DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cbl and DTX3L

DIOPT Version :9

Sequence 1:NP_648224.1 Gene:Cbl / 38961 FlyBaseID:FBgn0020224 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_612144.1 Gene:DTX3L / 151636 HGNCID:30323 Length:740 Species:Homo sapiens


Alignment Length:494 Identity:98/494 - (19%)
Similarity:160/494 - (32%) Gaps:198/494 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 ANEHF-NVFINN---LMRKC------KQAIKLFKEGKEKMFDENSHYRRNLTK-----LSLV--- 145
            |.|.| :.|..|   |.::|      |||.| ||:      :.|..:.:.|.|     |:|:   
Human   290 ARESFASEFQKNTEPLKQECVSLADSKQANK-FKQ------ELNHQFTKLLIKEKGGELTLLGTQ 347

  Fly   146 -----FSHMLSELKAIFPNGVFAGD-QFRITKADAADFWKSNFGNSTLVPWKIFRQ--ELNKVHP 202
                 ....:||.....|..:||.: ...:.:.|:|.:        .|:..::.::  |:.|.:.
Human   348 DDISAAKQKISEAFVKIPVKLFAANYMMNVIEVDSAHY--------KLLETELLQEISEIEKRYD 404

  Fly   203 IISGLEAMALKTTI---------DLTCN---DFISNFEF-------------------------- 229
            |.|.:.....||.|         ||:.:   .||..|:.                          
Human   405 ICSKVSEKGQKTCILFESKDRQVDLSVHAYASFIDAFQHASCQLMREVLLLKSLGKERKHLHQTK 469

  Fly   230 --DVFTRLFQPWVTLLRNWQILAVTH-PGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQW 291
              |.| |...|.|..:.|.:.:.:|. |.::         |:.::|:||.|              
Human   470 FADDF-RKRHPNVHFVLNQESMTLTGLPNHL---------AKAKQYVLKGG-------------- 510

  Fly   292 AIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYL-YPDGQAYNPDLSSAVQSPTEDHITVTQEQ 355
              |..:..|:.|:             :||.....: ..|.:|.:|.|..:|.|          |.
Human   511 --GMSSLAGKKLK-------------EGHETPMDIDSDDSKAASPPLKGSVSS----------EA 550

  Fly   356 YEL-YCEMGSTFQLCKICAENDKDIRIEP-CGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQI 418
            .|| ..|.|    :|.||.:...:.::.| |.|..|.||:.  :..|....||.|          
Human   551 SELDKKEKG----ICVICMDTISNKKVLPKCKHEFCAPCIN--KAMSYKPICPTC---------- 599

  Fly   419 VVDAFDPRKQHNRNVTNGRQQQQEEDDTEDIGD--FNIATSSLHALSTSSTVA----------AE 471
                     |.:..:..|.|.:         |.  |.::..||....:..|:.          .|
Human   600 ---------QTSYGIQKGNQPE---------GSMVFTVSRDSLPGYESFGTIVITYSMKAGIQTE 646

  Fly   472 KHSPHTSPRLGRRSTTPSLMAVQNDLYAGGTPTLSLPSS 510
            :|     |..|:|             |.|...|..||.:
Human   647 EH-----PNPGKR-------------YPGIQRTAYLPDN 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CblNP_648224.1 Cbl_N 42..163 CDD:280432 21/86 (24%)
Cbl_N2 167..250 CDD:280857 21/124 (17%)
SH2_Cbl-b_TKB 244..340 CDD:198176 17/97 (18%)
zf-C3HC4_3 367..415 CDD:290631 13/48 (27%)
UBA_Cbl_like 834..873 CDD:270503
DTX3LNP_612144.1 RRM1_PAR14 8..86 CDD:240746
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..119
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..231
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..551 8/36 (22%)
RING-HC_DTX3L 560..600 CDD:319626 13/60 (22%)
RING-HC finger (C3HC4-type) 561..599 CDD:319626 12/39 (31%)
Deltex_C 608..738 CDD:193607 17/87 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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