DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and AT5G03450

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_195965.2	Gene:	AT5G03450 / 831835	AraportID:	AT5G03450	Length:	630	Species:	Arabidopsis thaliana

Alignment Length:	498	Identity:	105/498 - (21%)
Similarity:	161/498 - (32%)	Gaps:	107/498 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 NPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQL-CKICAE-----NDKDIRIEPCGHLLCTPC 392
            |.:.|..|.|.:..    :||..|  .:.|.|..| |.||.|     ....:...|||||....|
plant    90 NQNRSQGVCSSSSG----SQEDVE--WKQGDTEGLSCSICMEVWTSGGQHQVCCLPCGHLYGYSC 148

  Fly   393 LTSW-QVDSEGQGCPFC-------------------------------RAEIKGTEQIVVDAFDP 425
            :..| |....|..||.|                               .|:::..||  ..|...
plant   149 INKWFQQRRSGGKCPLCNKICSLRDVRKIYASRVAAVDDEAHKRILFLEAKLRSIEQ--KTASWS 211

  Fly   426 RKQHNRNVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRLGRRSTTPSL 490
            .|:....:|....:.:.....:.|.  |:.:::..:.|.|:..:.||:.|..:........:||.
plant   212 NKEVQWKITEAELRLEVTKLKKKIA--NMESTTKGSQSQSNVASQEKYIPAHNIYQEHHGQSPSC 274

  Fly   491 -MAVQNDLYA---------GGTPTLSLPSSSCSSIAAASTSSSSSLASVATV-------AASTSS 538
             ...|.||..         ||...| |.:...|.:......:..||.|...:       ......
plant   275 SFRHQGDLLINGGRIFDIDGGRQIL-LYARRLSGVGGTFVLTQMSLHSPCEIDDILLPRTTRAIK 338

  Fly   539 SQHQQPQPSAPPASAVLSNGGGGGGGGGASSSQKNTNRMSAPLIGSCVANSTYGQKLPQNCSHSS 603
            ..|..|.          :||....|..|...|          :|.....|:.....||.    :.
plant   339 DLHLSPH----------NNGLAVFGSLGKKLS----------VISLESHNTVLSYDLPA----AP 379

  Fly   604 TSSSSDNASSSSSYAILQN----LHD----TGTPATAAAVVAPPLPPRKSSPGVETPSKATAPPP 660
            .|.|.|..||...||.|||    :.|    ||..|:...:...|:.......|..||:.......
plant   380 WSCSWDLKSSHHIYAGLQNGMVLIFDMRQTTGPFASMTGLTTNPVHTVHHLSGNSTPTSDVRTLL 444

  Fly   661 PSSSKSIDNIQCSLDNVPPQTTAPPIPPHV-SPSVDTLAEDLMRQQLIATSTTSPVLSLLDEDIV 724
            .:||..:    |.. |:.....:|.:.... :|.|...:....|...|..|....|.|  .:|.|
plant   445 SASSIGL----CQW-NISGSEGSPSLVSETGNPGVCISSSYCPRSNHIVASYRPRVGS--SDDTV 502

  Fly   725 EVGPAETISGVIDTRPLEARGVTLC-RQDSASSHYTQLCTTSS 766
            ...|:.|.:||.::......|..:| ::....|:|.:|.:|.:
plant   503 PTQPSLTQTGVSNSNSNGVDGFHVCHKRRGVDSYYQKLSSTQA 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	2/5 (40%)
		zf-C3HC4_3	367..415	CDD:290631	18/85 (21%)
		UBA_Cbl_like	834..873	CDD:270503
AT5G03450	NP_195965.2	mRING-C3HGC3_RFWD3	116..166	CDD:319364	16/49 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910