DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and RAD5

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_197667.1	Gene:	RAD5 / 832338	AraportID:	AT5G22750	Length:	1029	Species:	Arabidopsis thaliana

Alignment Length:	534	Identity:	112/534 - (20%)
Similarity:	174/534 - (32%)	Gaps:	141/534 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FPSLLSKLHGAI-SEAC-VSQRLSTDKKTLEKTWKLM-----------DKVVKLCQQPKMNLKNS 68
            |||.|....|.| ::|. :.:.:.|....|..:||..           |||:    ...::...|
plant   405 FPSTLQMARGGILADAMGLGKTVMTISLLLAHSWKAASTGFLCPNYEGDKVI----SSSVDDLTS 465

  Fly    69 PPFILDILPDTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLF-KEGKEKMFDEN 132
            ||..........:||.       :|..:|....:..|....|:.:.|..|::. |.|...::
plant   466 PPVKATKFLGFDKRLL-------EQKSVLQNGGNLIVCPMTLLGQWKTEIEMHAKPGSLSVY--- 520

  Fly   133 SHYRRNLTKLSLVFSHMLSELKAIFPN-GVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQE 196
            .||.::..|    .:.:||:...:... ||...:..:...||....:        .|.|  ||..
plant   521 VHYGQSRPK----DAKLLSQSDVVITTYGVLTSEFSQENSADHEGIY--------AVRW--FRIV 571

  Fly   197 LNKVHPIISGLEAMALKTTI-------DLTCNDFISNFEFDVFTRL----FQPWVTLLRNWQILA 250
            |::.|.|.:....::|....       .||.....:|.| |:::.|    .:||.|..  |....
plant   572 LDEAHTIKNSKSQISLAAAALVADRRWCLTGTPIQNNLE-DLYSLLRFLRIEPWGTWA--WWNKL 633

  Fly   251 VTHPGYVAFLTYDEVKARLQRYILK-----------------------AGSYV------------ 280
            |..|    |...||...:|.:.|||                       |.:.|
plant   634 VQKP----FEEGDERGLKLVQSILKPIMLRRTKSSTDREGRPILVLPPADARVIYCELSESERDF 694

  Fly   281 ----FRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQ-AYNPDL--- 337
                |:.|..:..|:     ..:|::|........|...|.......|.:...|. |...||
plant   695 YDALFKRSKVKFDQF-----VEQGKVLHNYASILELLLRLRQCCDHPFLVMSRGDTAEYSDLNKL 754

  Fly   338 --------SSAVQS-----PTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLC 389
                    ||.::.     |:|..:....|:.. ..|.|.    |.||.|..:|..:.||.|.||
plant   755 SKRFLSGKSSGLEREGKDVPSEAFVQEVVEELR-KGEQGE----CPICLEALEDAVLTPCAHRLC 814

  Fly   390 TPC-LTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNRNVTNGRQQQQEEDDTEDIGDFN 453
            ..| |.||:..:.|. ||.||..:...|.|...            |..|.|...|.:..:.....
plant   815 RECLLASWRNSTSGL-CPVCRNTVSKQELITAP------------TESRFQVDVEKNWVESSKIT 866

  Fly   454 IATSSLHALSTSST 467
            .....|..|.:|.:
plant   867 ALLEELEGLRSSGS 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	26/133 (20%)
		Cbl_N2	167..250	CDD:280857	20/93 (22%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	25/146 (17%)
		zf-C3HC4_3	367..415	CDD:290631	19/48 (40%)
		UBA_Cbl_like	834..873	CDD:270503
RAD5	NP_197667.1	UBA_like_SF	9..48	CDD:419673
		HIRAN	116..224	CDD:400928
		HepA	<186..1028	CDD:223627	112/534 (21%)
		DEXDc_SHPRH-like	348..660	CDD:350766	63/289 (22%)
		COG5540	<765..837	CDD:227827	24/77 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910