DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and cblb

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_001921961.4	Gene:	cblb / 556277	ZFINID:	ZDB-GENE-030616-417	Length:	939	Species:	Danio rerio

Alignment Length:	994	Identity:	409/994 - (41%)
Similarity:	518/994 - (52%)	Gaps:	186/994 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATRGSGTRVQSQPKIFPSLLSKLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNL 65
            |||..||....::......::..:..|:..   .::.:.|::|:|||||||||||:|||.|::.|
Zfish     1 MATALSGRPPNNRKGRILGIIDAIQDAVGP---PKQAAADRRTVEKTWKLMDKVVRLCQNPRLQL 62

  Fly    66 KNSPPFILDILPDTYQRLRLIYSKNEDQMHL--LHANEHFNVFINNLMRKCKQAIKLFKEGKEKM 128
            |||||:||||||||||.||||..|.|:...|  |..|::|.|:|::||:|.|:||:||||.||:|
Zfish    63 KNSPPYILDILPDTYQHLRLILCKYEENQRLTQLSENDYFKVYIDSLMKKSKRAIRLFKEAKERM 127

  Fly   129 FDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIF 193
            ::|.|..|||||||||:|||||:|:|||||.|.|.||.|||||||||:||:.:||..|:||||:|
Zfish   128 YEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQGDTFRITKADAAEFWRRSFGEKTIVPWKMF 192

  Fly   194 RQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVA 258
            ||.|:.||||.|||||||||:||||||||:||.||||:||||||||.::||||..||||||||:|
Zfish   193 RQCLHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMA 257

  Fly   259 FLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREG 323
            ||||||||||||:||.|.|||:|||||||||||||||||::|.||||||.||.|.|||:||.|||
Zfish   258 FLTYDEVKARLQKYINKPGSYIFRLSCTRLGQWAIGYVTSDGNILQTIPHNKPLFQALIDGCREG 322

  Fly   324 FYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLL 388
            |||:|||::|||||:...:....|||.||||||||||||||||||||||||||||::|||||||:
Zfish   323 FYLFPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM 387

  Fly   389 CTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQ-----HNRNVTNGRQQQQEEDDTED 448
            ||.|||||| ||:||||||||.||||||.|:||.||||.:     |..:.::......::||.:.
Zfish   388 CTSCLTSWQ-DSDGQGCPFCRCEIKGTEPIIVDPFDPRNEGAKCFHLDHFSSPLLDPDDDDDRDG 451

  Fly   449 I-------GDFNIATSSLHALSTSST-----VAAEKHSPHTS-----PRLGR-RSTTPSLMA--- 492
            :       ....|..|.:.:.::|..     .||:...||.:     |||.. ||..||..|
Zfish   452 LLVIDHIKKSMEIQNSPIMSPNSSPVCERRKTAADHMGPHLNIPPVPPRLDLIRSPAPSPTASPK 516

  Fly   493 ------------------VQND------------LYAGG------TPTLSLPSSSCSSIAAASTS 521
                              .|.|            |...|      ||:..||....:.:.|.|..
Zfish   517 SSPGMSRKQDKPLPAPPPPQRDPPPPPPPERPPHLPQEGRAAWLVTPSSGLPRDPRAPLEAWSPK 581

  Fly   522 SSSSLASVATVAASTSSS-QHQQP-QPSAPPASAVLSNGGGGGGGGGASSSQKNTNRM------S 578
            .|::|:...|.||..|.. .|..| ..:..|.|...::.|            .|.||:      |
Zfish   582 DSTALSDCRTSAADRSPKLAHAAPAHINERPLSCSSADLG------------LNRNRLIAQTECS 634

  Fly   579 APLIGSCVANSTYG--------QKLPQNCSH--------SSTSSSSDNASSSSSYAILQNLHDTG 627
            ...:...:....|.        ..|..|..|        |.|....|:....||:.:.
Zfish   635 KSFVNGLLPGDEYDIPPLRHSPPILDNNQRHMNPFTSPRSLTDRVEDDYQIPSSHPVC------- 692

  Fly   628 TPATAAAVVAPPLPPRKS----SPGVETPSKATAPPP-------PSSSKSIDNIQCSLDNVPPQT 681
              .|..|:..|...|.::    |....|..|...||.       |..|......||.|.|..|..
Zfish   693 --ITQPAICIPFRIPNRALENGSTDHSTDIKKHKPPEHGGFDSGPLISAVSHTTQCPLHNRTPSD 755

  Fly   682 TAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSPVLSLLDEDIVEVGPAETISGVIDTRPLEARGV 746
            ....:||..||         |.....|...:.|            .|...|....
Zfish   756 YDILLPPQASP---------MEDPFNALPPSQP------------PPPPPIRNSF---------- 789

  Fly   747 TLCRQDSASSHYTQLCTTSSGGSAAALANGKKANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQ 811
               .:.|:||.|.:....|||.....|:.....:|...|    ..|......|..|...|.:..|
Zfish   790 ---TEASSSSLYPRPARPSSGHDHFLLSPDTFIDSLNNS----APSPPVRRQTGDNMKTPFRAPQ 847

  Fly   812 PLLYANVTINQKDCGTVP-----------------------YENINLEYIARLMNAGYSKENAIT 853
            .......|....||...|                       .||::.: ||:||..|||.|:...
Zfish   848 DYDQLPPTSVAGDCFRAPERPPKPLPRIIPPDIHRRPHESSRENVDAK-IAKLMGEGYSFEDVKR 911

  Fly   854 ALGISRNNIEMAGDILREF 872
            ||.|::|.:::|.:|||||
Zfish   912 ALMIAQNKVDVARNILREF 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	80/122 (66%)
		Cbl_N2	167..250	CDD:280857	61/82 (74%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	76/95 (80%)
		zf-C3HC4_3	367..415	CDD:290631	40/47 (85%)
		UBA_Cbl_like	834..873	CDD:270503	18/39 (46%)
cblb	XP_001921961.4	Cbl_N	39..162	CDD:280432	80/122 (66%)
		Cbl_N2	166..249	CDD:280857	61/82 (74%)
		SH2_Cbl-b_TKB	243..339	CDD:198176	76/95 (80%)
		RING	368..410	CDD:238093	35/42 (83%)
		UBA_Cbl-b	891..931	CDD:270575	19/41 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3428
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	661	1.000	Inparanoid score	I742
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm24271
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.960