DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and cox15

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_002937233.1	Gene:	cox15 / 100486044	XenbaseID:	XB-GENE-989603	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	435	Identity:	94/435 - (21%)
Similarity:	146/435 - (33%)	Gaps:	134/435 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 NSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKADAADFWKSNFGNSTLVPWKIFRQE 196
            ||...|.:.:..||.|.|::       ..|..|...|:|::           ..::|.|.:.::
Frog    63 NSSAERIMGRWLLVCSGMVA-------GAVILGGVTRLTES-----------GLSMVDWHLIKE- 108

  Fly   197 LNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVFTRLFQPWVTLLRNWQILAVTHPGYVAFLT 261
               :.|..:..|..|                ||:.:.:.  |...:|.:...|     ....|:.
Frog   109 ---MKPPATQEEWQA----------------EFEKYQQF--PEFKILNHEMTL-----NEFKFIW 147

  Fly   262 YDEVKARL------QRYILKAGSYVFRLSCTRLGQWAIGYVT--AEGEILQTIPQNKSLC----- 313
            :.|...|:      ..|||.|..:           |..|:.:  .:|.:|       .||
Frog   148 FMEYSHRMWGRAVGLAYILPAVYF-----------WRKGWFSRGMKGRVL-------GLCGFVCF 194

  Fly   314 QALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKD 378
            |.||     |:|:          :.|.::...|.:......||.|...:||...|  .||.....
Frog   195 QGLL-----GWYM----------VKSGLEEKPESYDIPRVSQYRLAAHLGSAIVL--YCASLWTG 242

  Fly   379 I-------RIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRKQHNRNVTNG 436
            :       ::.....||.....|.|..     |..|..| :.|.....:||        ..|.|.
Frog   243 LSLLLPKHKLPETRQLLQLRRFTHWTT-----GLVFLTA-LSGAFVAGLDA--------GLVYNS 293

  Fly   437 RQQQQEEDDTEDIGDF---------NIATSSL-HALSTSSTVAAEKHSPHTSPR--LGRRS--TT 487
            ..:..|:...:|:..|         |..|... |.:...|:|||.....:.|.|  |.||:  ..
Frog   294 FPKMGEKWIPDDLLAFSPTFKNFFENATTVQFDHRILGISSVAAITGLYYFSRRVPLPRRAKLAL 358

  Fly   488 PSLMAVQNDLYAGGTPTLSL--PSSSCSSIAAASTSSSSSLASVA 530
            .||:||.......|..||.|  |    :|:|||..|.|.:|.|:|
Frog   359 NSLIAVAYLQVTLGISTLLLYVP----TSLAAAHQSGSLALLSMA 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432	8/30 (27%)
		Cbl_N2	167..250	CDD:280857	11/82 (13%)
		SH2_Cbl-b_TKB	244..340	CDD:198176	19/108 (18%)
		zf-C3HC4_3	367..415	CDD:290631	10/54 (19%)
		UBA_Cbl_like	834..873	CDD:270503
cox15	XP_002937233.1	COX15-CtaA	11..408	CDD:388555	94/435 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910