DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and CBLB

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001308715.1	Gene:	CBLB / 868	HGNCID:	1542	Length:	1010	Species:	Homo sapiens

Alignment Length:	1014	Identity:	401/1014 - (39%)
Similarity:	513/1014 - (50%)	Gaps:	256/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHL--L 97
            ::.:.|::|:|||||||||||:|||.||:.||||||:||||||||||.||||.||.:|...|  |
Human    65 KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQL 129

  Fly    98 HANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVF 162
            ..||:|.::|::||:|.|:||:|||||||:|::|.|..|||||||||:|||||:|:|||||||.|
Human   130 SENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQF 194

  Fly   163 AGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNF 227
            .||.|||||||||:||:..||:.|:||||:|||.|::||.|.|||||||||:||||||||:||.|
Human   195 QGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVF 259

  Fly   228 EFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWA 292
            |||:||||||||.::||||..||||||||:|||||||||||||:|..|.|||:||||||||||||
Human   260 EFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWA 324

  Fly   293 IGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYE 357
            |||||.:|.||||||.||.|.|||:||.||||||||||::|||||:...:....|||.|||||||
Human   325 IGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYE 389

  Fly   358 LYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDA 422
            |||||||||||||||||||||::|||||||:||.|||:|| :|:||||||||.||||||.|:||.
Human   390 LYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQ-ESDGQGCPFCRCEIKGTEPIIVDP 453

  Fly   423 FDPRKQHNRNVT------NGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRL 481
            ||||.:.:|..:      .......::||.|:       :..::.|:........::||.|||..
Human   454 FDPRDEGSRCCSIIDPFGMPMLDLDDDDDREE-------SLMMNRLANVRKCTDRQNSPVTSPGS 511

  Fly   482 G----RRSTTPSLMAVQNDLYAGGTPTLSLP--------------SSSCSSIAAASTSSSSSLAS 528
            .    ||...|..:.:         |.||||              .|.|.|...:..||...:
Human   512 SPLAQRRKPQPDPLQI---------PHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMV-- 565

  Fly   529 VATVAASTSSSQHQQPQPSAPP----------------------------ASAVLSN-------- 557
                      .:..:|.|:.||                            ..:|.|.
Human   566 ----------RKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEA 620

  Fly   558 ------------------GGGGGGGGGASSSQKN---------------TNRMSAPLIGSCV-AN 588
                              |.|....|..:||..|               ..|...||.|:.| :|
Human   621 WCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSN 685

  Fly   589 STYGQK-----------------LPQ-NCSHSSTSSSSDNA------------------------ 611
            ...|.:                 ||. .|:....:|.|:..
Human   686 GHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQ 750

  Fly   612 ------------SSSSSYAILQNLH-------------------DTGTPATAAAVVAPPLPPRKS 645
                        |..:.:.:|...|                   |....|:....:.|..||.:.
Human   751 PSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRD 815

  Fly   646 SPG-----VETPSKATAPPPPSSSKSIDNIQCSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQ 705
            :|.     ..|||......||....:.|.:       ||  :.||.||   |:..:|.|......
Human   816 NPKHGSSLNRTPSDYDLLIPPLGEDAFDAL-------PP--SLPPPPP---PARHSLIEHSKPPG 868

  Fly   706 LIATSTTSPVLSLLDEDIVEVGP-AETISGVIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGS 769
            ..:..::...|.||..|     | .:..||.:...|.........:.:..|..|.||.:.|.|..
Human   869 SSSRPSSGQDLFLLPSD-----PFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQ 928

  Fly   770 AAALANGKKANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCG-TVPYENI 833
            |.|                                .| .:.:|...|....::|..| ....||:
Human   929 APA--------------------------------RP-PKPRPRRTAPEIHHRKPHGPEAALENV 960

  Fly   834 NLEYIARLMNAGYSKENAITALGISRNNIEMAGDILREF 872
            :.: ||:||..||:.|....||.|::||:|:|..|||||
Human   961 DAK-IAKLMGEGYAFEEVKRALEIAQNNVEVARSILREF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	84/122 (69%)
		Cbl_N2	167..250	CDD:280857	60/82 (73%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	76/95 (80%)
		zf-C3HC4_3	367..415	CDD:290631	38/47 (81%)
		UBA_Cbl_like	834..873	CDD:270503	19/39 (49%)
CBLB	NP_001308715.1	Cbl_N	72..195	CDD:280432	84/122 (69%)
		Cbl_N2	199..282	CDD:280857	60/82 (73%)
		SH2_Cbl-b_TKB	276..372	CDD:198176	76/95 (80%)
		RING	401..443	CDD:238093	33/42 (79%)
		UBA_Cbl-b	959..999	CDD:270575	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3488
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	663	1.000	Inparanoid score	I764
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm42138
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4015
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.990