DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbl and neurl3

DIOPT Version :9

Sequence 1:	NP_648224.1	Gene:	Cbl / 38961	FlyBaseID:	FBgn0020224	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_002932612.2	Gene:	neurl3 / 100145805	XenbaseID:	XB-GENE-5797365	Length:	315	Species:	Xenopus tropicalis

Alignment Length:	171	Identity:	36/171 - (21%)
Similarity:	66/171 - (38%)	Gaps:	44/171 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 RLSCTRLGQ----------------WAIGYVTAEGEILQTI--PQNKS-------LCQALLDGHR 321
            ::.|.|.|:                ||:..|..:.:.:|.:  |..|:       .||:.::...
Frog   144 KVFCQREGEPCARVLFSGIPKNTKLWAMLDVYGKTKAIQVMGGPSQKNPTPPCQCQCQSQINKDP 208

  Fly   322 EGFYLYPDGQAYN-PDLSSAVQSPTED----HITVT---QEQYELYCEMGSTFQLCKICAENDKD 378
            :     |.|..:: .:::.....||.:    :.|.|   |:.:.::.|...:   |.||.:...:
Frog   209 Q-----PLGSGHSLEEIAEQTAIPTANLNSCNDTTTWHSQKNFHIFLEDDPS---CVICQDRKAN 265

  Fly   379 IRIEPCGH-LLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQI 418
            ..:.|||| ..|..|:...|  ...|.||.||..|...:.|
Frog   266 TLLLPCGHCTFCQSCVEKLQ--GHSQSCPLCRQRIHSAQYI 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbl	NP_648224.1	Cbl_N	42..163	CDD:280432
		Cbl_N2	167..250	CDD:280857
		SH2_Cbl-b_TKB	244..340	CDD:198176	13/83 (16%)
		zf-C3HC4_3	367..415	CDD:290631	16/48 (33%)
		UBA_Cbl_like	834..873	CDD:270503
neurl3	XP_002932612.2	NEUZ	30..146	CDD:128856	0/1 (0%)
		SPRY	31..181	CDD:295394	6/36 (17%)
		Neuralized	32..97	CDD:284568
		zf-C3HC4_3	252..300	CDD:290631	16/52 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910