DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbl and Cbl

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_031645.2	Gene:	Cbl / 12402	MGIID:	88279	Length:	913	Species:	Mus musculus

Alignment Length:	944	Identity:	413/944 - (43%)
Similarity:	520/944 - (55%)	Gaps:	188/944 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEH 102
            :.|||.:||.||||||||:|||.||:.||||||:|||:||||||.||.:.|:.|.:|..|..||:
Mouse    48 TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEY 112

  Fly   103 FNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQF 167
            |.||:.|||:|.||.|.|||||||:|::|||..|||||||||:|||||:|||.|||:|:|.||.|
Mouse   113 FRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTF 177

  Fly   168 RITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVF 232
            ||||||||:||:..||..|:||||.|||.|::||||.|||||||||:||||||||:||.||||:|
Mouse   178 RITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIF 242

  Fly   233 TRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVT 297
            |||||||.:|||||..||||||||:|||||||||||||::|.|.|||:|||||||||||||||||
Mouse   243 TRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVT 307

  Fly   298 AEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEM 362
            |:|.||||||.||.|.|||:||.||||||:|||:..||||:...:...:|||.||||||||||||
Mouse   308 ADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEM 372

  Fly   363 GSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRK 427
            ||||||||||||||||::|||||||:||.|||||| :||||||||||.||||||.||||.||||.
Mouse   373 GSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQ-ESEGQGCPFCRCEIKGTEPIVVDPFDPRG 436

  Fly   428 QHN--RNVTNGRQQQQEEDDTEDIGDFN------IATSSLHALSTSSTVAAEKHSPHTSPRLGRR 484
            ..:  |....|......:||.::..|.:      :|.:.:...|:..::|.:...|...|||
Mouse   437 SGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRL--- 498

  Fly   485 STTPSLMAVQNDLYAGGTPTLSLPSSSCSSIAAASTSSSSSLAS--------------------- 528
                       ||.....|   :|:|: |.:..||.::|.||..
Mouse   499 -----------DLLQQRAP---VPAST-SVLGTASKAASGSLHKDKPLPIPPTLRDLPPPPPPDR 548

  Fly   529 VATVAAST--------------SSSQHQQPQPSAPPASAVLS-----------NGGGGGGGGGAS 568
            ..:|.|.|              .|.....|.||:.|..:.||           |.|....|
Mouse   549 PYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNG---- 609

  Fly   569 SSQKNTNRMSAPL--------------IGSCVANSTYGQKLPQNCSHSSTSSSSDNASSSSSYAI 619
              ::.|||.|.|.              :||..:..|           |.|.:||..|...|.
Mouse   610 --RELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDT-----------SMTMNSSPVAGPESE--- 658

  Fly   620 LQNLHDTGTPATAA----AVVAPPLPPRKSSPGVE----------TP-SKATAPPPPSSSKSIDN 669
                |....|:::|    ::.|.|||..|..||.:          || |:......|...:.::.
Mouse   659 ----HPKIKPSSSANAIYSLAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRPLEA 719

  Fly   670 IQ----CSLDNVPPQTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTS--PVLSLLDEDIVEVGP 728
            .|    |..|......|...:....|.::.........:..:||:.||  |..|..::|..:| |
Mouse   720 TQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSASGEGNLATAHTSTGPEESENEDDGYDV-P 783

  Fly   729 AETISGVIDTRPLEARGVTLCRQDSASSHYTQLC-----TTSSGGSAA----------ALANGKK 778
            ...:..|:..|       ||....:|||.:..|.     |..:.||..          .:.:.:|
Mouse   784 KPPVPAVLARR-------TLSDISNASSSFGWLSLDGDPTNFNEGSQVPERPPKPFPRRINSERK 841

  Fly   779 ANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCGTVPYENINLEYIARLMN 843
            |:|.:|....|              :||                  ..|.|...::.| |.|||:
Mouse   842 ASSYQQGGGAT--------------ANP------------------VATAPSPQLSSE-IERLMS 873

  Fly   844 AGYSKENAITALGISRNNIEMAGDILREFVSKNS 877
            .|||.::...||.|:.||||||.:|||||||.:|
Mouse   874 QGYSYQDIQKALVIAHNNIEMAKNILREFVSISS 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	81/120 (68%)
		Cbl_N2	167..250	CDD:280857	62/82 (76%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	75/95 (79%)
		zf-C3HC4_3	367..415	CDD:290631	40/47 (85%)
		UBA_Cbl_like	834..873	CDD:270503	21/38 (55%)
Cbl	NP_031645.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269\|PubMed:18034775	1..355		220/306 (72%)
		4H	45..173		83/124 (67%)
		Cbl_N	52..173	CDD:280432	81/120 (68%)
		EF-hand-like	174..246		54/71 (76%)
		Cbl_N2	177..260	CDD:280857	62/82 (76%)
		SH2-like	247..349		80/101 (79%)
		SH2_Cbl-b_TKB	254..350	CDD:198176	75/95 (79%)
		Linker	350..378		19/27 (70%)
		Required for ubiquitination of SPRED2. /evidence=ECO:0000250\|UniProtKB:P22681	356..913		193/636 (30%)
		RING	379..421	CDD:238093	35/41 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..460		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..613		37/196 (19%)
		Interaction with CD2AP. /evidence=ECO:0000250	646..913		70/274 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..727		21/96 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..787		9/51 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	814..863		12/48 (25%)
		UBA_c-Cbl	864..903	CDD:270576	17/24 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3464
eggNOG	1	0.900	-	-		E1_KOG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I787
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001974
OrthoInspector	1	1.000	-	-		otm44192
orthoMCL	1	0.900	-	-		OOG6_105001
Panther	1	1.100	-	-	LDO	PTHR23007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4015
SonicParanoid	1	1.000	-	-		X2221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850