DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and Rnf180

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_038959062.1	Gene:	Rnf180 / 685384	RGDID:	1595064	Length:	601	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	50/220 - (22%)
Similarity:	70/220 - (31%)	Gaps:	49/220 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 GGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAPPA---SAVLSNGGGG 561
            ||...:|.|..||..:||.....|.:..........|..:....|.|..|..   ..:|:.||..
  Rat    95 GGFNFVSTPKCSCGQLAAVHLCKSRTEHQATQAGRLTRPAPKCLPHPGVPSGCDKETLLTGGGSK 159

  Fly   562 GGGGGASSSQKNTNRMSAPLIGSCV-ANSTY----GQKL-------------PQNCSHSSTSSSS 608
            .......|..:|.|.:.......|: ..:||    .:||             ||..:...||.:|
  Rat   160 TRSHRLLSMARNNNGLGRLTEALCLEVRATYFEMKNEKLLFKTSDPKCQPFVPQPDTGRCTSRAS 224

  Fly   609 DNASSSSSYAILQNLHDTGTPATAAAVVAPPLPPRKSSPGVETPSKATAPPPPSSSKSID----N 669
            ...|.|....|.:.|           ::.|.|        .|..||..|.|..:.:..||    .
  Rat   225 HRKSHSLDLNISEKL-----------ILLPTL--------YEIHSKPAAYPRVNETGPIDLSGLA 270

  Fly   670 IQCSLDNVPPQTTAPPIPPHVSPSV 694
            :.||..|...|.     ||...||:
  Rat   271 LPCSKSNCSFQN-----PPSFDPSM 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176
		zf-C3HC4_3	367..415	CDD:290631
		UBA_Cbl_like	834..873	CDD:270503
Rnf180	XP_038959062.1	RING-HC_RNF180	431..474	CDD:319468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910