DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and rnf130

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_009289393.1	Gene:	rnf130 / 553950	ZFINID:	ZDB-GENE-050522-525	Length:	428	Species:	Danio rerio

Alignment Length:	199	Identity:	46/199 - (23%)
Similarity:	78/199 - (39%)	Gaps:	63/199 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 FQLCKICAE----NDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIV-----VD 421
            |..|.:|.|    ||. :||.||.|:....|:..|.  :|...||.|:..|.....::     ||
Zfish   270 FNHCAVCIEGYQLNDV-VRILPCKHVFHKMCVDPWL--NEHCTCPMCKLNILKALGVMPNLPCVD 331

  Fly   422 --AFDPRKQHNRNVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAE--KHSPHTSPRLG 482
              |||..:. :|:.|:.::                  ::|..||:.::::.|  :||
Zfish   332 NMAFDMDRM-SRSQTSSQR------------------TALVDLSSETSISLEPLRHS-------- 369

  Fly   483 RRSTTPSLMAVQNDLYAGGTPTLSLPSSSCSSIA-------AASTSSSSSLASVATVAASTSSSQ 540
            ..|..||    ..:|         :|.|...:||       .||....|:|.....:..:|:|:.
Zfish   370 SSSQLPS----DEEL---------IPRSGEINIAVTKEWFIVASFGVLSALTLCYMIIRATASTT 421

  Fly   541 HQQP 544
            :.:|
Zfish   422 NYEP 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176
		zf-C3HC4_3	367..415	CDD:290631	17/51 (33%)
		UBA_Cbl_like	834..873	CDD:270503
rnf130	XP_009289393.1	PA_GRAIL_like	49..188	CDD:239037
rnf130	XP_009289393.1	zf-RING_2	271..314	CDD:290367	15/45 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910