DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and pas4

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_595592.1	Gene:	pas4 / 2539774	PomBaseID:	SPBC17A3.10	Length:	306	Species:	Schizosaccharomyces pombe

Alignment Length:	286	Identity:	53/286 - (18%)
Similarity:	101/286 - (35%)	Gaps:	108/286 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGL 207
            ||:|| ::.:|..:..|.:       :.:|..:..:|..||...|:|..:..:|.:.|: |::..
pombe   100 SLIFS-LVIDLVGVHVNKL-------LKQASYSSSFKLPFGLRNLLPEAVISKEKHLVY-ILNSF 155

  Fly   208 EAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVA----------FLTY 262
            :.:.||.                         |:::|   .|.:|..|:.|          :::.
pombe   156 KPILLKL-------------------------VSIIR---FLCLTMKGHCATVSQLLLGLKYISL 192

  Fly   263 DEV----KARLQRYILKAGS----YVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDG 319
            ||:    |.::...:|..||    .:.:.|.:...|..|..:|.|.::     ::|:....:.:|
pombe   193 DEINPEEKKKVLTLLLLLGSRLIASILQHSNSYFDQHTISSITDERDL-----EDKNKLPFIPEG 252

  Fly   320 HREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPC 384
            :|:                                     |.:...|..|....|         |
pombe   253 NRK-------------------------------------CSLCMEFIHCPAATE---------C 271

  Fly   385 GHLLCTPCLTSWQVDSEGQGCPFCRA 410
            ||:.|..|:..|  .|:...||.|||
pombe   272 GHIFCWSCINGW--TSKKSECPLCRA 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	6/19 (32%)
		Cbl_N2	167..250	CDD:280857	13/82 (16%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	19/113 (17%)
		zf-C3HC4_3	367..415	CDD:290631	14/44 (32%)
		UBA_Cbl_like	834..873	CDD:270503
pas4	NP_595592.1	PEX10	1..306	CDD:227861	53/286 (19%)
pas4	NP_595592.1	RING	255..295	CDD:238093	14/87 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910