DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and rnf4

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001016554.1	Gene:	rnf4 / 549308	XenbaseID:	XB-GENE-1016982	Length:	188	Species:	Xenopus tropicalis

Alignment Length:	186	Identity:	37/186 - (19%)
Similarity:	58/186 - (31%)	Gaps:	56/186 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 PGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEILQTI------------ 306
            ||..|.:|     |..:...|::|..|..|:|.......:.....:..|..::
Frog    22 PGSTAAMT-----AATEPIELESGEEVVDLTCESTEPVVVDLTNNDLSINDSVVIVEDTPRQRRA 81

  Fly   307 ----PQNKSLCQALLDG----HREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMG 363
                .|..:.|....|.    |.:.|       |.|.|:||.....:..               .
Frog    82 LSRPSQQTTSCVLSSDDEDSRHADHF-------AANKDISSQAYGSSRS---------------S 124

  Fly   364 STFQLCKICAENDKDI----RI---EPCGHLLCTPCLTSWQVDSEGQGCPFCRAEI 412
            |....|.||.::..:|    |:   ..|||:.|:.||.  ........||.||.::
Frog   125 SGKVSCPICMDSYSEIVQSGRLIVSTKCGHIFCSQCLR--DALKNAPSCPTCRKKL 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	20/105 (19%)
		zf-C3HC4_3	367..415	CDD:290631	15/53 (28%)
		UBA_Cbl_like	834..873	CDD:270503
rnf4	NP_001016554.1	zf-RING_2	129..175	CDD:290367	13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910