DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and RNF126

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_919442.1	Gene:	RNF126 / 55658	HGNCID:	21151	Length:	311	Species:	Homo sapiens

Alignment Length:	76	Identity:	24/76 - (31%)
Similarity:	35/76 - (46%)	Gaps:	19/76 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 PTEDHITVTQEQYELYCEMGSTFQLCKICAEN---DKDIRIEPCGHLLCTPCLTSW--QVDSEGQ 403
            ||   :.||:|      .:||..: |.:|.::   .:.:|..||.||....|:..|  |.||
Human   214 PT---VPVTEE------HVGSGLE-CPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDS--- 265

  Fly   404 GCPFCRAEIKG 414
             ||.||..:.|
Human   266 -CPVCRKSLTG 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176
		zf-C3HC4_3	367..415	CDD:290631	17/53 (32%)
		UBA_Cbl_like	834..873	CDD:270503
RNF126	NP_919442.1	Required for interaction with BAG6. /evidence=ECO:0000269\|PubMed:24981174	5..100
		zinc_ribbon_9	10..40	CDD:373030
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..132
		Sufficient for interaction with AICDA. /evidence=ECO:0000269\|PubMed:23277564	200..304		24/76 (32%)
		RING-H2_RNF126	228..271	CDD:319715	15/47 (32%)
		RING-H2 finger (C3H2C3-type)	229..269	CDD:319715	14/43 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910