DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and rnft1

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_998393.2	Gene:	rnft1 / 406509	ZFINID:	ZDB-GENE-040426-2324	Length:	419	Species:	Danio rerio

Alignment Length:	236	Identity:	46/236 - (19%)
Similarity:	81/236 - (34%)	Gaps:	85/236 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 WQILAVTHPGYVAFLTYD---------------------EV--KARLQRYILKAGSYVFR----- 282
            |.:|.:|....:.|.|:.                     ||  ...:..:|||   ::|.
Zfish   191 WLLLFLTSSSLLVFYTFHTQSLYRCLFFANATIDYHNFWEVLWSVGVTNFILK---FIFMGFKCL 252

  Fly   283 --------LSCTRLGQW-----AIG--------------YVTAEGEILQTIPQNKSLCQALLDGH 320
                    ::..|.|||     .:|              |:.:..|:..::.....:..|||...
Zfish   253 ILLVPCPLMTYRRRGQWYMLIEEVGQLYQVIAPVPLWFRYLVSYDEMDTSVGLTLGILLALLYLI 317

  Fly   321 REGFYLYP-DGQA-------YNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDK 377
            .:...||. .|..       ::|:::.|..||.:..            |.|   .:|.||..:.|
Zfish   318 MKLLALYGLSGSLQKTLRTFFSPEVNGAPASPAQIR------------EAG---DICPICQADFK 367

  Fly   378 DIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQI 418
            ..|:..|.|:.|..|:..|.  ::.:.||.||..|  |:::
Zfish   368 QPRVLVCQHIFCEECIAQWL--NQERTCPLCRTVI--TDKV 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857	1/3 (33%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	25/156 (16%)
		zf-C3HC4_3	367..415	CDD:290631	15/47 (32%)
		UBA_Cbl_like	834..873	CDD:270503
rnft1	NP_998393.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120
		Required for ubiquitin ligase activity and for protection against ER stress-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q5M7Z0	352..403		18/69 (26%)
		RING	359..400	CDD:238093	14/42 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910