Protein Alignment Oseg1 and Ift122

DIOPT Version :10

• Sequence 1: NP_648221.3
• Gene: Oseg1 / 38957
• FlyBaseID: FBgn0265102
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_006506860.1
• Gene: Ift122 / 81896
• MGIID: 1932386
• Length: 1242
• Species: Mus musculus
• Alignment Length: 1252
• Identity: 553/1252 - (44%)
• Similarity: 798/1252 - (63%)
• Gaps: 113/1252 - (9%)

  Fly     1 MRGVLKWLERIEFPNSKDNEISVHNVCYAPDGSQLVVAAGDRLLIYDPNDGSLLNTLKAHKDTVN 65
            ||.||.|.::.        |..::::.:.|||:||::|||:|||:||.:||:||..||.|||||.
Mouse     1 MRAVLTWRDKA--------EQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGTLLQPLKGHKDTVY 57

  Fly    66 CVAYSRDGKRFASGASDKMVIVWSPQLEGLLKYSHGDSIQCMSFNPVSHHLASCSLSDFAFWSAD 130
            ||||::||||||||::||.:|:|:.:|||:|||:|.|||||:|:|||:|.|||||.|||..||.:
Mouse    58 CVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPE 122

  Fly   131 QKAVQKYKISARVNGCSWTNDGQYLILGLANGTISIRNKLGEEKGRIDRPGGPNSNVFSVQCCPA 195
            ||:|.|:|.|:::..||||||||||.||:|||.||||||.||||.:|:||||..|.::|:...|:
Mouse   123 QKSVSKHKSSSKITCCSWTNDGQYLALGMANGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPS 187

  Fly   196 S------------------------------------GPGSV----------------------D 202
            |                                    ..||.                      |
Mouse   188 SRWETIWMSRENEDAEDVIVNKYVQEIPSILKSTVYNSQGSEAEEEEQEEEDDSPRDGNSEEHND 252

  Fly   203 TIGVVDWSQTLSFHTLSGQMIGKERTLGFDPLCLQYFPNGEFCLVGGCTGGLHFFTREGIRLGTL 267
            .:.|.||.|.|||:.|||:.|||:|.|.|||.|:.||..||:.||||....:..||::|:||||:
Mouse   253 ILAVADWGQKLSFYQLSGKQIGKDRPLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTV 317

  Fly   268 GDTFDTWIWTVALHPNGQSYTIGCQDGTLACFNIASSTVHALYRERYAFRENMCDVIIQHLISGQ 332
            |:. ::|:||..:.|:.....:||||||::.:.:..||||.||::|||:|::|.|||:||||:.|
Mouse   318 GEQ-NSWVWTCRVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQ 381

  Fly   333 KVRIKCRDLVQKIAIYRNRLAVQLPERVVLYELSSGEDQPMHYKVREKIQQKFDCSLLVVCGRHI 397
            |||||||:||:|||||:||||:||||::::|||.|.:...|||:|:|||.:||:|:|||||..||
Mouse   382 KVRIKCRELVKKIAIYKNRLAIQLPEKILIYELYSEDSTDMHYRVKEKIVKKFECNLLVVCADHI 446

  Fly   398 VLCQEKRLQCLDFMGVLQREWIMDSFIRYIKVTGGPVGREGLMVGLKNGQVFRIFLNNSLPLLIT 462
            :||||||||||.|.||.:|||.|:|.||||||.|||.|||||:|||||||:.:||::|...:::.
Mouse   447 ILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIVLL 511

  Fly   463 TAVSAVRCLDINSKRSKIAVVDDVGRLVVRDVINDTILYQDTGVNSVTWNTHLDSMLCYTHTTGG 527
            ...:||||||:::.|:|:||||:....:|.|:....:|:|:...|||.|||..:.|||:   :||
Mouse   512 KQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCF---SGG 573

  Fly   528 --LSVRVGNLPPRAPQNMHGVVVGLCGATAFCLRGNIMHNTPLALGSTMWQFIEAGLFDEAYQVA 590
              |:::....|.. .|.:.|.|||..|:..|||....|....:...:.|:|:::..:|.||||:|
Mouse   574 GYLNIKASTFPVH-QQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFKEAYQIA 637

  Fly   591 CLGVTTSDWEGLAQSALEALHINIARDAYVKVRNLPWLKLIGELRDQQQRSAVPKEVLLAENCAF 655
            |||||.:||..||..|||.|....||.|:.:|::|.:|:||..:.::::|.....::.||:..::
Mouse   638 CLGVTDADWRELAMEALEGLEFETARKAFTRVQDLRYLELISSIEERKKRGETNNDLFLADVFSY 702

  Fly   656 AGKFKEAARLFLKCGQSSRALEMYTDLRMFDLAQEYIKDGTDQEKKELVRKRAEWAYSVKEPRAA 720
            .|||.|||:|:.:.|..:.||:|||||.||:.|::::..|..:|.|.|:.|:|:||.::.||:||
Mouse   703 QGKFHEAAKLYKRSGHENLALDMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNINEPKAA 767

  Fly   721 AELLLSAGENQKAIDIVAEQGWADVLYDIGRRLSLTERDSLESVAQNLKTLKALPLAAEIFKKLG 785
            .|:.:||||:.|||:|....||.|:|.||.|:|...||:.|...|...|.|.:...|||.:.|:|
Mouse   768 VEMYISAGEHAKAIEISGSHGWVDMLIDIARKLDKAEREPLLMCACYFKKLDSPGYAAETYLKIG 832

  Fly   786 DEAQVVQLHIEVRDWPEAFRLAESLPELLPTVHYQHGQWLAETDQFIEAHQAYIKAGRTKEANRL 850
            |...:|||:::.:.|.|||.|.|..||....|:..:.|||||.|:|.||.:|:.||||..||.|:
Mouse   833 DLKSLVQLYVDTKRWDEAFALGEKHPEFKDDVYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRV 897

  Fly   851 LKQLSNTAIVEERYLDASYFYWLLAKQHLDVYHAKEEQNPVDHHLTEYKNHLRVAKVYYAYSVIY 915
            |:||::.|:||.|:.||:|:||:|:.|.||:..|...|.  |..|.::.:...:|::|:.|..|:
Mouse   898 LEQLTHNAVVESRFNDAAYYYWMLSMQCLDMAQADPAQK--DAMLDKFHHFQHLAELYHGYQTIH 960

  Fly   916 SYMKEPFTTHSPVSLFNVSRFILNEVEHKGVPKGVSMFSVLFTLAKQAKFLQANKLCLLINKRLQ 980
            .|.:|||:...|.:|||:|:|:|:.:. |..|.|:|..:.|||||||:|.|.|.||......:|:
Mouse   961 RYTEEPFSFDLPETLFNISKFLLHSLT-KATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLR 1024

  Fly   981 SLKPPAGVQEQIDLNFLNSKACKSGFNDPEELLPLCYKCSNYSQHLNS--NCCPTCRQDYIFSFV 1043
            .|:.||.:|:.|:|..|..::  ..|:|.|||:||||:||..:..||:  |.|..|||.:|||..
Mouse  1025 GLQIPARIQKSIELGTLTIRS--KPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSAS 1087

  Fly  1044 SFEILPLVQFYPEVDISDAEAERL--LLAPAKHAE------------------------DSDP-- 1080
            |:|:|.||:||.|..|:|.||..|  |.||....|                        :.||
Mouse  1088 SYEVLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWRETSSNNSQTLKLDETMDSIGEDDPFT 1152

  Fly  1081 ----FNEDVASALPLSLDRNGLRAIDPNHVLILKRRGKNVRNVYYRNILPDLQVTYCPQCLLLFY 1141
                |.:..:..:|:.::|:.||::....||| ||....::..|:|::|||..:|.||.|..:|:
Mouse  1153 AKLSFEQGSSEFVPVVVNRSVLRSMSRRDVLI-KRWPPPLQWQYFRSLLPDASITMCPSCFQMFH 1216

  Fly  1142 AEDFELQVLQKGHCPFC 1158
            :||:||.|||...||:|
Mouse  1217 SEDYELLVLQHACCPYC 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oseg1	NP_648221.3	WD40	<22..296	CDD:441893	154/331 (47%)
		WD40 repeat	25..59	CDD:293791	18/33 (55%)
		WD40 repeat	65..99	CDD:293791	21/33 (64%)
		WD40 repeat	104..136	CDD:293791	21/31 (68%)
		WD40 repeat	144..214	CDD:293791	41/127 (32%)
		WD40 repeat	233..267	CDD:293791	16/33 (48%)
		WD40 repeat	275..301	CDD:293791	9/25 (36%)
		LapB	654..910	CDD:442196	110/255 (43%)
Ift122	XP_006506860.1	WD40	<15..350	CDD:441893	155/335 (46%)
		WD40 repeat	15..51	CDD:293791	18/35 (51%)
		WD40 repeat	57..91	CDD:293791	21/33 (64%)
		WD40 repeat	96..128	CDD:293791	21/31 (68%)
		WD40 repeat	136..172	CDD:293791	26/35 (74%)
		WD40 repeat	283..317	CDD:293791	16/33 (48%)
		LapB	694..918	CDD:442196	100/223 (45%)