DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and Dzip3

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001103487.1	Gene:	Dzip3 / 224170	MGIID:	1917433	Length:	1204	Species:	Mus musculus

Alignment Length:	511	Identity:	92/511 - (18%)
Similarity:	159/511 - (31%)	Gaps:	183/511 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SQRLSTDKKTLEK--------TWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKN 90
            |.:.|||.|..||        .:||..:    |:..|..||.        :...:|..:::..|.
Mouse   738 SGKESTDFKETEKERLAHQHQLYKLQYE----CEDYKRQLKT--------VTFRWQENQMLIKKK 790

  Fly    91 EDQMHLLHANEHFNVFINNLMRKCKQAIKL----FKEGKEKMFDENSHYRRNLTKLSLVFSHMLS 151
            |..:..|:....|.:   |.|.|.::.|..    .|..|:::..:.|.:......|.......|:
Mouse   791 EKIIVSLNQQVAFGI---NKMSKLQRQIHAKDDEIKNLKDQLSLKRSQWEMEKHNLESTVKTYLN 852

  Fly   152 ELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKV----HPIISGLEAMAL 212
            :|.|.....:.|...|...:.|        ||...|...:  ::.||::    |...|.||::.|
Mouse   853 KLNAETSRALTAEVYFLQCRRD--------FGLLHLEQTE--KECLNQLARVTHMAASNLESLQL 907

  Fly   213 KTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFL--TYDE----------- 264
            |..:|                           :|..:.......:|||  .|:|
Mouse   908 KAAVD---------------------------SWNAIVADVRNKIAFLRTQYNEQINKVKQGFAL 945

  Fly   265 ------------------VKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGE---------- 301
                              ::..|.|.::|...:...|:..::.....|.::|..:
Mouse   946 STLPPVQLPPPPPSPEILIQQFLGRPLVKESFFRPILTVPQMPAVCPGVISAAVQPRPPLMPGIT 1010

  Fly   302 ------ILQTIPQNKSLC-------------------------------QALLDGHREGF----- 324
                  |..|:..:.|||                               |.|.|.|.:..
Mouse  1011 WAMPTPIGDTVSPSASLCSEPLMINWERITDRLKTAFPQQTRKELTDFLQQLKDSHGKSVSRLTF 1075

  Fly   325 --YLYPDGQAYNPDLSSAVQSPTED-------HITVTQ---EQYELYCEMGSTF----------- 366
              .:|...|...|..|.:.:...:|       | |.:|   .|.....:..:|:
Mouse  1076 DEIVYKISQMIEPKKSESEEKSAQDGNNASPSH-TASQPNAPQDPKSAQGSATWEGDKDMDNEEE 1139

  Fly   367 --QLCKICAEN--DKDIRIEPCGHLLCTPCLTSWQVDSEGQG-CPFCRAEIKGTEQ 417
              :.|.||.||  .:::.:.||.|...:.|:..|.:.   || ||.||..:...|:
Mouse  1140 EEEPCVICHENLSPENLSVLPCAHKFHSQCIRPWLMQ---QGTCPTCRLHVLQPEE 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	25/132 (19%)
		Cbl_N2	167..250	CDD:280857	15/86 (17%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	25/180 (14%)
		zf-C3HC4_3	367..415	CDD:290631	16/50 (32%)
		UBA_Cbl_like	834..873	CDD:270503
Dzip3	NP_001103487.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1088..1141		8/53 (15%)
		zf-rbx1	<1143..1184	CDD:289448	14/43 (33%)
		zf-RING_2	1144..1184	CDD:290367	14/42 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910