Protein Alignment Cbl and Lonrf2

DIOPT Version :9

• Sequence 1: NP_648224.1
• Gene: Cbl / 38961
• FlyBaseID: FBgn0020224
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_006244931.1
• Gene: Lonrf2 / 301361
• RGDID: 1562137
• Length: 753
• Species: Rattus norvegicus
• Alignment Length: 581
• Identity: 113/581 - (19%)
• Similarity: 171/581 - (29%)
• Gaps: 211/581 - (36%)

  Fly   255 GYVAFLTYD-EVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLD 318
            |..|||..| ||.|.|.|.:|...:...|..|.:||:    .:...|.:.:.|           .
  Rat    28 GSAAFLAGDYEVAAELFRSLLAGLAQPERGLCLQLGE----ALARAGRLPEAI-----------G 77

  Fly   319 GHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAEN------DK 377
            ..|....|.|    ..|...|.:.|.....:.:.:::..:....|.       ||..      .:
  Rat    78 AFRGAALLGP----LQPGELSELASGLARALGLREKRPPVAARPGG-------CASGTSGPVAPR 131

  Fly   378 DIRIEP-CGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNR-NV------- 433
            |:...| ||.||..|...|       .|...|:   :..||:.|     |.|..| ||
  Rat   132 DLLGCPRCGRLLYKPVTLS-------SGLTVCK---RCVEQVPV-----RAQARRVNVVLSGLLE 181

  Fly   434 ---------------TNGRQQQQEE-----------DDTEDIGDFNIATSSLH--------ALST 464
                           ..|.|:||:.           |...|.....:..:.|:        ||..
  Rat   182 RCFPAECRLRRLACQARGLQRQQQPEAALLRCQQALDMAPDDSSLLLLRAELYLTMKNYEQALQD 246

  Fly   465 SSTVAAEK----HSPHTSPR----LGRRSTTPSLMAVQNDLYAGGTPTLSLPSSSCSSIAAASTS 521
            :.||...:    ...|...:    |||...     .::..:|.     |:| :..|:|      :
  Rat   247 ADTVCQREPLLTKGHHIKAQILSGLGRNKE-----VLKEFIYC-----LAL-NPECNS------A 294

  Fly   522 SSSSLASVATVAASTSSSQHQQPQPSAPPASAVLSNG--------GGGGGGGGASSSQKNTNRMS 578
            ...:...:..|..|.|.::.|...||.......|.:|        ...||...|.|.:..:.:..
  Rat   295 KKETQKVICEVFFSASENEQQNSAPSTQTGPKALCDGQMSPQNPLEEAGGHANADSPKTPSEKPD 359

  Fly   579 APLIGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSSSYAILQNLH--------DTGTPATAAAV 635
            .|                            :|.:||..|.|| .||        :...||..:..
  Rat   360 VP----------------------------ENTNSSVLYFIL-GLHCEEDKKALEGVIPAAPSGT 395

  Fly   636 VAPPLP--PRKSSPGVETPSKATAPPPPSSSKSIDNIQCSLDNVP-------------------- 678
            :...||  .......|.||.|.......||.:...|   ||:..|
  Rat   396 LKRQLPSDAEDKELDVNTPEKIPKKDADSSPQRNAN---SLEEEPEFTIDATDFECALCMRLLFE 457

  Fly   679 PQTTAPPI---------------PPHVSPSVDTLAEDLMRQQLIATSTTSPVLSLLDEDIV 724
            |.||  |.               .||.....|.|:|      |:||...:  :::|.|:::
  Rat   458 PVTT--PCGHTFCLKCLERCLDHAPHCPLCKDKLSE------LLATRNFN--VTVLTEELI 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	21/85 (25%)
		zf-C3HC4_3	367..415	CDD:290631	12/54 (22%)
		UBA_Cbl_like	834..873	CDD:270503
Lonrf2	XP_006244931.1	TPR_16	25..90	CDD:290168	20/80 (25%)
		TPR repeat	25..49	CDD:276809	10/20 (50%)
		TPR repeat	56..85	CDD:276809	7/43 (16%)
		TPR repeat	223..253	CDD:276809	5/29 (17%)
		TPR repeat	258..281	CDD:276809	4/27 (15%)
		RING	447..486	CDD:238093	6/40 (15%)
		LON	527..732	CDD:271862
		LON_substr_bdg	537..737	CDD:280370

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910