fly   589 STYGQK-----------------LPQ-NCSHSSTSSSSDNA------------------------ 611
            ...|.:                 ||. .|:....:|.|:..
Human   686 GHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQ 750

  Fly   612 ------------SSSSSYAILQNLH-------------------DTGTPATAAAVVAPPLPPRKS 645
                        |..:.:.:|...|                   |....|:....:.|..||.:.
Human   751 PSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRD 815

  Fly   646 SPG-----VETPSKATAPPPPSSSKSIDNIQCSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQ 705
            :|.     ..|||......||....:.|.:       ||  :.||.||   |:..:|.|......
Human   816 NPKHGSSLNRTPSDYDLLIPPLGEDAFDAL-------PP--SLPPPPP---PARHSLIEHSKPPG 868

  Fly   706 LIATSTTSPVLSLLDEDIVEVGP-AETISGVIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGS 769
            ..:..::...|.||..|     | .:..||.:...|.........:.:..|..|.||.:.|.|..
Human   869 SSSRPSSGQDLFLLPSD-----PFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQ 928

  Fly   770 AAALANGKKANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCG-TVPYENI 833
            |.|                                .| .:.:|...|....::|..| ....||:
Human   929 APA--------------------------------RP-PKPRPRRTAPEIHHRKPHGPEAALENV 960

  Fly   834 NLEYIARLMNAGYSKENAITALGISRNNIEMAGDILREF 872
            :.: ||:||..||:.|....||.|::||:|:|..|||||
Human   961 DAK-IAKLMGEGYAFEEVKRALEIAQNNVEVARSILREF 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	40..163	CDD:426685	85/124 (69%)
		Cbl_N2	167..250	CDD:460681	60/82 (73%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	76/95 (80%)
		RING-HC_Cbl	346..423	CDD:438368	63/76 (83%)
		COG5222	<368..503	CDD:227547	60/144 (42%)
		UBA_Cbl_like	834..873	CDD:270503	19/39 (49%)
CBLB	NP_001308715.1	Cbl_N	69..195	CDD:426685	85/125 (68%)
		Cbl_N2	199..282	CDD:460681	60/82 (73%)
		SH2_Cbl-b_TKB	276..372	CDD:198176	76/95 (80%)
		RING-HC_Cbl-b	379..454	CDD:438369	63/75 (84%)
		UBA_Cbl-b	959..999	CDD:270575	20/41 (49%)