DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and cbl

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001007331.1	Gene:	cbl / 492364	ZFINID:	ZDB-GENE-041114-207	Length:	913	Species:	Danio rerio

Alignment Length:	932	Identity:	398/932 - (42%)
Similarity:	521/932 - (55%)	Gaps:	156/932 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEH 102
            :.||||:||.||.|||||:|||.||:.||||||:|||:||||||.||.|.|:.|.:|..|..||:
Zfish    34 AVDKKTVEKCWKFMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGDNEY 98

  Fly   103 FNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQF 167
            |.||:.||.:|.||.|.|||:|||:||:|||..|||||||||:|||||:|||||||||:|.||.|
Zfish    99 FRVFMENLTKKTKQTISLFKDGKERMFEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNF 163

  Fly   168 RITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVF 232
            ||||||||:||:.:||:.|:||||:|||.|::.|||.|||||||||:||||||||:||.||||:|
Zfish   164 RITKADAAEFWRRSFGDKTIVPWKVFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIF 228

  Fly   233 TRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVT 297
            |||||||.:|||||..||||||||:|||||||||||||::|.|.|||:|||||||||||||||||
Zfish   229 TRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVT 293

  Fly   298 AEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEM 362
            |:|.||||||.||.|.||.:||.||||||:|||:..||||:...:...:|||.||||||||||||
Zfish   294 ADGNILQTIPHNKPLFQAHIDGFREGFYLFPDGRTQNPDLTGLCEPSPQDHIKVTQEQYELYCEM 358

  Fly   363 GSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRK 427
            ||||||||||||||||::|||||||:||.|||:|| :||||||||||.||||||.||||.|||:.
Zfish   359 GSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQ-ESEGQGCPFCRCEIKGTEPIVVDPFDPKD 422

  Fly   428 QHN------RNV--TNGRQQQQEEDDTEDIGD---FNIAT---SSLHALSTSSTVAAEKHSPHTS 478
            .::      |.:  ..|......:||.:|..:   |.|:.   |.:....:..:::.:...|...
Zfish   423 PNSAASYGCRGMFGAEGAPSPSYDDDDDDRLEETPFMISKLVGSKVERPPSPMSISPQPVVPPVP 487

  Fly   479 PRL----------------GRRSTTPS--------LMAVQNDLYAGGTPTLSLPSSSCSSI---A 516
            |||                |..|..||        |.....||.....|....|:.:.:.:   .
Zfish   488 PRLDLLPLRPTNPPGASSPGATSKAPSHHKDKPLPLPPALRDLPPPPPPDRPHPAGADNRLPRRP 552

  Fly   517 AASTSSSSSLASVATVAASTS----SSQHQQPQPSAPPASAVLSNGGGGGGGGGASSSQKNTNRM 577
            ..||....|...:.....:.:    :|:.....||.||||            |....|::.:||.
Zfish   553 LPSTPGDPSRDKLPPAPPNRNMPDWNSRPVPKAPSQPPAS------------GDTRGSRELSNRH 605

  Fly   578 SAPL-IGSCVANSTYGQKL--PQNCSHSSTSSSSDNASSSSSYAILQNLHDTGTPATAA----AV 635
            |.|| :.|.:.:.|...:.  |.:..|..:..||:.||...|..:        .|:.:|    ::
Zfish   606 SLPLQLPSTLDSRTEAPRNNGPPSLDHQLSFGSSNPASDYDSPKV--------KPSASANAIYSL 662

  Fly   636 VAPPLPPRKSSPGVET------------------PS---KATAPPPPSSSKSIDNIQCSLDNVPP 679
            ...|:...::..|.||                  ||   :|...|||..|.|..::...|::..|
Zfish   663 AIRPVAAARTQTGEETNENDEESEYMTPSSRPVLPSAAGEAVPRPPPPLSLSPRSMLNELESESP 727

  Fly   680 QTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSPVLSLLDEDIVEV-------GPAETISGVID 737
            |                :.|.:...|..|.:.::|  ...|.|..|:       ||.:.:....:
Zfish   728 Q----------------MYEAMYNIQAQALTASAP--QARDSDYSELPPLTCSNGPRDPVGAYAE 774

  Fly   738 TRPLE---------------ARGVTLCRQDSASSHYTQLCTTSSGGSAAALANGKKANSAKQSQA 787
            ....|               ||.........:||.:::|...|..|:||.:.:..:|........
Zfish   775 EEEEEENSYDYPKPHLSAALARRTLSDANSPSSSAFSRLSFDSDLGAAATVLDPSEAPERPPKPL 839

  Fly   788 TTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCGTVPYENINLEYIARLMNAGYSKENAI 852
            ....::....:....|::||                     |.:.|:.| |..|::.|||.::..
Zfish   840 PRRINSDRRPSPVPPGASPG---------------------PSQQISSE-IEHLLSQGYSHQDIQ 882

  Fly   853 TALGISRNNIEMAGDILREFVS 874
            .||.|::||||||.::||||||
Zfish   883 KALMIAQNNIEMAKNVLREFVS 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	83/120 (69%)
		Cbl_N2	167..250	CDD:280857	61/82 (74%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	74/95 (78%)
		zf-C3HC4_3	367..415	CDD:290631	39/47 (83%)
		UBA_Cbl_like	834..873	CDD:270503	18/38 (47%)
cbl	NP_001007331.1	Cbl_N	38..159	CDD:280432	83/120 (69%)
		Cbl_N2	163..246	CDD:280857	61/82 (74%)
		SH2_Cbl-b_TKB	240..336	CDD:198176	74/95 (78%)
		RING	365..407	CDD:238093	34/42 (81%)
		UBA_c-Cbl	864..903	CDD:270576	19/39 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3428
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	661	1.000	Inparanoid score	I742
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm24271
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	LDO	PTHR23007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4015
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.950