DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and CG6923

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	111/506 - (21%)
Similarity:	175/506 - (34%)	Gaps:	170/506 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 EDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRA 410
            |:|     .||.:|...           :.|.:      |::|.||.|:|.|..|..:..|...|
  Fly    32 ENH-----SQYAMYYNQ-----------QRDSE------GYMLMTPFLSSSQSHSHTRSPPTYTA 74

  Fly   411 EIKGTEQIVVDAFDPRKQHNRNVTNGRQQQQEEDDTEDIG----DFNIATSSLHALST------- 464
            .:           :||::.:... .|..::.::..:.| |    :..:|:||.:|.||
  Fly    75 MV-----------EPRREESSGF-EGLARRCDKCSSLD-GLCRCESMVASSSRYADSTQNQSHSE 126

  Fly   465 -------SSTVAAEKHSP--HTSPRLGRRSTTPSLMAVQND--------LYAGGTPTLSLPSSSC 512
                   ||:.||..:.|  |:.||..|:.|.|..|..::|        ..:|..|..::...:.
  Fly   127 AQFLEQPSSSTAAIANPPAVHSIPRPKRKKTEPLTMEPESDNDGDAVVASVSGTWPAGAIEEHAM 191

  Fly   513 SSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAPPA-SAVLSNGGGGGGGGGASSSQKNTNR 576
            .|.|......||||      ..|.||.   :..|||..| ..|.|:......|..|.:...||..
  Fly   192 DSTAVVYEVPSSSL------QLSNSSF---ETAPSAVNAYDDVTSSASDTEHGQFAHTRTTNTTT 247

  Fly   577 MSAPLIGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSSSYAILQNLHDT-GTPATAAAVVAPPL 640
            .::.:                 .:|...:|.|:|||::||.|:     || .||:|:|
  Fly   248 TTSAV-----------------QAHKKKASRSNNASNTSSRAV-----DTDATPSTSA------- 283

  Fly   641 PPRKSSPGVETPSKATAPPPPSSSKSIDNIQCSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQ 705
            ..||......:..|:....|.:.| |.|.....:.|        |:|| :.|:|          .
  Fly   284 QSRKRQMSQFSYRKSRVLEPENES-SDDGWDLRVHN--------PVPP-IEPTV----------T 328

  Fly   706 LIATSTTSPVLSLLDEDIVEVGPAETISGVIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGSA 770
            :|..|..|        |..|:|..:                        .::|...|..     |
  Fly   329 IIRGSRGS--------DEAEIGHTD------------------------HNYYNSRCAV-----A 356

  Fly   771 AALANGKKANSAKQSQATTTTSA----------AAAAATAGNGSNPGQQSQ 811
            .|..:.....||..|.||.||.:          :||..:....|:..|:.|
  Fly   357 GAPPDSTYIRSASCSTATHTTRSVDYGSRIGRRSAATGSPSTSSDQEQEQQ 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176
		zf-C3HC4_3	367..415	CDD:290631	11/47 (23%)
		UBA_Cbl_like	834..873	CDD:270503
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910