DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and mib1

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001123407.1	Gene:	mib1 / 100170182	XenbaseID:	XB-GENE-1001395	Length:	1010	Species:	Xenopus tropicalis

Alignment Length:	217	Identity:	46/217 - (21%)
Similarity:	75/217 - (34%)	Gaps:	79/217 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 YVTAEGEILQTIPQNK-----------SLCQALLDGHREGFYLYPDGQ--AYNPDLSS------- 339
            ::.|.|..| ||...|           :||:||...|:|    ...||  :::|.:.|
Frog   758 FLAANGADL-TIRNKKGQSPLDLCPDPNLCKALAKCHKE----KSSGQVGSHSPSMISNDSETLE 817

  Fly   340 -----------------------AVQSPTEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRI 381
                                   ::.||......:.:||    .:..:..:.|.:|::....:..
Frog   818 ECMVCSDLKRDTLFGPCGHIATCSLCSPRVKKCLICKEQ----VQSRTKIEECVVCSDKKAAVLF 878

  Fly   382 EPCGHL-LCTPCLTSWQVDSEGQGCPFCRAEI------------KGTEQIV-------VDAFDPR 426
            :||||: .|..|.      |..:.|..|||.:            ||||.:.       :.|....
Frog   879 QPCGHMCACENCA------SLMKKCVQCRAVVERRVPFVMCCSGKGTEDVTDDIAGGNIQALQKD 937

  Fly   427 KQH-NRNVTNGRQQQQEEDDTE 447
            |.: |.|....:.|||.:|..|
Frog   938 KDNTNVNADVQKLQQQLQDIKE 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	16/87 (18%)
		zf-C3HC4_3	367..415	CDD:290631	14/60 (23%)
		UBA_Cbl_like	834..873	CDD:270503
mib1	NP_001123407.1	MIB_HERC2	15..71	CDD:369043
		ZZ_Mind_bomb	83..127	CDD:239079
		MIB_HERC2	154..218	CDD:369043
		SH3_15	248..311	CDD:375773
		SH3_15	333..397	CDD:375773
		PHA03095	439..>710	CDD:222980
		ANK repeat	464..527	CDD:293786
		ANK repeat	529..560	CDD:293786
		ANK repeat	562..593	CDD:293786
		ANK repeat	595..629	CDD:293786
		ANK repeat	631..663	CDD:293786
		ANK repeat	665..696	CDD:293786
		Ank_2	670..770	CDD:372319	5/12 (42%)
		RING1-HC_MIB1	818..854	CDD:319638	2/35 (6%)
		RING-HC finger (C3HC4-type)	819..853	CDD:319638	2/33 (6%)
		RING2-HC_MIB1	865..901	CDD:319639	10/41 (24%)
		RING-HC finger (C3HC4-type)	866..900	CDD:319639	10/39 (26%)
		RING3-HC_MIB1	962..1003	CDD:319641
		RING-HC finger (C3HC4-type)	963..995	CDD:319641
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910