DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cbl and sli-1

DIOPT Version :9

Sequence 1:NP_648224.1 Gene:Cbl / 38961 FlyBaseID:FBgn0020224 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_508145.2 Gene:sli-1 / 180419 WormBaseID:WBGene00004829 Length:582 Species:Caenorhabditis elegans


Alignment Length:666 Identity:269/666 - (40%)
Similarity:358/666 - (53%) Gaps:148/666 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ATRGSGTRVQSQPKIFPSLL--------SKLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLC 58
            :|..|...:...|:..||.:        |::.|..||        .|::.|.|..|.||:|||.|
 Worm    27 STNNSTEALTLSPRAVPSTVSLFEIPSASEMPGFCSE--------EDRRFLLKACKFMDQVVKSC 83

  Fly    59 QQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKE 123
            ..|::|||||||||||||||||..|.||:::|.|   :|..|::..:|:.:::.|||:.||||| 
 Worm    84 HSPRLNLKNSPPFILDILPDTYTHLMLIFTQNND---ILQDNDYLKIFLESMINKCKEIIKLFK- 144

  Fly   124 GKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLV 188
             ...::::.|..||.|||:||.|||||.|:||:||.|::..|:||:||.:|..||..:|....:|
 Worm   145 -TSAIYNDQSEERRKLTKMSLTFSHMLFEIKALFPEGIYIEDRFRMTKKEAESFWSHHFTKKNIV 208

  Fly   189 PWKIFRQELNKVH-PIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVT 252
            ||..|...|.|.| ..|..:||..||.||||:.:|||||||||||||||.|:.||::|||.|...
 Worm   209 PWSTFFTALEKHHGSTIGKMEAAELKATIDLSGDDFISNFEFDVFTRLFYPFKTLIKNWQTLTTA 273

  Fly   253 HPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALL 317
            ||||.|||||||||.||::...|.|||:|||||||.||||||||..:|:|.|||||||||.|||.
 Worm   274 HPGYCAFLTYDEVKKRLEKLTKKPGSYIFRLSCTRPGQWAIGYVAPDGKIYQTIPQNKSLIQALH 338

  Fly   318 DGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIE 382
            :||:||||:||:|:..:.:||..:..|..|.:.||.||||||||||:||:|||||.:|:|:|:||
 Worm   339 EGHKEGFYIYPNGRDQDINLSKLMDVPQADRVQVTSEQYELYCEMGTTFELCKICDDNEKNIKIE 403

  Fly   383 PCGHLLCTPCLTSWQVDSEGQG--CPFCRAEIKGTEQIVVDAFDPRKQHNRNVTNGRQQQQEEDD 445
            |||||||..||.:|| ||:|.|  |||||.|||||.::::|.|.|                    
 Worm   404 PCGHLLCAKCLANWQ-DSDGGGNTCPFCRYEIKGTNRVIIDRFKP-------------------- 447

  Fly   446 TEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRLGRRSTTPSLMAVQNDLYAGGTPTLSLPSS 510
                       :.:......:..||||                .|:::..|:     |..:..|.
 Worm   448 -----------TPVEIEKAKNVAAAEK----------------KLISLVPDV-----PPRTYVSQ 480

  Fly   511 SCSSIAAASTSSSSSLASVATVAASTSSSQHQQPQPSAPPASAVLSNGGGGGGGGGASSSQKNTN 575
            ...|:...:::|..|:..:..|           |.|..|.|...|..         .:|||    
 Worm   481 CSQSLLHDASNSIPSVDELPLV-----------PPPLPPKALGTLDT---------LNSSQ---- 521

  Fly   576 RMSAPLIGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSSSYAILQNLHDTGTPATAAAVV---- 636
                                                 :||||..::.|.:..|...|.|.|    
 Worm   522 -------------------------------------TSSSYVNIKELENVETSGEALAQVVNRQ 549

  Fly   637 ------APPLPPRKSS 646
                  |||||||.|:
 Worm   550 RAPSIQAPPLPPRLSA 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CblNP_648224.1 Cbl_N 42..163 CDD:280432 62/120 (52%)
Cbl_N2 167..250 CDD:280857 45/83 (54%)
SH2_Cbl-b_TKB 244..340 CDD:198176 63/95 (66%)
zf-C3HC4_3 367..415 CDD:290631 33/49 (67%)
UBA_Cbl_like 834..873 CDD:270503
sli-1NP_508145.2 Cbl_N 67..183 CDD:280432 62/120 (52%)
Cbl_N2 187..271 CDD:280857 45/83 (54%)
SH2_Cbl-b_TKB 265..361 CDD:198176 63/95 (66%)
RING 390..434 CDD:238093 29/44 (66%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160162184
Domainoid 1 1.000 133 1.000 Domainoid score I3169
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H134395
Inparanoid 1 1.050 501 1.000 Inparanoid score I747
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001974
OrthoInspector 1 1.000 - - oto20522
orthoMCL 1 0.900 - - OOG6_105001
Panther 1 1.100 - - LDO PTHR23007
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4015
SonicParanoid 1 1.000 - - X2221
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.920

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