DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and Amfr

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_038954087.1	Gene:	Amfr / 361367	RGDID:	1311551	Length:	643	Species:	Rattus norvegicus

Alignment Length:	181	Identity:	41/181 - (22%)
Similarity:	66/181 - (36%)	Gaps:	49/181 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 CKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNRNV 433
            |.||.::.:..|..|||||....||.||.  .:...||.||..:                   |:
  Rat   341 CAICWDSMQAARKLPCGHLFHNSCLRSWL--EQDTSCPTCRMSL-------------------NI 384

  Fly   434 TNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRLGRRSTTPSLMAVQNDLY 498
            .:| .:.:|:...|:: |.|:.          ...|||..     |||.:.:   ..........
  Rat   385 ADG-SRAREDHQGENL-DENLV----------PVAAAEGR-----PRLNQHN---HFFHFDGSRI 429

  Fly   499 AGGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAP 549
            |...|:.|:.....::|...:.:|:|.|.::|        .|.|:..|..|
  Rat   430 ASWLPSFSVEVMHTTNILGITQASNSQLNAMA--------HQIQEMFPQVP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176
		zf-C3HC4_3	367..415	CDD:290631	17/45 (38%)
		UBA_Cbl_like	834..873	CDD:270503
Amfr	XP_038954087.1	HRD1	86..>382	CDD:227568	17/42 (40%)
		RING-H2_AMFR	339..382	CDD:319369	17/42 (40%)
		CUE_AMFR	458..498	CDD:270604	5/23 (22%)
		G2BR	575..600	CDD:375868
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910