DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Cbl

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_576396.3	Gene:	Cbl / 500985	RGDID:	1561386	Length:	914	Species:	Rattus norvegicus

Alignment Length:	944	Identity:	415/944 - (43%)
Similarity:	519/944 - (54%)	Gaps:	188/944 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEH 102
            :.|||.:||.||||||||:|||.||:.||||||:|||:||||||.||.:.|:.|.:|..|..||:
  Rat    49 TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEY 113

  Fly   103 FNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQF 167
            |.||:.|||:|.||.|.|||||||:|::|||..|||||||||:|||||:|||.|||:|:|.||.|
  Rat   114 FRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTF 178

  Fly   168 RITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVF 232
            ||||||||:||:..||..|:||||.|||.|::||||.|||||||||:||||||||:||.||||:|
  Rat   179 RITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIF 243

  Fly   233 TRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVT 297
            |||||||.:|||||..||||||||:|||||||||||||::|.|.|||:|||||||||||||||||
  Rat   244 TRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVT 308

  Fly   298 AEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEM 362
            |:|.||||||.||.|.|||:||.||||||:|||:..||||:...:...:|||.||||||||||||
  Rat   309 ADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEM 373

  Fly   363 GSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRK 427
            ||||||||||||||||::|||||||:||.|||||| :||||||||||.||||||.||||.||||.
  Rat   374 GSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQ-ESEGQGCPFCRCEIKGTEPIVVDPFDPRG 437

  Fly   428 QHN--RNVTNGRQQQQEEDDTEDIGDFN------IATSSLHALSTSSTVAAEKHSPHTSPRLGRR 484
            ..:  |....|......:||.::..|.:      :|.:.:...|:..::|.:...|...|||
  Rat   438 SGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRL--- 499

  Fly   485 STTPSLMAVQNDLYAGGTPTLSLPSSSCSSIAAASTSSSSSL----------------------- 526
                       ||.....|   :|:|: |.:..||.:|||||
  Rat   500 -----------DLLQQRAP---VPAST-SVLGTASKASSSSLHKDKPLPIPPTLRDLPPPPPPDR 549

  Fly   527 -ASVAT-----------VAASTSSSQHQQPQPSAPPASAVLS-----------NGGGGGGGGGAS 568
             .||.|           ......|.....|.||:.|..:.||           |.|....|
  Rat   550 PYSVGTETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNG---- 610

  Fly   569 SSQKNTNRMSAPL--------------IGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSSSYAI 619
              ::.|||.|.|.              :||..:..|           |:|.:||..|...|.
  Rat   611 --RELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDT-----------STTMNSSPVAGPESE--- 659

  Fly   620 LQNLHDTGTPATAA----AVVAPPLPPRKSSPGVE----------TP-SKATAPPPPSSSKSIDN 669
                |....|:::|    ::.|.|||..|..||.:          || |:......|...:..:.
  Rat   660 ----HPKIKPSSSANAIYSLAARPLPVPKLPPGEQGDSEEDTEYMTPTSRPVGVQKPEPKRPAET 720

  Fly   670 IQ----CSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTS--PVLSLLDEDIVEVGP 728
            .|    |..|......|...:....|.::.........:..:||:.||  |..|..::|..:| |
  Rat   721 AQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSACGEGNLATAHTSTGPEESENEDDGYDV-P 784

  Fly   729 AETISGVIDTRPLEARGVTLCRQDSASSHYTQLC-----TTSSGGSAA----------ALANGKK 778
            ...:..|:..|       ||....:|||.:..|.     |..:.||..          .:.:.:|
  Rat   785 KPPVPAVLARR-------TLSDISNASSSFGWLSLDGEPTNFNEGSQVPERPPKPFPRRINSERK 842

  Fly   779 ANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCGTVPYENINLEYIARLMN 843
            |:|.:|........||||                                |...::.| |.|||:
  Rat   843 ASSYQQGGGAMANPAAAA--------------------------------PSPQLSSE-IERLMS 874

  Fly   844 AGYSKENAITALGISRNNIEMAGDILREFVSKNS 877
            .|||.::...||.|:.||||||.:|||||||.:|
  Rat   875 QGYSYQDIQKALVIAHNNIEMAKNILREFVSISS 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	81/120 (68%)
		Cbl_N2	167..250	CDD:280857	62/82 (76%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	75/95 (79%)
		zf-C3HC4_3	367..415	CDD:290631	40/47 (85%)
		UBA_Cbl_like	834..873	CDD:270503	21/38 (55%)
Cbl	XP_576396.3	Cbl_N	53..174	CDD:280432	81/120 (68%)
		Cbl_N2	178..261	CDD:280857	62/82 (76%)
		SH2_Cbl-b_TKB	255..351	CDD:198176	75/95 (79%)
		RING	380..422	CDD:238093	35/41 (85%)
		UBA_c-Cbl	865..904	CDD:270576	17/24 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3380
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	665	1.000	Inparanoid score	I719
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm46285
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	LDO	PTHR23007
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.820