DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and rnf141

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001007291.2	Gene:	rnf141 / 414846	ZFINID:	ZDB-GENE-040625-71	Length:	222	Species:	Danio rerio

Alignment Length:	223	Identity:	53/223 - (23%)
Similarity:	79/223 - (35%)	Gaps:	92/223 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 VTHPGYV---AFLTYDE----------VKARL----QRYIL---KAGS-------YVFRLSCTRL 288
            :.|.|.|   .:|||||          |.|:|    ::::|   :.||       ...|:.||::
Zfish    18 IKHVGLVRDSGYLTYDEFLGRVAELNDVTAKLASGQKKHLLFEVQPGSDSSALWKVAVRIVCTKI 82

  Fly   289 GQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREG---FYLYPDGQAYNPDLSS----------A 340
                                ||.      ||..|.   ..||...|.|. |::|          |
Zfish    83 --------------------NKE------DGMVEASRIMNLYQFIQLYK-DITSQAAEVFSSNVA 120

  Fly   341 VQSPTEDHITVTQEQYELYCE----MGSTFQL-----CKICAENDKDIRIEPCGHLLCTPCLTSW 396
            .:..:||           .|:    ||...||     |.||.:...|: |.||.|..|..|:..|
Zfish   121 AEGSSED-----------TCQASMWMGRVKQLTDEEECCICMDGKADL-ILPCAHSFCQKCIDKW 173

  Fly   397 QVDSEGQGCPFCRAEIKGTEQ--IVVDA 422
              ..:.:.||.||.::....:  ::.||
Zfish   174 --SGQSRNCPVCRIQVTAANESWVMSDA 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	28/128 (22%)
		zf-C3HC4_3	367..415	CDD:290631	17/52 (33%)
		UBA_Cbl_like	834..873	CDD:270503
rnf141	NP_001007291.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910