DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Dtx3l

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001013389.2	Gene:	Dtx3l / 209200	MGIID:	2656973	Length:	748	Species:	Mus musculus

Alignment Length:	486	Identity:	94/486 - (19%)
Similarity:	147/486 - (30%)	Gaps:	170/486 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LSKLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPD----TYQ 81
            :.|:|..:||    |.|..::|.     |..::..|...|     |::||.:....||    ...
Mouse   194 IEKIHHFLSE----QLLEREQKR-----KGSEQKRKCAPQ-----KHTPPDVEREPPDQSSIQVP 244

  Fly    82 RLRLIYSKNEDQMHLLHANEHFNVFIN------NLM-----------------------RKCKQA 117
            .|.|.|.|:.:...|......|.|.|.      |::                       :||.|:
Mouse   245 VLLLEYFKHVNPGRLEFIEYKFGVNIEIQASSPNMVTVGFTSSPFGNVEEASQSFVRDFQKCSQS 309

  Fly   118 IKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRIT----KADAADFW 178
            :      |:.......|.|.         ..:..||...||..:..|....:|    .||.:...
Mouse   310 L------KQDCISLEEHQRA---------KEVRQELSRCFPKLLIKGQGRTLTLLGSPADISAAT 359

  Fly   179 KSNFGNSTLVPWKI---------------FR-------QELNKVHPIIS---GLEAMALKTTI-- 216
            :.......|.|.||               |:       ||::::....:   .::....||.|
Mouse   360 EKVSQGLGLRPVKITASGYTTGIEVDSTRFKLLEPELLQEISEIEQKFNTRGKVQEKGQKTCILF 424

  Fly   217 -------DLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAV---------------------TH 253
                   ||:...:..      ||..||.....||. ::|::                     .|
Mouse   425 VPKDKDLDLSVQSYTG------FTDAFQRATWQLRT-EVLSLKGLGKERARLHNTKFADNFKKEH 482

  Fly   254 PGYVAFLTYDE--VKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEIL---QTIPQNKSLC 313
            |. |.|:|..|  ....|..::.:|..||.:         .:|...:.||.|   |..|...|..
Mouse   483 PN-VHFVTSQESVTLTGLPHHLAQAMQYVSK---------RMGLAPSSGEKLAMDQETPMEISSS 537

  Fly   314 QALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKD 378
            ....|.........|.|.:.:|    |....|||:                    |.||.:...:
Mouse   538 DPHGDQQENAALPAPRGTSSSP----AASKGTEDY--------------------CVICMDTISN 578

  Fly   379 IRIEP-CGHLLCTPCLTSWQVDSEGQGCPFC 408
            ..:.| |.|..||.|::...:..  ..||.|
Mouse   579 KHVLPKCKHEFCTSCISKAMLIK--PVCPVC 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	28/153 (18%)
		Cbl_N2	167..250	CDD:280857	21/120 (18%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	23/121 (19%)
		zf-C3HC4_3	367..415	CDD:290631	12/43 (28%)
		UBA_Cbl_like	834..873	CDD:270503
Dtx3l	NP_001013389.2	RRM1_PAR14	8..86	CDD:240746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..238		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..562		8/37 (22%)
		RING	569..607	CDD:238093	11/39 (28%)
		Deltex_C	616..746	CDD:193607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910