DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Cblc

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_075713.3	Gene:	Cblc / 80794	MGIID:	1931457	Length:	496	Species:	Mus musculus

Alignment Length:	417	Identity:	199/417 - (47%)
Similarity:	266/417 - (63%)	Gaps:	12/417 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRL----RLIYSKNEDQMHLLHAN 100
            :.:.|.:..||:.::.:.|:.|:|  ...||.:.|:||.|.|.|    :......||......|:
Mouse    14 EPRALSRAVKLLQRLEEQCRDPRM--VTGPPSLRDLLPRTAQLLGEVAKARREAREDPEGPGGAD 76

  Fly   101 EHFNVFINNLMRKCKQAIKLF-----KEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNG 160
            :...:::.||..|.:|..:|.     |:..:.:|.|.|.:||.|.||:|:||||.:||.|:||.|
Mouse    77 DFLAIYLANLEVKGRQVAELLPPRGKKDVNQDVFREGSRFRRQLAKLALIFSHMHAELSALFPAG 141

  Fly   161 VFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFIS 225
            .:.|..:::||..|..||:.|.|...::||..|:..|...||:..|....||::|:|||||..:|
Mouse   142 KYCGHLYQLTKGSAHIFWRQNCGVRCVLPWAEFQSLLCACHPVEPGPTMQALRSTLDLTCNGHVS 206

  Fly   226 NFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQ 290
            .|||||||||||||.|||||||:|||.||||:||||||||:.|||.|..|.|||:||.|||||||
Mouse   207 VFEFDVFTRLFQPWPTLLRNWQLLAVNHPGYMAFLTYDEVQTRLQAYRDKPGSYIFRPSCTRLGQ 271

  Fly   291 WAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQ 355
            ||||||:::|.||||||.||.|.|.||.|.::|.:|:|||:.:||||:...:......|.|::||
Mouse   272 WAIGYVSSDGSILQTIPLNKPLLQVLLKGQKDGIFLFPDGKKHNPDLTELCRVEPYQRIQVSEEQ 336

  Fly   356 YELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVV 420
            ..||..|.|||||||||||.|||:||||||||||:.||.:|| ||:.|.|||||.||||.|.:.:
Mouse   337 LLLYQAMNSTFQLCKICAERDKDVRIEPCGHLLCSCCLAAWQ-DSDSQTCPFCRCEIKGREAVSI 400

  Fly   421 DAFDPRKQHNRNVTNGRQQQQEEDDTE 447
            .....|....|...:|.:....::..|
Mouse   401 CQAQERPTEVRTAADGSRDNCHQEAAE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	42/129 (33%)
		Cbl_N2	167..250	CDD:280857	43/82 (52%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	65/95 (68%)
		zf-C3HC4_3	367..415	CDD:290631	36/47 (77%)
		UBA_Cbl_like	834..873	CDD:270503
Cblc	NP_075713.3	4H	7..144		42/131 (32%)
		Cbl_N	16..144	CDD:280432	42/129 (33%)
		EF-hand-like	145..217		32/71 (45%)
		Cbl_N2	148..231	CDD:280857	43/82 (52%)
		SH2-like	218..320		71/101 (70%)
		SH2_Cbl-b_TKB	225..321	CDD:198176	65/95 (68%)
		Linker. /evidence=ECO:0000250	321..349		10/27 (37%)
		Interaction with RET. /evidence=ECO:0000250	350..494		40/79 (51%)
		RING	350..392	CDD:238093	31/42 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.800