DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Cblc

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001030092.1	Gene:	Cblc / 292699	RGDID:	1307651	Length:	497	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	207/483 - (42%)
Similarity:	280/483 - (57%)	Gaps:	46/483 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMH-----LLHA 99
            :.:.|.:..||:.::.:.|:.  :.|...||.:.|:||.|.|.||.:.....|:..     ...|
  Rat    14 EPRALGRAVKLLQRLEEQCRD--LRLFVGPPSLRDLLPRTAQLLREVAKARSDKTRGDPEGPGGA 76

  Fly   100 NEHFNVFINNLMRKCKQAIKLF-----KEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPN 159
            .:...:::.||..|.:|..:|.     |:..:.:|.|.|.:||.|.||:|:||||.:||.|:||.
  Rat    77 GDFLVIYLTNLEAKGRQVAELLPHRGKKDANQDVFPEGSRFRRQLAKLALIFSHMHAELSALFPE 141

  Fly   160 GVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFI 224
            |.:.|..::|||..|..||:.|.|...::||..|:..|...||:..|....||::|:||||:..:
  Rat   142 GKYCGHLYQITKGSANTFWRENCGVRCVLPWAEFQSLLCSCHPVEPGPIMQALRSTLDLTCSGHV 206

  Fly   225 SNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLG 289
            |.||||:||||||||.|||:|||:|||.||||:||||||||:.|||.|..|.|||:||.||||||
  Rat   207 SVFEFDIFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQTRLQAYRDKPGSYIFRPSCTRLG 271

  Fly   290 QWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQE 354
            |||||||::.|.||||||.||.|.|.||.|.::|.:|||||:.:||||:...::.....|.|:||
  Rat   272 QWAIGYVSSNGSILQTIPLNKPLLQVLLKGQKDGIFLYPDGKNHNPDLTELCRAELNQCIQVSQE 336

  Fly   355 QYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIV 419
            |.:||..|.|||:|||||.|.|||:||||||||||:.||.:|| .|:.|.|||||.||||.|.:.
  Rat   337 QLQLYQAMNSTFELCKICTERDKDVRIEPCGHLLCSCCLAAWQ-HSDSQTCPFCRCEIKGREAVS 400

  Fly   420 VDAFDPRKQHNRNVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSS------------------ 466
            :.....|....|....         |:.|......|...|.:::.|:
  Rat   401 ICQAQERSMEVRTTAG---------DSGDNCHQEAAEWKLESVTPSAPPLPPEVPCPQRPQDKGW 456

  Fly   467 -TVAAEKHSPHTSPRLGRRSTTPSLMAV 493
             |:|     |.|.|||......|.:.:|
  Rat   457 LTLA-----PFTLPRLRPPLPLPKMASV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	41/130 (32%)
		Cbl_N2	167..250	CDD:280857	41/82 (50%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	65/95 (68%)
		zf-C3HC4_3	367..415	CDD:290631	33/47 (70%)
		UBA_Cbl_like	834..873	CDD:270503
Cblc	NP_001030092.1	4H	7..145		41/132 (31%)
		Cbl_N	16..145	CDD:280432	41/130 (32%)
		EF-hand-like	146..218		31/71 (44%)
		Cbl_N2	149..232	CDD:280857	41/82 (50%)
		SH2-like	219..321		71/101 (70%)
		SH2_Cbl-b_TKB	226..322	CDD:198176	65/95 (68%)
		Linker. /evidence=ECO:0000250	322..350		11/27 (41%)
		Interaction with RET. /evidence=ECO:0000250	351..497		50/144 (35%)
		RING	351..393	CDD:238093	29/42 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.800