DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and cblb

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001006802.1	Gene:	cblb / 448509	XenbaseID:	XB-GENE-1018102	Length:	982	Species:	Xenopus tropicalis

Alignment Length:	1011	Identity:	406/1011 - (40%)
Similarity:	535/1011 - (52%)	Gaps:	238/1011 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LHGAISEAC-VSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIY 87
            |..||.:|. ..::.:.|::|:|||||||||||:|||.||:.||||||:||||||||||.||||.
Frog    36 LFDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLIL 100

  Fly    88 SKNEDQMHL--LHANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHML 150
            ||.:|...|  |..||:|.::|::||:|.|:||:|||||||:|::|.|..|||||||||:|||||
Frog   101 SKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQERRNLTKLSLIFSHML 165

  Fly   151 SELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTT 215
            :|:|||||:|.|.||.|||||||||:||:..||..|:||||||||.|::||.|.|||||||||:|
Frog   166 AEIKAIFPSGQFQGDNFRITKADAAEFWRKFFGERTIVPWKIFRQCLHEVHQISSGLEAMALKST 230

  Fly   216 IDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYV 280
            |||||||:||.||||:||||||||.::||||..||||||||:|||||||||||||:|..|.|||:
Frog   231 IDLTCNDYISVFEFDIFTRLFQPWTSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYI 295

  Fly   281 FRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPT 345
            ||||||||||||||||||:|.||||||.||.|.|||:||.||||||||||::|||||:...:...
Frog   296 FRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTDLCEPTP 360

  Fly   346 EDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRA 410
            .|||.||||||||||||||||||||||||||||::|||||||:||.|||||| :|:||||||||.
Frog   361 HDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQ-ESDGQGCPFCRC 424

  Fly   411 EIKGTEQIVVDAFDPRKQH-----NRNVTNGRQQQQEEDDTEDIGDFNIATSSLHALS--TSSTV 468
            ||||||.||||.||||.::     |.::........::|..|:....| ..:||..::  .:|.|
Frog   425 EIKGTEPIVVDPFDPRDENRCCSFNDSLCTPMLDFDDDDLREECLIMN-RLASLRKMNERQNSPV 488

  Fly   469 AAEKHSPHTSPRLGRRSTTPSLMAVQNDLYAGGTPTLSLP--------------SSSCSSIAAAS 519
            .    ||.:||...||.|.|..:.:         |.|:||              .|.|:|...:.
Frog   489 T----SPGSSPLSQRRKTPPDPLQI---------PHLNLPPVPPRLDLIQKGLARSPCASPTGSP 540

  Fly   520 TSSSSSLASV-ATVAASTSSSQHQQPQPSAPPASAVLSNGGGGGGGGGASSSQKNTNRMSAPLIG 583
            .||...:... ..:.|.....:...|.|..||                           ..|...
Frog   541 KSSPCMVRKQDKPLPAPPPPLREPPPPPERPP---------------------------PIPPDS 578

  Fly   584 SCVANSTYGQKLPQNCSHSSTSSS---SDNASSSSSYAILQNLHDTGTP---------------- 629
            ....:..:.:.:|  |...||...   :.:.|.:|..:|.:..|| |:|
Frog   579 RTCRHLHHTENVP--CRDQSTQHDAWCTRDISGASQPSICRVAHD-GSPKLGVPSSSVLNGRHSR 640

  Fly   630 -ATAAAVVAPPLPPRKSSPGVETPSKATAPPPPSSSKSIDNIQCSLDNVPPQTTAPPIPPHVS-- 691
             :|.|..:......|:.|| :||......   .|.::..|        |||:.:.||.||.::
Frog   641 MSTEAGFIRHKHHKRRESP-LETIRVYNG---LSGNEEYD--------VPPRLSPPPPPPTITIH 693

  Fly   692 PSVDTLAEDLMRQQLIATSTTSPVLSLLDEDIVEVGPAETISGVIDTRPLEARGVTLCRQDSASS 756
            |::        :..|:..|.:..|.:..:||..|.       .:..:.|:.:|....|.   :..
Frog   694 PAI--------KCPLLVNSVSDKVRNSAEEDDSEY-------KIPSSHPVSSRLPLHCH---SIK 740

  Fly   757 HYTQLCTTS---SGGSAAALANGKKANSAKQSQ--ATTT------TSAAAAAATAGNGS------ 804
            |:.:||...   |.|:...::..||.....|..  ||:|      ::..:|.....:||
Frog   741 HFPRLCENGQCLSNGTHNGISEIKKLKQPDQGDVIATSTVPVPLPSARTSARENHPHGSSLTRTP 805

  Fly   805 --------NPGQQS------------------------------------------------QPL 813
                    :||::|                                                .||
Frog   806 SDYDLLVPHPGEESFDSSPPSQPPPPPPARTCVPEHAMPTASGCRPNSDVDLFLPHSDPCPEAPL 870

  Fly   814 LYA--------NVTINQK--------DCGTVP--------------------------YENINLE 836
            ..|        :..::|:        ||...|                          .||::.:
Frog   871 PPARRGPGEAKSNRLSQEYDQLPSCPDCPQAPARPPKPVPRRTAPEIHHRRHYNCDSLAENVDAK 935

  Fly   837 YIARLMNAGYSKENAITALGISRNNIEMAGDILREF 872
             ||:||..|:..|....||.|::||:::|..|||||
Frog   936 -IAKLMGEGFPFEEVKRALEIAQNNVDVARSILREF 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	83/122 (68%)
		Cbl_N2	167..250	CDD:280857	61/82 (74%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	77/95 (81%)
		zf-C3HC4_3	367..415	CDD:290631	39/47 (83%)
		UBA_Cbl_like	834..873	CDD:270503	17/39 (44%)
cblb	NP_001006802.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		4H	46..178		84/131 (64%)
		Cbl_N	55..176	CDD:367006	82/120 (68%)
		EF-hand-like	179..251		54/71 (76%)
		Cbl_N2	182..265	CDD:367171	61/82 (74%)
		SH2-like	252..354		81/101 (80%)
		SH2_Cbl-b_TKB	259..353	CDD:198176	76/93 (82%)
		Linker	355..383		19/27 (70%)
		RING-HC_Cbl-b	365..430	CDD:319623	56/65 (86%)
		RING-HC finger (C3HC4-type)	384..422	CDD:319623	31/38 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..582		25/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..728		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..911		17/144 (12%)
		UBA_Cbl-b	931..971	CDD:270575	18/41 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	665	1.000	Inparanoid score	I757
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm49364
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4015
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090