DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and AgaP_AGAP006900

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_308856.3	Gene:	AgaP_AGAP006900 / 1270179	VectorBaseID:	AGAP006900	Length:	899	Species:	Anopheles gambiae

Alignment Length:	201	Identity:	37/201 - (18%)
Similarity:	57/201 - (28%)	Gaps:	87/201 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 IPQNKSLCQAL---LDGHREG---FYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGS 364
            |||..:..::|   |||..:.   ....|...|.||.|...                       |
Mosquito   447 IPQASARLKSLLERLDGELQSARWLDTTPVRLAVNPSLIEP-----------------------S 488

  Fly   365 TFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFC--------RAEIKGT------ 415
            .|. |.:|........:.||||..|..||.  :.......||.|        |:.:.|:
Mosquito   489 DFD-CVLCCRTLWRPVVTPCGHTYCWVCLD--RCMDYSSSCPLCMAPLVEQFRSHLPGSAATPPE 550

  Fly   416 -----------------------------EQIVVDAFDPRKQHNRNVTNGRQQQQEEDDTEDIGD 451
                                         ::.:.:|::            |:||||:|....:..
Mosquito   551 AAAAGPASPSTNLISLAKRKMTRFVDLAMQRFIPEAYE------------RRQQQEQDREPTVPV 603

  Fly   452 FNIATS 457
            |...|:
Mosquito   604 FICTTA 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	12/39 (31%)
		zf-C3HC4_3	367..415	CDD:290631	13/55 (24%)
		UBA_Cbl_like	834..873	CDD:270503
AgaP_AGAP006900	XP_308856.3	RING	41..>67	CDD:302633
		TPR_11	161..227	CDD:290150
		TPR repeat	162..190	CDD:276809
		TPR repeat	195..225	CDD:276809
		RING	491..533	CDD:238093	12/44 (27%)
		LON_substr_bdg	600..805	CDD:280370	2/10 (20%)
		LON	600..805	CDD:271862	2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910