DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cbl and Cblb

DIOPT Version :9

Sequence 1:NP_648224.1 Gene:Cbl / 38961 FlyBaseID:FBgn0020224 Length:878 Species:Drosophila melanogaster
Sequence 2:XP_006522010.1 Gene:Cblb / 208650 MGIID:2146430 Length:982 Species:Mus musculus


Alignment Length:1005 Identity:403/1005 - (40%)
Similarity:517/1005 - (51%) Gaps:238/1005 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 QRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHL--L 97
            ::.:.|::|:|||||||||||:|||.||:.||||||:||||||||||.||||.||.:|...|  |
Mouse    37 KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQL 101

  Fly    98 HANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVF 162
            ..||:|.::|::||:|.|:||:|||||||:|::|.|..|||||||||:|||||:|:|||||||.|
Mouse   102 SENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQF 166

  Fly   163 AGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNF 227
            .||.|||||||||:||:..||:.|:||||:|||.|::||.|.|||||||||:||||||||:||.|
Mouse   167 QGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVF 231

  Fly   228 EFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWA 292
            |||:||||||||.::||||..||||||||:|||||||||||||:|..|.|||:||||||||||||
Mouse   232 EFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWA 296

  Fly   293 IGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYE 357
            |||||.:|.||||||.||.|.|||:||.||||||||||::|||||:...:....|||.|||||||
Mouse   297 IGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYE 361

  Fly   358 LYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDA 422
            |||||||||||||||||||||::|||||||:||.|||:|| :|:||||||||.||||||.|:||.
Mouse   362 LYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQ-ESDGQGCPFCRCEIKGTEPIIVDP 425

  Fly   423 FDPRKQHNR------NVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRL 481
            ||||.:.:|      ..:.......::||.|:       :..::.|::.......::||.|||..
Mouse   426 FDPRDEGSRCCSIIDPFSIPMLDLDDDDDREE-------SLMMNRLASVRKCTDRQNSPVTSPGS 483

  Fly   482 G----RRSTTPSLMAVQNDLYAGGTPTLSLP--------------SSSCSSIAAASTSSSSSLAS 528
            .    ||...|..:.:         |.||||              .|.|.|...:..||...:..
Mouse   484 SPLAQRRKPQPDPLQI---------PHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRK 539

  Fly   529 ---------------------VATVAASTSSSQH----------QQPQPSAP--PASAVLSN--- 557
                                 ...:......|:|          .||.|...  |..|..:|   
Mouse   540 QDKPLPAPPPPLRDPPPPPERPPPIPPDNRLSRHFHHGESVPSRDQPMPLEAWCPRDAFGTNQVM 604

  Fly   558 -----GGGGGGGGGASSSQKNTN-----------------------------------------R 576
                 |.|....|..::|..|..                                         |
Mouse   605 GCRILGDGSPKPGVTANSSLNGRHSRMGSEQVLMRKHRRHDLPSEGAKVFSNGHLATEEYDVPPR 669

  Fly   577 MSAP--------------LIGSCVANSTYG--------QKLPQN--CSHSSTSSSSDNA-----S 612
            :|.|              .:.:|::..|..        .|:|.:  .|.:|..|...|.     |
Mouse   670 LSPPPPVTTLLPSIKCTGPLANCLSEKTRDTVEDDDDEYKIPSSHPVSLNSQPSHCHNVKAPVRS 734

  Fly   613 SSSSYAILQNLHDTGTPATAAAVVAP------------------PLPPRKSSPGVETPSKATAPP 659
            ..:.:.||...|  |.|:.......|                  ||||.:             ||
Mouse   735 CDNGHCILNGTH--GAPSEMKKSNIPDLGIYLKGGGSDSASDPVPLPPAR-------------PP 784

  Fly   660 P---PSSSKSIDNIQCSLD-NVPP------QTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSP 714
            |   |....|::......| .:||      ....|.:||...|:..:|.|........:..::..
Mouse   785 PRDSPKHGSSVNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQ 849

  Fly   715 VLSLLDEDIVEVGP-AETISGVIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGSAAALANGKK 778
            .|.||..|     | .:..||.:...|.........:.:.||..|.||.::|.|..|.|      
Mouse   850 DLFLLPSD-----PFFDPTSGQVPLPPARRAAGDSGKANRASQDYDQLPSSSDGSQAPA------ 903

  Fly   779 ANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCG-TVPYENINLEYIARLM 842
                                      .| .:.:|...|....::|..| ....||::.: ||:||
Mouse   904 --------------------------RP-PKPRPRRTAPEIHHRKPHGPEAALENVDAK-IAKLM 940

  Fly   843 NAGYSKENAITALGISRNNIEMAGDILREF 872
            ..||:.|....||.|::||:|:|..|||||
Mouse   941 GEGYAFEEVKRALEIAQNNVEVARSILREF 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CblNP_648224.1 Cbl_N 42..163 CDD:280432 84/122 (69%)
Cbl_N2 167..250 CDD:280857 60/82 (73%)
SH2_Cbl-b_TKB 244..340 CDD:198176 76/95 (80%)
zf-C3HC4_3 367..415 CDD:290631 38/47 (81%)
UBA_Cbl_like 834..873 CDD:270503 19/39 (49%)
CblbXP_006522010.1 Cbl_N 44..165 CDD:367006 83/120 (69%)
Cbl_N2 171..254 CDD:367171 60/82 (73%)
SH2_Cbl-b_TKB 248..344 CDD:198176 76/95 (80%)
RING-HC_Cbl-b 354..419 CDD:319623 55/65 (85%)
RING-HC finger (C3HC4-type) 373..411 CDD:319623 30/38 (79%)
UBA_Cbl-b 931..971 CDD:270575 20/41 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 181 1.000 Domainoid score I3464
eggNOG 1 0.900 - - E1_KOG1785
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 649 1.000 Inparanoid score I787
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001974
OrthoInspector 1 1.000 - - otm44192
orthoMCL 1 0.900 - - OOG6_105001
Panther 1 1.100 - - O PTHR23007
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4015
SonicParanoid 1 1.000 - - X2221
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.850

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