Protein Alignment Cbl and TUL1

DIOPT Version :9

• Sequence 1: NP_648224.1
• Gene: Cbl / 38961
• FlyBaseID: FBgn0020224
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_012890.1
• Gene: TUL1 / 853832
• SGDID: S000001517
• Length: 758
• Species: Saccharomyces cerevisiae
• Alignment Length: 455
• Identity: 94/455 - (20%)
• Similarity: 152/455 - (33%)
• Gaps: 183/455 - (40%)

  Fly    18 PSLLSKLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILD-----ILP 77
            ||:::|    ||..|.|. ::....:|...:.:...||     |::.|    |.::.     ||.
Yeast   424 PSMVNK----ISFYCFSM-INLVDGSLATLYFVAASVV-----PELYL----PLVISAFSCFILA 474

  Fly    78 DTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDEN---------- 132
            ..:: :|.:.|     ::....||. ||.|.||:|           |....:|||
Yeast   475 SIFE-IRYLIS-----IYASQVNEQ-NVGIINLLR-----------GNTGTYDENRPRPAFIPDE 521

  Fly   133 -----SHYRRNLTKLSLVFSHML-------SELKAIFPNGVFAGDQFRITKADAADFWKSNFGNS 185
                 |.|.|....| ::|:.::       .:|:.:|                  ::......||
Yeast   522 GSIGGSLYGRFFFML-IIFTFLILSSTSWPRQLRMVF------------------EYILIFILNS 567

  Fly   186 TLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILA 250
            ..:| :|||   |.|..|.|..|........:.:.|.....:.|.:.|       |::|:..::
Yeast   568 YWIP-QIFR---NAVKGIPSRRERARSSIGGNRSQNKMPLLWSFVIGT-------TIIRSLPVV- 620

  Fly   251 VTHPGYVAFLTYDEVKARLQRYILKAGSYVFR----------LSCTRLGQWAIGYVTAEGEILQT 305
                                 |:....|.|||          ||...|.|.:|.|   ..::|.:
Yeast   621 ---------------------YVFTYSSNVFRHHKDVHFVVFLSLWLLFQISILY---SQDVLGS 661

  Fly   306 ---IPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSP----TEDHITVTQEQYELYCEMG 363
               :|:                :..|||.:|...||:...|.    |.:| ||.
Yeast   662 RWFLPK----------------HTIPDGYSYFKPLSNEYISEHGGGTAEH-TVD----------- 698

  Fly   364 STFQLCKICAENDKDIRIE----------------PCGHLLCTPCLTSWQVDSEGQGCPFCRAEI 412
                 |.||. :|..|.||                ||.|:..|.||.:|.  :....||.||:.:
Yeast   699 -----CAICM-SDVPIYIEEIPETHKVDQHSYMVTPCNHVFHTSCLENWM--NYKLQCPVCRSPL 755

  Fly   413  412
            Yeast   756  755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	29/147 (20%)
		Cbl_N2	167..250	CDD:280857	16/82 (20%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	20/108 (19%)
		zf-C3HC4_3	367..415	CDD:290631	18/62 (29%)
		UBA_Cbl_like	834..873	CDD:270503
TUL1	NP_012890.1	COG5540	320..758	CDD:227827	94/455 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910