DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and chfr

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001093485.1	Gene:	chfr / 564271	ZFINID:	ZDB-GENE-030131-3522	Length:	637	Species:	Danio rerio

Alignment Length:	296	Identity:	69/296 - (23%)
Similarity:	97/296 - (32%)	Gaps:	72/296 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 GYVTAEGEILQTIPQNKSLCQALLDGHRE---------------GF-YLYPDGQAYNPDLSSAVQ 342
            |..|:.|...||  :.|..|..  ||..|               || ..:.|..|..|...::.:
Zfish   200 GDSTSSGSPAQT--RLKWTCWT--DGEPEEEMQRKRRKTDRDDPGFGSAHSDASADIPLRGASGK 260

  Fly   343 SPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKD-IRIEPCGHLLCTPCLTSWQVDSEGQGCP 406
            ..||...|...|:          ...|.||.:...| |.::||.|..|..|.:.|.  .....||
Zfish   261 EKTEGATTDKMEE----------SLTCIICQDLLYDCISVQPCMHTFCAACYSGWM--ERSSFCP 313

  Fly   407 FCRAEIKGTEQIVVDAFDPRKQH--NRNVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVA 469
            .||..:   |:|       ||.|  |..|.....|..|:..|||         .|.::...:.:.
Zfish   314 TCRCPV---ERI-------RKNHILNNLVEAYLLQHPEKCRTED---------DLRSMDARNKIT 359

  Fly   470 AEKHSPHTSPRLGRRSTTPSLM--AVQNDLYAGGTPTLSLPSSSC-----------SSIAAASTS 521
            .:...|...........:...:  ...||   .....:|.|...|           |::....::
Zfish   360 QDMLQPKVERSFSDEEASSDYLFELSDND---SDISDMSQPYMMCRQCPGYRKELSSALWICESA 421

  Fly   522 SSSSLASVATVAASTSS-SQHQQPQP-SAPPASAVL 555
            .|.|||..|....|||| |....||. ..||.::.|
Zfish   422 QSESLAKTAGDGPSTSSDSTTAAPQEFRCPPQASHL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	15/61 (25%)
		zf-C3HC4_3	367..415	CDD:290631	15/48 (31%)
		UBA_Cbl_like	834..873	CDD:270503
chfr	NP_001093485.1	FHA	10..98	CDD:238017
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..267		17/70 (24%)
		RING	276..319	CDD:238093	15/44 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..447		7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910