DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and PEX10

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_565621.1	Gene:	PEX10 / 817175	AraportID:	AT2G26350	Length:	381	Species:	Arabidopsis thaliana

Alignment Length:	215	Identity:	45/215 - (20%)
Similarity:	71/215 - (33%)	Gaps:	70/215 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 RLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAG-------SYVFRLSCTRLGQW 291
            ||.:.|...::.|.::.             .|...:.:.:|:|.       .:.:.:|....|
plant   182 RLMRSWHRAIQRWPVVL-------------PVAREVLQLVLRANLMLFYFEGFYYHISKRASG-- 231

  Fly   292 AIGYVTAEGEILQTIPQNK--------SLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDH 348
             :.||.. |:.|...|:.:        .||....:|.|..            :|||...|..:..
plant   232 -VRYVFI-GKQLNQRPRYQILGVFLLIQLCILAAEGLRRS------------NLSSITSSIQQAS 282

  Fly   349 I-----------TVTQEQYELY---CEMG--------STFQL--CKICAENDKDIRIEPCGHLLC 389
            |           .|..|:..|.   .|.|        ||..:  |.:|....:.....||||:.|
plant   283 IGSYQTSGGRGLPVLNEEGNLITSEAEKGNWSTSDSTSTEAVGKCTLCLSTRQHPTATPCGHVFC 347

  Fly   390 TPCLTSWQVDSEGQGCPFCR 409
            ..|:..|  .:|.|.||.||
plant   348 WSCIMEW--CNEKQECPLCR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857	4/15 (27%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	17/110 (15%)
		zf-C3HC4_3	367..415	CDD:290631	15/45 (33%)
		UBA_Cbl_like	834..873	CDD:270503
PEX10	NP_565621.1	Pex2_Pex12	41..268	CDD:282595	17/102 (17%)
PEX10	NP_565621.1	RING	326..367	CDD:238093	15/42 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910