DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cbl and Rfwd3

DIOPT Version :9

Sequence 1:NP_648224.1 Gene:Cbl / 38961 FlyBaseID:FBgn0020224 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_666330.2 Gene:Rfwd3 / 234736 MGIID:2384584 Length:774 Species:Mus musculus


Alignment Length:519 Identity:109/519 - (21%)
Similarity:170/519 - (32%) Gaps:129/519 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 QSPTEDHITVTQEQYELYCEMGSTFQLCKICAE---NDKDIRIEP--CGHLLCTPCLTSWQVDSE 401
            :||.:.::....|.     |.|.|   |.||.|   |..|.||..  ||||....|::.| :..:
Mouse   269 ESPQKPNMLSAMED-----EEGET---CTICLEQWTNAGDHRISALRCGHLFGFRCISKW-LKGQ 324

  Fly   402 GQGCPFCRAEIKGTEQIVV-----DAFDP----------------RKQHNRNVTNGRQQQQEEDD 445
            .:.||.|..:.|.::.:|:     .|.|.                |||........|.|.|...|
Mouse   325 TRKCPQCNKKAKHSDIVVIYARSLRALDTSEQERMKSDLLNEQMLRKQAELESAQCRLQLQVLID 389

  Fly   446 --------TEDIGDFNI--ATSSLHALSTSSTVAAEKHSPHTSPRLGRRSTTPSLMAVQND---- 496
                    .:|:..|.:  ..|:....|.|..:..:..|...||  |:.|:..:....|..    
Mouse   390 KCTKLNSRVQDLEKFVVRHQNSAAQQCSRSKALCGKCLSSSQSP--GKYSSEKTFTISQTGKCRI 452

  Fly   497 -LYAGGTPTLSLPSSSCSSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAPPASAVLSNGGG 560
             .|..|...|         :|:..:..:|.|........||::.:..|..|........||    
Mouse   453 LAYCDGLSCL---------VASQPSPQASFLPGFGVKMLSTANMKSSQYIPMHNKQIRGLS---- 504

  Fly   561 GGGGGGASSSQKNTNRMSAPL-----IGSCVANS---TYGQKLP-QNCSHSSTSSSSDNASSSSS 616
                   .|||.....:||.|     :.|...|:   ||....| .:|......::...|..:|.
Mouse   505 -------FSSQSKGLLLSASLDCTIKLTSLETNTVVQTYNTGRPVWSCCWCLDENNYVYAGLASG 562

  Fly   617 YAILQNLHDTGTPATAAAVVAPPLPPRKSSPGVE---TPSKATAPPPPSS--SKSIDN-----IQ 671
            ..::.:|.:|.|      .:...:|.:...|.|.   .|..|.|..|...  :.:::|     ::
Mouse   563 SILIYDLRNTNT------YIQELVPQKARCPLVSLSYLPKAAVAAFPYGGVLAGTLENASFWELK 621

  Fly   672 CSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQLI------ATSTTSPVLSLLDEDIVEVG--- 727
            ....:.|...:..|     ...||...|...|..|:      :.:|...||..:...:.:.|   
Mouse   622 SDFSHKPHVLSLEP-----GGFVDFQTESSTRHCLVTYRPDKSHNTVRTVLLEMSYKLDDAGEPV 681

  Fly   728 ----PAETISG----------VIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGSAAALANGK 777
                |.:|..|          .|...|.....|.:|..|.||    |.....:.||...|.|.|
Mouse   682 CSCLPVQTFLGGPTCKLLTKSAIFQSPENNGNVLVCTGDEAS----QSTLLWNAGSGLLLQNLK 741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CblNP_648224.1 Cbl_N 42..163 CDD:280432
Cbl_N2 167..250 CDD:280857
SH2_Cbl-b_TKB 244..340 CDD:198176
zf-C3HC4_3 367..415 CDD:290631 18/52 (35%)
UBA_Cbl_like 834..873 CDD:270503
Rfwd3NP_666330.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..126
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..281 2/11 (18%)
RING 287..334 CDD:238093 18/50 (36%)
WD40 451..>571 CDD:295369 27/139 (19%)
WD40 <486..>626 CDD:225201 29/156 (19%)
WD 1 493..535 11/52 (21%)
WD40 repeat 501..537 CDD:293791 11/46 (24%)
WD 2 536..568 5/31 (16%)
WD40 repeat 542..582 CDD:293791 6/45 (13%)
WD 3 583..628 7/44 (16%)
WD40 repeat 590..644 CDD:293791 9/58 (16%)
WD40 repeat 701..741 CDD:293791 12/43 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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