DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and Chfr

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001276506.1	Gene:	Chfr / 231600	MGIID:	2444898	Length:	664	Species:	Mus musculus

Alignment Length:	320	Identity:	70/320 - (21%)
Similarity:	104/320 - (32%)	Gaps:	89/320 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 VTAEGEI--LQTIPQNKSLCQALLDG--HRE----------------GFYLYPDGQAYN-----P 335
            :.|.||:  |..:.|:|....:||:.  |.|                ...|...||..|     .
Mouse   221 LVANGELSSLSPVFQDKEASFSLLESKDHEELEPAKKKMKGDGELDTNLQLLVSGQRGNAQTSSE 285

  Fly   336 DLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKD-IRIEPCGHLLCTPCLTSWQVD 399
            |:..|...|.:...|:|                |.||.:...| :.::||.|..|..|.:.|.
Mouse   286 DVKDASVKPDKMEETLT----------------CIICQDLLHDCVSLQPCMHTFCAACYSGWM-- 332

  Fly   400 SEGQGCPFCRAEIKGTEQI--------VVDAF------------DPRKQHNRN-VTNG------- 436
            .....||.||..:   |:|        :|:|:            |.|....|| :|..
Mouse   333 ERSSLCPTCRCPV---ERICKNHILNNLVEAYLIQHPDKSRSEEDVRSMDARNKITQDMLQPKVR 394

  Fly   437 RQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRLGRRSTTPSLMAVQNDLYAGG 501
            |....||..:||:.:.:...|....:|....|..:      .|.. ||....||.....:...|.
Mouse   395 RSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQ------CPEY-RRQAVQSLPCPVPESELGA 452

  Fly   502 TPTL--SLPSSSCSSIAAA-----STSSSSSLASVATVAASTSSSQHQQPQPSAPPASAV 554
            |..|  ..||:|.|...||     ....|.::.:..........::.:|....||...||
Mouse   453 TLALGGEAPSTSASLPTAAPDYMCPLQGSHAICTCCFQPMPDRRAEREQDPRVAPQQCAV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	15/68 (22%)
		zf-C3HC4_3	367..415	CDD:290631	14/48 (29%)
		UBA_Cbl_like	834..873	CDD:270503
Chfr	NP_001276506.1	FHA	16..105	CDD:238017
		FHA	<27..140	CDD:224630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..220
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..264		2/18 (11%)
		RING	302..345	CDD:238093	15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..413		5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910