DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Cblb

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_006248320.1	Gene:	Cblb / 171136	RGDID:	620535	Length:	982	Species:	Rattus norvegicus

Alignment Length:	1003	Identity:	408/1003 - (40%)
Similarity:	520/1003 - (51%)	Gaps:	234/1003 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHL--L 97
            ::.:.|::|:|||||||||||:|||.||:.||||||:||||||||||.||||.||.:|...|  |
  Rat    37 KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQL 101

  Fly    98 HANEHFNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVF 162
            ..||:|.::|::||:|.|:||:|||||||:|::|.|..|||||||||:|||||:|:|||||||.|
  Rat   102 SENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQF 166

  Fly   163 AGDQFRITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNF 227
            .||.|||||||||:||:..||:.|:||||:|||.|::||.|.|||||||||:||||||||:||.|
  Rat   167 QGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVF 231

  Fly   228 EFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWA 292
            |||:||||||||.::||||..||||||||:|||||||||||||:|..|.|||:||||||||||||
  Rat   232 EFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWA 296

  Fly   293 IGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYE 357
            |||||.:|.||||||.||.|.|||:||.||||||||||::|||||:...:....|||.|||||||
  Rat   297 IGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYE 361

  Fly   358 LYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDA 422
            |||||||||||||||||||||::|||||||:||.|||:|| :|:||||||||.||||||.|:||.
  Rat   362 LYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQ-ESDGQGCPFCRCEIKGTEPIIVDP 425

  Fly   423 FDPRKQHNR------NVTNGRQQQQEEDDTEDIGDFNIATSSLHALSTSSTVAAEKHSPHTSPRL 481
            ||||.:.:|      ..:.......::||.|:       :..::.|::.......::||.|||..
  Rat   426 FDPRDEGSRCCSIIDPFSIPMLDLDDDDDREE-------SLMMNRLASVRKCTDRQNSPVTSPGS 483

  Fly   482 G----RRSTTPSLMAVQNDLYAGGTPTLSLP--------------SSSCSSIAAASTSSSSSLAS 528
            .    ||...|..:.:         |.||||              .|.|.|...:..||...:..
  Rat   484 SPLAQRRKPQPDPLQI---------PHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRK 539

  Fly   529 ---------------------VATVAASTSSSQH----------QQPQPSAP--PASAVLSN--- 557
                                 ...:...:..|:|          .||.|...  |..|..:|
  Rat   540 QDKPLPAPPPPLRDPPPPPERPPPIPPDSRLSRHFHHGEGVPSRDQPMPLEAWCPRDAFGTNQVM 604

  Fly   558 -----GGGGGGGGGASSSQKNTN-----------------------------------------R 576
                 |.|....|..::|..|..                                         |
  Rat   605 GCRILGDGSPKPGVTANSNLNGRHSRMGSDQVLMRKHRRHDLPSEGAKVFSNGHLAPEEYDVPPR 669

  Fly   577 MSAP--------------LIGSCVANSTYG--------QKLPQN--CSHSSTSSSSDNA-----S 612
            :|.|              .|.:|::..|..        .|:|.:  .|.:|..|...|.     |
  Rat   670 LSPPPPVTALLPSIKCTGPIANCLSEKTRDTVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRS 734

  Fly   613 SSSSYAILQNLHDTGTPATAAAVVAP------------------PLPPRKSSPG---------VE 650
            ..:.:.||...|  |||:.......|                  ||||.:..|.         ..
  Rat   735 CDNGHCILNGTH--GTPSEMKKSNIPDLGIYLKGDVSDSASDPVPLPPARPPPRDNLKHGSSVNR 797

  Fly   651 TPSKATAPPPPSSSKSIDNIQCSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSPV 715
            |||......||....:.|.:       ||  :.||.||   |:..:|.|........:..::...
  Rat   798 TPSDYDLLIPPLGEDAFDAL-------PP--SLPPPPP---PARHSLIEHSKPPGSSSRPSSGQD 850

  Fly   716 LSLLDEDIVEVGPAETISGVIDTRPLEARGVTLCRQDSASSHYTQLCTTSSGGSAAALANGKKAN 780
            |.||..|.. ..||   ||.:...|.........:.:.||..|.||.::|.|..|.|
  Rat   851 LFLLPSDPF-FDPA---SGQVPLPPARRAPGDGVKSNRASQDYDQLPSSSDGSQAPA-------- 903

  Fly   781 SAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCG-TVPYENINLEYIARLMNA 844
                                    .| .:.:|...|....::|..| ....||::.: ||:||..
  Rat   904 ------------------------RP-PKPRPRRTAPEIHHRKPHGPEAALENVDAK-IAKLMGE 942

  Fly   845 GYSKENAITALGISRNNIEMAGDILREF 872
            ||:.|....||.|::||:|:|..|||||
  Rat   943 GYAFEEVKRALEIAQNNLEVARSILREF 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	84/122 (69%)
		Cbl_N2	167..250	CDD:280857	60/82 (73%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	76/95 (80%)
		zf-C3HC4_3	367..415	CDD:290631	38/47 (81%)
		UBA_Cbl_like	834..873	CDD:270503	19/39 (49%)
Cblb	XP_006248320.1	Cbl_N	44..167	CDD:280432	84/122 (69%)
		Cbl_N2	171..254	CDD:280857	60/82 (73%)
		SH2_Cbl-b_TKB	248..344	CDD:198176	76/95 (80%)
		RING	373..415	CDD:238093	33/42 (79%)
		UBA_Cbl-b	931..971	CDD:270575	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3380
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	665	1.000	Inparanoid score	I719
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm46285
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	O	PTHR23007
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860