DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and RNF213

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_005257602.2	Gene:	RNF213 / 57674	HGNCID:	14539	Length:	5256	Species:	Homo sapiens

Alignment Length:	519	Identity:	107/519 - (20%)
Similarity:	175/519 - (33%)	Gaps:	147/519 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIY 87
            |:...:.|..|..:..||.:.|.|      |.|.:.||..:.     .|:..:..:..|.|...|
Human  3763 KIKDYLEELWVQAQYITDAEGLPK------KFVDIFQQTPLG-----RFLAQLHGEPQQELLQCY 3816

  Fly    88 SKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSE 152
            .|:...:.:..:.|....|:...:..|.:.:|...|..|:             ::||.:.|:
Human  3817 LKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEE-------------EVSLPWVHL--- 3865

  Fly   153 LKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKV------HPIISGLEAMA 211
                      |..:||           |...|.:.: ..|:.|.|:.:      |. ::|.| |.
Human  3866 ----------AYQRFR-----------SRLQNFSRI-LTIYPQVLHSLMEARWNHE-LAGCE-MT 3906

  Fly   212 LKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQ-----ILAVTH---PGYVAFLTYDEVKAR 268
            |.....:.|.:.::.   :......|.|:.|::|..     |.:..|   .|.:|.....||:|
Human  3907 LDAFAAMACTEMLTR---NTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQAVIREVRA- 3967

  Fly   269 LQRYILKAGSYVFRLSCTRLGQWAIGYVTA---EGEILQT---IPQNKSLCQALLDGHREGFYLY 327
                                 ||:..:.||   |..:|.|   :|:    .|.|:..|   .:|.
Human  3968 ---------------------QWSRIFSTALFVEHVLLGTESRVPE----LQGLVTEH---VFLL 4004

  Fly   328 PDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTF--QLCKICAENDKDIRIEPCGHLLCT 390
            ......|.|:.:  ..|.|..:....|..|...:..|.|  |.|.||..:.||....||.|:.|.
Human  4005 DKCLRENSDVKT--HGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCL 4067

  Fly   391 PCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDP--RKQHNRNVTNGRQQQQ------------ 441
            .||.:| ..||...||:|...:.       |.|.|  .:.|...:....:.:|
Human  4068 RCLRAW-FASEQMICPYCLTALP-------DEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVST 4124

  Fly   442 ---------EEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHT---SPRLGRRSTTPSLMAV 493
                     |::..|.:      .|.|.........||::|..||   ||.......||.:.:|
Human  4125 ICFKDNAPPEKEVIESL------LSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSV 4182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	20/120 (17%)
		Cbl_N2	167..250	CDD:280857	18/93 (19%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	22/109 (20%)
		zf-C3HC4_3	367..415	CDD:290631	18/47 (38%)
		UBA_Cbl_like	834..873	CDD:270503
RNF213	XP_005257602.2	AAA	2462..2575	CDD:214640
		AAA	2464..2575	CDD:99707
		RING	4046..4084	CDD:238093	16/38 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910