DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and CBLC

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_011524990.1	Gene:	CBLC / 23624	HGNCID:	15961	Length:	493	Species:	Homo sapiens

Alignment Length:	508	Identity:	211/508 - (41%)
Similarity:	299/508 - (58%)	Gaps:	59/508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHA----- 99
            :.:.|.:..:::.::.:.|..|::::  |||.:.|:||.|.|.||       :..|...|
Human    14 EARALGRAVRMLQRLEEQCVDPRLSV--SPPSLRDLLPRTAQLLR-------EVAHSRRAAGGGG 69

  Fly   100 -------NEHFNVFINNLMRKCKQAIKLF-----KEGKEKMFDENSHYRRNLTKLSLVFSHMLSE 152
                   .:...:::.||..|.:|...|.     :...:::|...|..||.|.||:::||||.:|
Human    70 PGGPGGSGDFLLIYLANLEAKSRQVAALLPPRGRRSANDELFRAGSRLRRQLAKLAIIFSHMHAE 134

  Fly   153 LKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTID 217
            |.|:||.|.:.|..:::|||.|..||:.:.|...::||..|...|...||:..|..|:||:||||
Human   135 LHALFPGGKYCGHMYQLTKAPAHTFWRESCGARCVLPWAEFESLLGTCHPVEPGCTALALRTTID 199

  Fly   218 LTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFR 282
            |||:..:|.|||||||||||||.|||:|||:|||.||||:||||||||:.|||....|.|||:||
Human   200 LTCSGHVSIFEFDVFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQERLQACRDKPGSYIFR 264

  Fly   283 LSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTED 347
            .|||||||||||||:::|.||||||.||.|.|.||:|.::||||||||:.:||||:...|:..:.
Human   265 PSCTRLGQWAIGYVSSDGSILQTIPANKPLSQVLLEGQKDGFYLYPDGKTHNPDLTELGQAEPQQ 329

  Fly   348 HITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEI 412
            .|.|::||.:||..|.|||:|||||||::||::|||||||||:.||.:|| .|:.|.|||||.||
Human   330 RIHVSEEQLQLYWAMDSTFELCKICAESNKDVKIEPCGHLLCSCCLAAWQ-HSDSQTCPFCRCEI 393

  Fly   413 KGTEQIVVDAFDPRKQHNRNVT--NGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSP 475
            ||.|.:.:..|     |.:...  :|....||..:.| :|...::...|            ...|
Human   394 KGWEAVSIYQF-----HGQATAEDSGNSSDQEGRELE-LGQVPLSAPPL------------PPRP 440

  Fly   476 HTSPRLGRRSTTP-SLMAVQNDLYAGGTPTLSLP--SSSCSSIAAASTSSSSS 525
            ...||..|.:... :|:|:         |.|..|  .....::|:|:..::||
Human   441 DLPPRKPRNAQPKVALLAL---------PRLRAPLLLPRIKAVASAAQEATSS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	37/137 (27%)
		Cbl_N2	167..250	CDD:280857	44/82 (54%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	66/95 (69%)
		zf-C3HC4_3	367..415	CDD:290631	32/47 (68%)
		UBA_Cbl_like	834..873	CDD:270503
CBLC	XP_011524990.1	Cbl_N	16..145	CDD:280432	37/137 (27%)
		Cbl_N2	149..232	CDD:280857	44/82 (54%)
		SH2_Cbl-b_TKB	226..322	CDD:198176	66/95 (69%)
		RING	351..393	CDD:238093	28/42 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940