DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and rnf165b

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_005166736.1	Gene:	rnf165b / 572413	ZFINID:	ZDB-GENE-081104-369	Length:	348	Species:	Danio rerio

Alignment Length:	163	Identity:	40/163 - (24%)
Similarity:	61/163 - (37%)	Gaps:	55/163 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 YVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYE-- 357
            |:|:..  |...|:|.:..|.::  |....|.||  |.:...|.|.  ||:. |.|..:|.||
Zfish   190 YLTSPR--LHHFPRNTTSAQVVV--HEIRNYPYP--QLHLLALQSL--SPSR-HATAVRESYEEL 245

  Fly   358 ---------------------------------LYCEMG------STFQLCKIC---AENDKDIR 380
                                             |..::|      .|.:.|.||   .|:::|:|
Zfish   246 LQLEDRLGNVNRGAVQATIERFTFPHKYKKRRPLELKIGMDEEELDTDEKCTICLSMLEDEEDVR 310

  Fly   381 IEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIK 413
            ..||.||....|:..|.  :..:.||.||.:|:
Zfish   311 RLPCMHLFHQACVDQWL--ATNKKCPICRVDIE 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	12/44 (27%)
		zf-C3HC4_3	367..415	CDD:290631	17/50 (34%)
		UBA_Cbl_like	834..873	CDD:270503
rnf165b	XP_005166736.1	zf-RING_2	296..337	CDD:290367	14/42 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910