DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and CHFR

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001154816.1	Gene:	CHFR / 55743	HGNCID:	20455	Length:	664	Species:	Homo sapiens

Alignment Length:	330	Identity:	58/330 - (17%)
Similarity:	98/330 - (29%)	Gaps:	83/330 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 DGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKD-IRIEPCGHLLCTPC 392
            :.|..:.|:.:|...|.:...|:|                |.||.:...| :.::||.|..|..|
Human   280 NAQTVHEDVRAAAGKPDKMEETLT----------------CIICQDLLHDCVSLQPCMHTFCAAC 328

  Fly   393 LTSWQVDSEGQGCPFCRAEI----------------------KGTEQIVVDAFDPRKQHNRNVTN 435
            .:.|.  .....||.||..:                      |...:..|.:.|.|.:..:::..
Human   329 YSGWM--ERSSLCPTCRCPVERICKNHILNNLVEAYLIQHPDKSRSEEDVQSMDARNKITQDMLQ 391

  Fly   436 ---GRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAE--------KHSPHTSPRLGRRSTTPS 489
               .|....||..:||:.:.:...|....:|....|..:        ...||.....|......:
Human   392 PKVRRSFSDEEGSSEDLLELSDVDSESSDISQPYVVCRQCPEYRRQAAQPPHCPAPEGEPGAPQA 456

  Fly   490 LMAVQNDLYAGGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAPPASAV 554
            |         |..|:.|:..::...........|.:|.:..........::.:|....||...||
Human   457 L---------GDAPSTSVSLTTAVQDYVCPLQGSHALCTCCFQPMPDRRAEREQDPRVAPQQCAV 512

  Fly   555 LSNGGGGGGGGGASSSQKNTNRMSAPLIGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSSSYA- 618
            ..                   :....|...|.....||...| .|..:......|...:::||.
Human   513 CL-------------------QPFCHLYWGCTRTGCYGCLAP-FCELNLGDKCLDGVLNNNSYES 557

  Fly   619 -ILQN 622
             ||:|
Human   558 DILKN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	2/10 (20%)
		zf-C3HC4_3	367..415	CDD:290631	15/70 (21%)
		UBA_Cbl_like	834..873	CDD:270503
CHFR	NP_001154816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		FHA	16..105	CDD:238017
		FHA	<31..140	CDD:224630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..267
		RING	303..346	CDD:238093	15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..417		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..461		5/30 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910