DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Cblb

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_006522010.1	Gene:	Cblb / 208650	MGIID:	2146430	Length:	982	Species:	Mus musculus

Alignment Length:	1005	Identity:	403/1005 - (40%)
Similarity:	517/1005 - (51%)	Gaps:	238/1005 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHL--L 97
            ::.:.|::|:|||||||||||:|||.||:.||||||:||||||||||.||||.||.:|...|  |
Mouse    37 KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQL 101

  Fly    98 HANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVF 162
            ..||:|.::|::||:|.|:||:|||||||:|::|.|..|||||||||:|||||:|:|||||||.|
Mouse   102 SENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQF 166

  Fly   163 AGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNF 227
            .||.|||||||||:||:..||:.|:||||:|||.|::||.|.|||||||||:||||||||:||.|
Mouse   167 QGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVF 231

  Fly   228 EFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWA 292
            |||:||||||||.::||||..||||||||:|||||||||||||:|..|.|||:||||||||||||
Mouse   232 EFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWA 296

  Fly   293 IGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYE 357
            |||||.:|.||||||.||.|.|||:||.||||||||||::|||||:...:....|||.|||||||
Mouse   297 IGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYE 361

  Fly   358 LYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDA 422
            |||||||||||||||||||||::|||||||:||.|||:|| :|:||||||||.||||||.|:||.
Mouse   362 LYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQ-ESDGQGCPFCRCEIKGTEPIIVDP 425

  Fly   423 FDPRKQHNR------NVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRL 481
            ||||.:.:|      ..:.......::||.|:       :..::.|::.......::||.|||..
Mouse   426 FDPRDEGSRCCSIIDPFSIPMLDLDDDDDREE-------SLMMNRLASVRKCTDRQNSPVTSPGS 483

  Fly   482 G----RRSTTPSLMAVQNDLYAGGTPTLSLP--------------SSSCSSIAAASTSSSSSLAS 528
            .    ||...|..:.:         |.||||              .|.|.|...:..||...:..
Mouse   484 SPLAQRRKPQPDPLQI---------PHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRK 539

  Fly   529 ---------------------VATVAASTSSSQH----------QQPQPSAP--PASAVLSN--- 557
                                 ...:......|:|          .||.|...  |..|..:|
Mouse   540 QDKPLPAPPPPLRDPPPPPERPPPIPPDNRLSRHFHHGESVPSRDQPMPLEAWCPRDAFGTNQVM 604

  Fly   558 -----GGGGGGGGGASSSQKNTN-----------------------------------------R 576
                 |.|....|..::|..|..                                         |
Mouse   605 GCRILGDGSPKPGVTANSSLNGRHSRMGSEQVLMRKHRRHDLPSEGAKVFSNGHLATEEYDVPPR 669

  Fly   577 MSAP--------------LIGSCVANSTYG--------QKLPQN--CSHSSTSSSSDNA-----S 612
            :|.|              .:.:|::..|..        .|:|.:  .|.:|..|...|.     |
Mouse   670 LSPPPPVTTLLPSIKCTGPLANCLSEKTRDTVEDDDDEYKIPSSHPVSLNSQPSHCHNVKAPVRS 734

  Fly   613 SSSSYAILQNLHDTGTPATAAAVVAP------------------PLPPRKSSPGVETPSKATAPP 659
            ..:.:.||...|  |.|:.......|                  ||||.:             ||
Mouse   735 CDNGHCILNGTH--GAPSEMKKSNIPDLGIYLKGGGSDSASDPVPLPPAR-------------PP 784

  Fly   660 P---PSSSKSIDNIQCSLD-NVPP------QTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSP 714
            |   |....|::......| .:||      ....|.:||...|:..:|.|........:..::..
Mouse   785 PRDSPKHGSSVNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQ 849

  Fly   715 VLSLLDEDIVEVGP-AETISGVIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGSAAALANGKK 778
            .|.||..|     | .:..||.:...|.........:.:.||..|.||.::|.|..|.|
Mouse   850 DLFLLPSD-----PFFDPTSGQVPLPPARRAAGDSGKANRASQDYDQLPSSSDGSQAPA------ 903

  Fly   779 ANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCG-TVPYENINLEYIARLM 842
                                      .| .:.:|...|....::|..| ....||::.: ||:||
Mouse   904 --------------------------RP-PKPRPRRTAPEIHHRKPHGPEAALENVDAK-IAKLM 940

  Fly   843 NAGYSKENAITALGISRNNIEMAGDILREF 872
            ..||:.|....||.|::||:|:|..|||||
Mouse   941 GEGYAFEEVKRALEIAQNNVEVARSILREF 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	84/122 (69%)
		Cbl_N2	167..250	CDD:280857	60/82 (73%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	76/95 (80%)
		zf-C3HC4_3	367..415	CDD:290631	38/47 (81%)
		UBA_Cbl_like	834..873	CDD:270503	19/39 (49%)
Cblb	XP_006522010.1	Cbl_N	44..165	CDD:367006	83/120 (69%)
		Cbl_N2	171..254	CDD:367171	60/82 (73%)
		SH2_Cbl-b_TKB	248..344	CDD:198176	76/95 (80%)
		RING-HC_Cbl-b	354..419	CDD:319623	55/65 (85%)
		RING-HC finger (C3HC4-type)	373..411	CDD:319623	30/38 (79%)
		UBA_Cbl-b	931..971	CDD:270575	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3464
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I787
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm44192
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4015
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850