DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and RNFT2

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001103373.1	Gene:	RNFT2 / 84900	HGNCID:	25905	Length:	444	Species:	Homo sapiens

Alignment Length:	252	Identity:	55/252 - (21%)
Similarity:	94/252 - (37%)	Gaps:	78/252 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 GNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNW- 246
            ||:..|.:....|:|..        ..:.||..:::.  ||     ||:.      |:..:.::
Human   226 GNTLYVLYTFSSQQLYN--------SLIFLKPNLEML--DF-----FDLL------WIVGIADFV 269

  Fly   247 --------QILAVTHPGYVAFLTYDEVKARLQRY-ILKAGSYVFRLSCTRLGQWAIGYVTAE--- 299
                    :.|.|..|..:.     .||::.:.| :::..|.:|| |...:..| ..|:..:
Human   270 LKYITIALKCLIVALPKIIL-----AVKSKGKFYLVIEELSQLFR-SLVPIQLW-YKYIMGDDSS 327

  Fly   300 -----GEILQTIPQNKSLCQAL-----LDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQE 354
                 |.:|..:   .|||::.     :.|.|:...|....|.|.              :..|.:
Human   328 NSYFLGGVLIVL---YSLCKSFDICGRVGGVRKALKLLCTSQNYG--------------VRATGQ 375

  Fly   355 QYELYC-EMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRA 410
            |    | |.|   .:|.||....::..|..|.|:.|..||..| :|.| :.||.||:
Human   376 Q----CTEAG---DICAICQAEFREPLILLCQHVFCEECLCLW-LDRE-RTCPLCRS 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857	12/75 (16%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	22/118 (19%)
		zf-C3HC4_3	367..415	CDD:290631	16/44 (36%)
		UBA_Cbl_like	834..873	CDD:270503
RNFT2	NP_001103373.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..149
		RING-HC_RNFT2	382..422	CDD:319656	14/41 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910