DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and AgaP_AGAP005449

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_556087.3	Gene:	AgaP_AGAP005449 / 3289969	VectorBaseID:	AGAP005449	Length:	878	Species:	Anopheles gambiae

Alignment Length:	913	Identity:	568/913 - (62%)
Similarity:	644/913 - (70%)	Gaps:	88/913 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RVQSQPKIFPSLLSKLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFIL 73
            |.:.||:...|..||:.|.||:||..|:..||||||||||||||||||||||.||||||||||||
Mosquito     6 RARPQPRANISFFSKIQGKISDACAQQKFLTDKKTLEKTWKLMDKVVKLCQQSKMNLKNSPPFIL 70

  Fly    74 DILPDTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRN 138
            ||||||||||.|||||.||||||||:|||:|:|||||||||||||||||||||||||||||||||
Mosquito    71 DILPDTYQRLHLIYSKYEDQMHLLHSNEHYNIFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRN 135

  Fly   139 LTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPI 203
            ||||||||||||||||||||||:||||||||||||||:|||:.||||||||||:||.||:.||||
Mosquito   136 LTKLSLVFSHMLSELKAIFPNGLFAGDQFRITKADAAEFWKTRFGNSTLVPWKLFRFELSLVHPI 200

  Fly   204 ISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKAR 268
            .||||||||||||||||||:||||||||||||||||.||||||||||||||||||||||||||||
Mosquito   201 SSGLEAMALKTTIDLTCNDYISNFEFDVFTRLFQPWNTLLRNWQILAVTHPGYVAFLTYDEVKAR 265

  Fly   269 LQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAY 333
            ||:||.|||||||||||||||||||||||.||||||||||||||||||||||||||||||||:..
Mosquito   266 LQKYITKAGSYVFRLSCTRLGQWAIGYVTQEGEILQTIPQNKSLCQALLDGHREGFYLYPDGKPN 330

  Fly   334 NPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQV 398
            |||||.|||||.||||||||||||||||||:||||||||||||||||||||||||||||||:|||
Mosquito   331 NPDLSFAVQSPLEDHITVTQEQYELYCEMGTTFQLCKICAENDKDIRIEPCGHLLCTPCLTAWQV 395

  Fly   399 DSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNRNVTNGRQQQQ---EEDDTEDIGDFNIATSSLH 460
            |||||||||||||||||||||||||||::|||||..|||||.|   .:|||||  ||||||||||
Mosquito   396 DSEGQGCPFCRAEIKGTEQIVVDAFDPKRQHNRNSANGRQQLQNDDHDDDTED--DFNIATSSLH 458

  Fly   461 ALSTSSTVAA---EKHSPHTSPRLGRR---------------------STTPSLMAVQ-NDLY-A 499
            |||.|.|:|.   :|.|||:||||.||                     |..||...:. :|:| |
Mosquito   459 ALSNSMTLARNNNDKQSPHSSPRLPRRQQQHQQQQQQQQQPPSSCPPTSQAPSAPVLSGSDIYAA 523

  Fly   500 GGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAPPASAVLSNGGGGGGG 564
            ||:|   ||.::.::..::|.||.:.:|| |.||||.::.....|..|:.|:|...|:     ..
Mosquito   524 GGSP---LPPTAGTTTTSSSNSSGNLVAS-APVAASCNACPGSHPPSSSSPSSTTTSS-----SS 579

  Fly   565 GGASSSQKNTNRMSAPLIGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSS----SYAILQNLHD 625
            ..:|||..:|:..|:                    |.|||||||...||||    :.|:....|.
Mosquito   580 SSSSSSSSSTSSSSS--------------------STSSTSSSSSTTSSSSCASGAAALTVASHP 624

  Fly   626 T-GTPATAAA---VVAPPLPPRKSSPGVETPSKAT-------APPPPSSSKSIDNIQCSLDNVPP 679
            . .|||..||   ...|||||||||||:...|.|:       |.....|::::.::..|    |.
Mosquito   625 ALSTPAAIAAACTTTPPPLPPRKSSPGILAASAASDHRQQKLAGCSSGSNRNLPSLAAS----PH 685

  Fly   680 QTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSP-VLSLLDEDIVEVGPAETISGVIDTRPLEA 743
            ....||:|.|     ..:|:....||..::::..| .......|.|.|||||||.|:|||||.||
Mosquito   686 PPAPPPVPKH-----QNIAQQHQHQQQPSSASGDPFAAGDTATDKVIVGPAETIVGIIDTRPPEA 745

  Fly   744 RGVTLCRQDSASSHYTQLCTTSSGGSAAALANGKKANSAKQSQATTTTSAAAAAATAGNGSNPGQ 808
            |...:.:.|..:.....|....:..:....|.|.|......|::.|::..||:||..|..|....
Mosquito   746 RHPIILKVDEKADQSLILTAALTPNNVYHAAVGAKILPHPPSKSITSSQLAASAAGGGGRSGTPS 810

  Fly   809 QSQPLLYANVTINQKDCGTVPYENINLEYIARLMNAGYSKENAITALGISRNNIEMAGDILREFV 873
            ...|||.|   :|..:...|||||||||||||||..||||||.||||||||||||||.|||.|||
Mosquito   811 AGHPLLSA---LNNNNNPNVPYENINLEYIARLMQEGYSKENVITALGISRNNIEMACDILHEFV 872

  Fly   874 SKN 876
            ||:
Mosquito   873 SKS 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	113/120 (94%)
		Cbl_N2	167..250	CDD:280857	72/82 (88%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	89/95 (94%)
		zf-C3HC4_3	367..415	CDD:290631	46/47 (98%)
		UBA_Cbl_like	834..873	CDD:270503	33/38 (87%)
AgaP_AGAP005449	XP_556087.3	Cbl_N	39..160	CDD:280432	113/120 (94%)
		Cbl_N2	164..247	CDD:280857	72/82 (88%)
		SH2_Cbl-b_TKB	241..335	CDD:198176	87/93 (94%)
		zf-C3HC4_3	364..412	CDD:290631	46/47 (98%)
		SPATA3	454..>562	CDD:292290	42/111 (38%)
		UBA_Cbl_like	833..872	CDD:270503	33/38 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	243	1.000	Domainoid score	I5049
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134395
Inparanoid	1	1.050	880	1.000	Inparanoid score	I1194
OMA	1	1.010	-	-		QHG26117
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		oto110998
Panther	1	1.100	-	-	LDO	PTHR23007
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2221
TreeFam	0	0.000	Not matched by this tool.
	10	10.070