DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and cbl

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_012822121.1	Gene:	cbl / 594900	XenbaseID:	XB-GENE-6258452	Length:	904	Species:	Xenopus tropicalis

Alignment Length:	957	Identity:	411/957 - (42%)
Similarity:	516/957 - (53%)	Gaps:	197/957 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GTRVQSQPKIFP----SLLSK---------LHGAISEAC-------VSQRLSTDKKTLEKTWKLM 51
            |.||....:..|    ||::.         |.|.:.:|.       .:|..:.|:||:||.||||
Frog    47 GPRVHQPQEFHPAAPRSLVTMATNLRKGGGLIGLVKDAFQPHHHHPTAQPGAVDRKTVEKCWKLM 111

  Fly    52 DKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQ 116
            ||||:|||..::.||||||:|||:||||||.||.|.|:.|.:|.:|..||:|.||:.||::|.||
Frog   112 DKVVRLCQNQRLALKNSPPYILDLLPDTYQHLRTIMSRYEGKMEILGENEYFRVFMENLLKKTKQ 176

  Fly   117 AIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSN 181
            .|.|||||||:|::|||..|||||||||:|||||:|||||||||.|.||.|||||||||:||:..
Frog   177 TISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGQFQGDSFRITKADAAEFWRKA 241

  Fly   182 FGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNW 246
            ||..|:|||||||..|:.||||.|||||||||:||||||||:||.||||:||||||||.:|||||
Frog   242 FGEKTIVPWKIFRLALHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNW 306

  Fly   247 QILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKS 311
            ..||||||||:|||||||||||||::|.|.|||:|||||||||||||||||.:|.||||||.||.
Frog   307 NSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKP 371

  Fly   312 LCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAEND 376
            |.|||:||.||||||:|||:..||||:...:...:|||.||||||||||||||||||||||||||
Frog   372 LFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAEND 436

  Fly   377 KDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPR----KQHNRNVTNGR 437
            ||::|||||||:||.|||||| :||||||||||.||||||.||||.||||    .:..|:..:|.
Frog   437 KDVKIEPCGHLMCTSCLTSWQ-ESEGQGCPFCRCEIKGTEPIVVDPFDPRGGGMAELLRHCMDGT 500

  Fly   438 QQQQEEDDTEDIGDFNI------ATSSLHALSTSSTVAAEKHSPHTSPRLGRRSTTPSLMAVQND 496
            .....:||.:|.|:.:|      |.:.:....:..:...:...|...|||              |
Frog   501 PSPCYDDDDDDSGNDSIFVMKELAGAKVERPPSPLSATPQASLPPVPPRL--------------D 551

  Fly   497 LYAGGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAAST------------------SSSQHQQ 543
            |.....|.   .|.:||...::..||||...........|                  .|...::
Frog   552 LLPQRAPN---QSGACSPATSSKASSSSHHKDKPLPVPPTLRDLPPPPPPDRPHSMPCESRPQRR 613

  Fly   544 PQPSAP------------------------PASAVLSNGGGGGGGGGASSSQKNTNRMSAPLIGS 584
            |.||.|                        |||. |:.|....||      ::.|||.|.|.
Frog   614 PLPSTPAEKPLPLPTNRPGETWHPRAVPKAPASN-LTPGDPWTGG------RELTNRHSLPF--- 668

  Fly   585 CVANSTYGQKLPQNCS-----HSSTSSSSDNASSSSSYAILQNLHDTGTPATAAAVVAPPLPPRK 644
                     .||.:..     |.|| .|.||...|::..:...|.:...          .:.|..
Frog   669 ---------TLPSHIDERRDRHGST-QSLDNTGISATTELFGGLDNDDA----------KMKPSS 713

  Fly   645 SSPGVETPSKATAPPPP----SSSKSIDNIQCSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQ 705
            |:..:.  |.||.||..    .|.:::.||||       |.|.|.:   |.||.:       .:.
Frog   714 SANAIY--SLATRPPDQQTERESYETMYNIQC-------QATNPVV---VEPSRE-------EET 759

  Fly   706 LIATSTTSPVLSLLDEDIVEV-------GPA-ETISGVIDTRPLEARGVTLCRQDSASSHYTQLC 762
            ..|.:...|.....:||..::       .|| .|:|...:..|....|.  ..:||.:.    |.
Frog   760 NSAIANNGPENDDNEEDGYDIPKPHLPMAPARRTMSDAPNATPAFCSGA--IGRDSGAG----LL 818

  Fly   763 TTSSGGSAAALANGKKANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCGT 827
            .:|...........::.||.::|             ..|.||                     |.
Frog   819 ESSQVPERPPKPFPRRMNSERRS-------------VVGGGS---------------------GD 849

  Fly   828 VPYENINLEYIARLMNAGYSKENAITALGISRNNIEMAGDILREFVS 874
            .|...::.| |..|::.|||:::...||.|:.||||||.:|||||||
Frog   850 APPAPLSSE-IESLLSQGYSQQDVNKALLIAHNNIEMARNILREFVS 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	82/120 (68%)
		Cbl_N2	167..250	CDD:280857	62/82 (76%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	74/95 (78%)
		zf-C3HC4_3	367..415	CDD:290631	40/47 (85%)
		UBA_Cbl_like	834..873	CDD:270503	19/38 (50%)
cbl	XP_012822121.1	Cbl_N	102..223	CDD:280432	82/120 (68%)
		Cbl_N2	227..310	CDD:280857	62/82 (76%)
		SH2_Cbl-b_TKB	304..400	CDD:198176	74/95 (78%)
		zf-C3HC4	429..467	CDD:278524	32/38 (84%)
		UBA_c-Cbl	855..894	CDD:270576	19/39 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	665	1.000	Inparanoid score	I757
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm49364
Panther	1	1.100	-	-	LDO	PTHR23007
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060