DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and AgaP_AGAP000928

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_003437137.1	Gene:	AgaP_AGAP000928 / 1270411	VectorBaseID:	AGAP000928	Length:	335	Species:	Anopheles gambiae

Alignment Length:	417	Identity:	87/417 - (20%)
Similarity:	153/417 - (36%)	Gaps:	94/417 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LSKLHGAISEACVSQRLSTDKKTLEKTWKLMDKVVKLCQQPKMNLKNS-PPFILDILPDTYQRLR 84
            :|..|....:|.:.:.:..|::.:|.....:.:|:.|..|......|: ...:.::|...|..|.
Mosquito     1 MSLFHANAGQAEIIRTVQKDQEHIEYVRAALSEVLLLLSQRHWFRYNALCKLVAEVLYHHYAILH 65

  Fly    85 LIYSKNEDQMHLLHANEHFNVFINNLMRKCKQAIKLFKE-GKEKMFDENSHYRRNLTKLSLVFSH 148
            .:.:..|:...::..:.::.:..|    |..|.:.:..| |.|.:.|      |.||.|......
Mosquito    66 NLQTLGEEYTGIIQVDANYVMLPN----KALQLLAILLEYGGEHVVD------RVLTYLQTEIDR 120

  Fly   149 MLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPW-KIFRQELNKVHPIISGLEAMAL 212
            ....|:::........|..|:                 :||: :.|...|..:|   .|...::.
Mosquito   121 SEELLESVKTGLHKLIDTLRV-----------------VVPYVRGFHTSLFYIH---GGKYHISK 165

  Fly   213 KTTIDLTCNDFISNFEFD---VFTRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYIL 274
            :    ||..:::|.|..|   :|.|:..|.:..|   .:|.|| ||....:          |..|
Mosquito   166 R----LTGINYVSFFLRDLACLFYRVLPPALLCL---FLLPVT-PGLQVLI----------RNWL 212

  Fly   275 KAGSYVFRLSCTRLGQWAIGYVTAEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQA--YNPDL 337
            |....|:       |..|:||||....:|           ||...:::  |.....||  ..|.:
Mosquito   213 KEDHSVY-------GYKALGYVTLTQLVL-----------ALAARYQQ--YRSQPSQAKVVAPSV 257

  Fly   338 SSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEG 402
            .||.:|.|.......:.              |.:|.:..:.|.:..||||.|..|:..|.  .:.
Mosquito   258 RSAERSRTASGTLPGRN--------------CALCMDTAQAITVTQCGHLFCWQCILHWL--DQR 306

  Fly   403 QGCPFCRAEIKGTEQIVVDAF--DPRK 427
            |.||.||..:|.|..:.:..|  :|.:
Mosquito   307 QVCPICRESVKKTRVVRLQNFSVEPER 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	21/122 (17%)
		Cbl_N2	167..250	CDD:280857	16/86 (19%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	22/97 (23%)
		zf-C3HC4_3	367..415	CDD:290631	16/47 (34%)
		UBA_Cbl_like	834..873	CDD:270503
AgaP_AGAP000928	XP_003437137.1	Pex2_Pex12	20..246	CDD:282595	58/293 (20%)
AgaP_AGAP000928	XP_003437137.1	RING	275..316	CDD:238093	15/42 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910