DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and cblc

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_005158183.1	Gene:	cblc / 565383	ZFINID:	ZDB-GENE-080220-20	Length:	591	Species:	Danio rerio

Alignment Length:	555	Identity:	259/555 - (46%)
Similarity:	352/555 - (63%)	Gaps:	42/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLL---HA 99
            |.|:|.|||..|.:||:.||...|::.||||||::.::|.:|...|..:::........:   ..
Zfish    29 SADRKLLEKVLKRLDKLHKLSVDPRLALKNSPPYLPELLSETAIHLTEVWAPYRGSAMAVPRWDE 93

  Fly   100 NEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAG 164
            .::..:.|.:|:.|..:|:.||||||||||:|.|:||||||||||:|||||:||:.|||.|.|.|
Zfish    94 GDYMRIHIRHLLDKTDRAVLLFKEGKEKMFEETSNYRRNLTKLSLLFSHMLNELRTIFPGGRFQG 158

  Fly   165 DQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEF 229
            |.:|:||.:|.:||:..||:..:|.|.:|:|:|.:||....|:||||||:|:||||||.||.|||
Zfish   159 DTYRVTKTEAKEFWRKTFGHKCIVQWNVFKQQLKRVHYFEEGMEAMALKSTVDLTCNDHISIFEF 223

  Fly   230 DVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIG 294
            |:||||||||.||:|||..||||||||:||||||:|||||:.|..:.|||:||||||::||||||
Zfish   224 DIFTRLFQPWSTLIRNWNHLAVTHPGYMAFLTYDQVKARLEHYRHRPGSYIFRLSCTQMGQWAIG 288

  Fly   295 YVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELY 359
            :||::|.|:||||||..|.|||:.|.|||.||||||:..||||||......:..:.||:||||||
Zfish   289 HVTSDGSIVQTIPQNTPLYQALIQGFREGCYLYPDGRDVNPDLSSLCSPVHKGRVKVTEEQYELY 353

  Fly   360 CEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFD 424
            ||:||||||||||.|.|||.||:|||||||.||||.|| .|:|..||:||.:|:|||.|:::.:.
Zfish   354 CEIGSTFQLCKICTERDKDTRIQPCGHLLCQPCLTGWQ-KSDGHTCPYCRCDIRGTESILIEPYL 417

  Fly   425 PRKQHNRNVTNGRQQQQEEDD-------TEDIGDFNIATSSLHALSTSSTVAAEKHSPHTS---P 479
            |       :.:.|.:::||||       .||..|..:....|..:...|  ..|...|.:|   |
Zfish   418 P-------IRDKRAEEEEEDDEDDDDDEEEDHEDIELVMKKLACMKKIS--QEEYQIPRSSLSPP 473

  Fly   480 RL--GRRSTTPSLMAVQNDLYAGGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAASTSSSQH- 541
            .|  .|.|::|             .|:....:....|:.|....::|...::....:|..|.:|
Zfish   474 PLPPKRNSSSP-------------CPSPKPQTHRSFSLGAQKVKNNSWSENMRRKPSSKRSEEHC 525

  Fly   542 QQPQPSAPPASAVLSNGGGGGGGGGASSSQKNTNR 576
            :..|||:.|.   :.|.|....|...|..:|..::
Zfish   526 EDFQPSSLPC---VRNSGVPWEGPSESVKRKKRDK 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	56/123 (46%)
		Cbl_N2	167..250	CDD:280857	48/82 (59%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	67/95 (71%)
		zf-C3HC4_3	367..415	CDD:290631	32/47 (68%)
		UBA_Cbl_like	834..873	CDD:270503
cblc	XP_005158183.1	Cbl_N	33..157	CDD:308077	56/123 (46%)
		Cbl_N2	161..244	CDD:308414	48/82 (59%)
		SH2_Cbl-b_TKB	238..334	CDD:198176	67/95 (71%)
		RING-HC_Cbl-b	344..409	CDD:319623	47/65 (72%)
		RING-HC finger (C3HC4-type)	363..401	CDD:319623	27/38 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.870