DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exo70 and EXOC7

DIOPT Version :9

Sequence 1:	NP_648222.3	Gene:	Exo70 / 38959	FlyBaseID:	FBgn0266667	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	XP_024306436.1	Gene:	EXOC7 / 23265	HGNCID:	23214	Length:	763	Species:	Homo sapiens

Alignment Length:	597	Identity:	197/597 - (32%)
Similarity:	321/597 - (53%)	Gaps:	42/597 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QAHNKLEKEATNLALLKDRVDKYHDLSTQMSSILTIFEKRLGNLEQTILPVYQETEQLQKRQQNL 73
            :..:||::|...|:.::|.::|...|:..|.|||:.||.||..||.:|:||:::||.||:.|:|:
Human    13 EIEDKLKQEEETLSFIRDSLEKSDQLTKNMVSILSSFESRLMKLENSIIPVHKQTENLQRLQENV 77

  Fly    74 EATLNCLESVLSHYDVSQEVCQLIHQGPVEGNISVFLDALAKLRDANDYFRHNNSQSVELENVTS 138
            |.||:||:.|:|:|.|:.:..::|.:||. |.:..:|.::||::.|.:||:.|:..|.||..|..
Human    78 EKTLSCLDHVISYYHVASDTEKIIREGPT-GRLEEYLGSMAKIQKAVEYFQDNSPDSPELNKVKL 141

  Fly   139 LFNTGCEGLSQHYSMLLKKHSAPLKPVELLDLIYIEDD-SSDEYTSFRQLSQTTREELYTISHWL 202
            ||..|.|.|...:..|:.:||..:.||.:||||..:|| .:.|..:...|.::..:::..||.||
Human   142 LFERGKEALESEFRSLMTRHSKVVSPVLILDLISGDDDLEAQEDVTLEHLPESVLQDVIRISRWL 206

  Fly   203 EQNLR--EYTNIYATERGEVVLRSLQLLKDH-QKSNSWGHEALRPR-HSGRQTEPKKTTSARLQQ 263
            .:..|  ::.|:|...|...:.||::.||:| .||:|.......|. .:.|:..|.|....|...
Human   207 VEYGRNQDFMNVYYQIRSSQLDRSIKGLKEHFHKSSSSSGVPYSPAIPNKRKDTPTKKPVKRPGT 271

  Fly   264 IFEKKANKLYLRATQTIEQSTGFSIKKASSHSDHLTSEDLMDGDQELDKYLVMLLGLQRLLNWER 328
            |  :||..|..:.:|     .|...||..|:...|...|.| .|.|.|.|:..:....:|...|.
Human   272 I--RKAQNLLKQYSQ-----HGLDGKKGGSNLIPLEGRDDM-LDVETDAYIHCVSAFVKLAQSEY 328

  Fly   329 AIMIDIIPQSKHNEVFATLAYNAIDLVVKDAEAITQRILRCISRKEWTSALGIFSALKRVILLQP 393
            .::.||||:....:.|.:|..:|:|.::.:.|.|.....:.|.|.::::.|.:|..|:.:...:|
Human   329 QLLADIIPEHHQKKTFDSLIQDALDGLMLEGENIVSAARKAIVRHDFSTVLTVFPILRHLKQTKP 393

  Fly   394 DIDRTYD---PAQREQLKKVLKKLQHTGAKALEHFLDVVKGESSTNIVGQSNVPKDATVHELTSN 455
            :.|:...   .:.:.:|..::..::..||||||.|.|.:|.:...    :.|:|||.||||||||
Human   394 EFDQVLQGTAASTKNKLPGLITSMETIGAKALEDFADNIKNDPDK----EYNMPKDGTVHELTSN 454

  Fly   456 TIWFIEHLYDHFDVIGSILAQDVL---YSTQLDTILMKKALPVE----------ERNKALLAIYI 507
            .|.|::.|.|..:..|::||..||   |:..||        |.|          |.:|.||:.||
Human   455 AILFLQQLLDFQETAGAMLASQVLGDTYNIPLD--------PRETSSSATSYSSEFSKRLLSTYI 511

  Fly   508 KKALAELNLSIMNKCEQYNDQATKHLFRLNNIHYILKSLQRSNLIDLVTLAEPECEHSYMEMIRE 572
            .|.|..|.|::::|.:.|.|.|...:|..||.:||||||::|.||.||.:.:...|.||.|.|.:
Human   512 CKVLGNLQLNLLSKSKVYEDPALSAIFLHNNYNYILKSLEKSELIQLVAVTQKTAERSYREHIEQ 576

  Fly   573 LKASYQKTWSKM 584
            ...:||::|.|:
Human   577 QIQTYQRSWLKV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exo70	NP_648222.3	Exo70	315..686	CDD:397277	92/286 (32%)
EXOC7	XP_024306436.1	Exo70	319..>610	CDD:308612	92/282 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145447
Domainoid	1	1.000	207	1.000	Domainoid score	I2902
eggNOG	1	0.900	-	-		E1_KOG2344
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41019
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2321
Isobase	1	0.950	-	0	Normalized mean entropy	S4857
OMA	1	1.010	-	-		QHG56212
OrthoDB	1	1.010	-	-		D186707at33208
OrthoFinder	1	1.000	-	-		FOG0000506
OrthoInspector	1	1.000	-	-		oto91289
orthoMCL	1	0.900	-	-		OOG6_102697
Panther	1	1.100	-	-	LDO	PTHR12542
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3620
SonicParanoid	1	1.000	-	-		X7127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750